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김낙인 ( Nack In Kim ) 한국피부장벽학회 2007 한국피부장벽학회지 Vol.9 No.1
Psoriasis is an inflammatory skin disease that commonly causes itching and scaling. Because of its chronic and recurring nature, psoriasis can affect a person`s quality of life. In this lecture, we will see the effects of psoriasis on skin, especially on skin dryness. The decision to employ a particular treatment is based on the type of psoriasis, its location, extent, severity, and the age and gender of the patients. There can be variations between individuals in the effectiveness of specific psoriasis treatments such as topical, systemic treatment and phototherapy. Among the topical treatments for psoriasis, the most important and basic consideration is use of a skin moisturizer. These products produce an occlusive film that limits evaporation of water from the skin and allows the stratum corneum to rehydrate itself. Hydration of the stratum corneum can also lead to enhanced delivery of other medications, such as corticosteroids. In psoriatic skin lesions, it is well established that the transepidermal water loss (TEWL) values increase and decrease when a moisturizer is applied, so these values have also been used to monitor the efficacy of active treatments for psoriasis. Because dryness in psoriasis is the principal cause for increased severity, using the proper moisturizer is necessary and beneficial for patients suffering with psoriasis.
가족성 양성 만성천포창의 - 전자현미경적 소견의 관찰 -
김낙인(Nack In Kim),이춘봉(Choon Bong Lee),이무형(Moo Hyung),허충림(Choong Rim Haw) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.5
A 25-year-old man with familial benign chronic pemphigus presented with a one-year history of a localized pruritic recurrent eruption on his perianal area, Physical examination showed moist, macerated, fissured and scaly patches on erythematous base, A biopsy specimen showed extensive intraepidermal separation containing acantholytic cells. Electron microscopic observation showed widened intercellular space, detachment of the tonofilaments from the desmosomes, and subsequent concentration of the tono filaments around the nucleus. Microvilli were elorigated, thinned and branehed. 1)esmosomes were reduced in number. This case is unique in its clinical location, showing no family tendency.
여드름 환자의 혈중 Testosterone 및 Dehydroepiandrosterone - sulfate 농도에 