리네졸리드와 반코마이신을 교대로 투여하여 치료한 지속성 메티실린 내성 황색포도알균 균혈증 1예

김낙현,김문석,장은선,강유민,김가연,장희창,박완범,김의종,김남중,오명돈 대한감염학회 2009 감염과 화학요법 Vol.41 No.6

Persistent Staphylococcus aureus bacteremia is frequently defined as bacteremia persisting for ≥7 days despite proper antibiotic therapy. Its treatment includes removal of all infection foci and proper antibiotic therapy. Vancomycin remains the antibiotic of choice in MRSA bacteremia. Alternative agents, linezolid or daptomycin, are available, but a consensus regarding management of persistent MRSA bacteremia on vancomycin failure is still lacking. We report a case of a 60-year-old male who received thoracoabdominal aorta replacement operation due to dissecting aneurysm of the ascending and descending aorta. Surgical site infection and bacteremia caused by MRSA occured, and wound debridement operations were performed. The patient was treated with vancomycin in therapeutic doses but MRSA bacteremia persisted for 168 days in a row. Although the inserted aortic graft was the most probable source of persistent bacteremia, surgical removal was impossible. Linezolid was administered as an alternative antibiotic but had to be discontinued from time to time due to thrombocytopenia induced by this agent. In the end, MRSA bacteremia was successfully managed by alternating vancomycin-linezolid therapy.

Hydrogen-assisted stress corrosion cracking simulation using the stress-modified fracture strain model

김낙현,윤기봉,김윤재 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.8

This paper proposes a numerical method to simulate hydrogen-assisted stress corrosion cracking, via coupled diffusion elastic-plastic finite element damage analyses based on phenomenological stress-modified fracture strain model. For validation, simulated results using the proposed method are compared with published experimental data of FeE 690T compact tension tests under air and hydrogen condition with various constant load-line displacement rates. The simulated results agree well with experimental data.

소듐냉각고속로 잔열제거계통 강제대류 소듐-공기 열교환기의 구조개념 설계

김낙현,이사용,김성균,Kim, Nak Hyun,Lee, Sa Yong,Kim, Sung Kyun 한국압력기기공학회 2016 한국압력기기공학회 논문집 Vol.12 No.1

The FHX (Forced-draft sodium-to-air Heat Exchanger) employed in the ADHRS (active decay heat removal system) is a shell-and-tube type counter-current flow heat exchanger with M-shape finned-tube arrangement. Liquid sodium flows inside the heat transfer tubes and atmospheric air flows over the finned tubes. The unit is placed in the upper region of the reactor building and has function of dumping the system heat load into the final heat sink, i.e., the atmosphere. Heat is transmitted from the primary cold sodium pool into the ADHRS sodium loop via DHX (decay heat exchanger), and a direct heat exchange occurs between the tube-side sodium and the shell-side air through the FHX tube wall. This paper describes the DHRS and the structural design of the FHX.

리네졸리드와 반코마이신을 교대로 투여하여 치료한 지속성 메티실린 내성 황색포도알균 균혈증 1예

김낙현,김가연,장희창,김의종,오명돈,김남중,김문석,장은선,강유민,박완범 대한감염학회 2009 Infection and Chemotherapy Vol.41 No.6

Persistent Staphylococcus aureus bacteremia is frequently defined as bacteremia persisting for ≥7 days despite proper antibiotic therapy. Its treatment includes removal of all infection foci and proper antibiotic therapy. Vancomycin remains the antibiotic of choice in MRSA bacteremia. Alternative agents, linezolid or daptomycin, are available, but a consensus regarding management of persistent MRSA bacteremia on vancomycin failure is still lacking. We report a case of a 60-year-old male who received thoracoabdominal aorta replacement operation due to dissecting aneurysm of the ascending and descending aorta. Surgical site infection and bacteremia caused by MRSA occured, and wound debridement operations were performed. The patient was treated with vancomycin in therapeutic doses but MRSA bacteremia persisted for 168 days in a row. Although the inserted aortic graft was the most probable source of persistent bacteremia, surgical removal was impossible. Linezolid was administered as an alternative antibiotic but had to be discontinued from time to time due to thrombocytopenia induced by this agent. In the end, MRSA bacteremia was successfully managed by alternating vancomycin-linezolid therapy.

朴八陽論-작가의 現實認識 태도를 중심으로-

김낙현 한국어문교육연구회 2002 어문연구(語文硏究) Vol.30 No.2

A Study of Park Pal-yang's Poetry -Focusing on the poet's attitude toward perceiving reality- Kim, Nak-hyeon The purpose of this article is to study ‘Yeosu(麗水)’, Park Pal-yang's attitude toward perceiving reality. The stream of Park's attitude toward perceiving the reality is determined by the changing tendency of the times and circumstances. After his literary debut in 1923, Park, Pal-yang showed sentimental and ideal attitude toward perceiving reality. Later, he created pro-poems based on much more developed perception of reality than in the past. Afterwards, Park expressed the poetic consciousness of recurrence to nature and modernism based on reflective and post socialized perception of reality. Finally, after the 1945 Liberation, and during the period when he was active in North Korea, Park, Pal-yang showed attitude that complies with the socialism. Park passed away in 1988. This fact, however, has not been verified in existing discussions. Park, Pal-yang was the man of marked individuality and his poems possess various mental historical aspects. 본고는 시대와 환경의 변화 조류에 따라 그 흐름이 변화되었던 麗水 朴八陽의 현실인식의 태도를 구명하는데 목적을 두었다.朴八陽 詩에서 나타난 현실인식 태도의 推移를 보면, 1923년 문단데뷔 후, 感傷的이고 觀念的인 현실인식의 태도를 선보였으며, 카프 목적의식기 이후에는 前代보다 훨씬 진전된 현실인식을 바탕으로 한 프로詩를 창작하였다. 그후, 내성화되고 탈역사화된 현실인식의 태도를 바탕으로 자연으로의 回歸意識과 모더니즘적인 성향의 詩意識을 표출하기도 하였다. 해방이후 북한에서의 활동시기에는 철저하게 社會主義 體制에 副應하는 태도를 보여 주었다. 지금까지 기존 논의에서 밝혀지지 않은 사실로 박팔양이 1988년에 북한에서 사망한 사실을 본고에서 밝히며, 그의 詩的 特性을 단적으로 말하면, 다양한 精神史的 斷面을 두루 지닌 독특하고 개성적인 시인이었다고 평할 수 있다.

13년간 한 대학병원 혈액배양에서 분리된 균의 분포 및 항생제 감수성 변화 양상

김낙현,황정환,송경호,최평균,박완범,김의석,박상원,김홍빈,김남중,오명돈,김의종 대한감염학회 2012 Infection and Chemotherapy Vol.44 No.4

Background: Local epidemiologic data on prevalent pathogens are important to guide empirical antibiotic therapy. In this study, we observed annual changes in frequency of occurrence and in vitro antimicrobial susceptibility of blood isolates over a period of 13 years. Materials and Methods: We reviewed blood isolates identified during the period from 1998 to 2010 at Seoul National University Hospital. Only first isolates for each patient were included in the analysis. We analyzed the frequency of isolates and their trend with regard to in vitro antimicrobial susceptibility. Data were presented according to guidelines of the Clinical and Laboratory Standards Institute (CLSI) (2009). Results: A total of 23,501 isolates were identified during the period from 1998 to 2010. Fifty-five percent of the isolates were gram-positive cocci, 38% were gram-negative rods,and 3% were fungi. Coagulase-negative Staphylococcus (CoNS) (24%), Escherichia coli (16%), Staphylococcus aureus (10%), and Klebsiella pneumoniae (8%) were the most commonly isolated bacteria, and Candida albicans (2%) was the most commonly isolated fungus. The frequency of CoNS increased from 18.0% to 26.8%,whereas the frequency of E. coli and K. pneumoniae decreased from 20.2% to 13.7%and from 11.7% to 6.7%, respectively. Overall, the proportion of methicillin-resistant S. aureus changed from 47.9% to 62.1%. In E. coli, the resistance rate of cefotaxime and ciprofloxacin increased over a period of 13 years. However, such an increase of resistance was not observed in K. pneumoniae. In P. aeruginosa , and particularly in A. baumannii , resistance to imipenem rose alarmingly (3% in 1998 to 27.8% in 2010, 5% in 1998 to 68.9% in 2010, respectively). Conclusions: Over the last 13 years, the proportion of CoNS in blood isolates increased,which led to a relative decrease of isolated gram-negative rods. Proportions of MRSA showed no significant change, whereas cefotaxime resistant and ciprofloxacin resistant E. coli increased. Imipenem resistant P. aeruginosa and A. baumannii also increased during the study period.

친환경 건설정책의 변화에 따른 콘크리트 환경성적표지인증의 필요성 및 현황

김낙현,Kim, Rak-Hyun 한국건설순환자원학회 2019 한국건설순환자원학회지 Vol.14 No.3

유럽연합 무기계 건설폐기물 재활용 현황 및 연구 사례

김낙현,Kim, Rak-Hyun 한국건설순환자원학회 2020 한국건설순환자원학회지 Vol.15 No.1

산·관·학 협력과 지역 중소기업가의 마음

김낙현 전남대학교 기업경영연구소 2005 經營情報 Vol.16 No.2

趙基天論 -생애와 문학 활동에 대한 재검토-

김낙현 한국어문교육연구회 2010 어문연구(語文硏究) Vol.38 No.3

The objective of this dissertation is to fully clarify Cho Ki Cheon’s life and literary activity which were not defined so far notwithstanding his position in literature. As a Koryo poet in USSR, he entered North Korea immediately after emancipation to play the role of leader of literature in North Korea with new genre and contents in the initial stage of North Korean literature. Unlike what has been known in the past, Cho Ki Cheon was not from Hweryung, Hamkyungbukdo, but from Spassk(Спасск) Village in the Maritime Province of Siberia. He launched his first poem, 「Pariskkom Muna」 in 1930 (18 years old). Influenced by Cho Myung Hee, the pioneer of literature of Koryo, Cho Ki Cheon acquired the literary view of ethnic group and class strife for emancipation on the basis of socialistic ideology. He was a USSR poet who was dispatched to North Korea by USSR immediately after emancipation so as to transmit the system and literature of USSR. Creating 「Song of land」, 『Mt. Baekdu』, etc in the initial literary circle of North Korea, Cho Ki Cheon presented the direction to which the literature of North Korea should move. His life and literature of diaspora ended when he was 39. 이 논문의 목적은 문학적 위상에 비해 그동안 규명되지 않았던 趙基天의 생애와 문학 활동을 최대한 정밀하게 밝히는 데 있다. 그는 在蘇 고려인 시인으로서 해방 직후 入北하여 초기 북한문학의 형성기에 새로운 장르 개척과 내용으로 북한문학을 이끈 향도자적 역할을 하였다. 그가 첫 시를 발표한 시점은 1930년(18세)이고 그 작품은 「파리꼼무나」이다. 조기천은 고려인 문학의 선구자인 趙明熙의 영향 하에 社會主義 理念을 근간으로 하는 민족과 계급해방투쟁의 문학관을 지니게 되었다. 그는 해방 직후 소련에 의해 북한에 파견된 소련파 시인으로서 초기 북한문단에서 「땅의노래」, 『白頭山』 등을 창작하여 북한문학이 나아갈 방향을 제시하였다. 그의 디아스포라diaspora적인 삶과 문학은 39세를 일기로 마감하게 되었다.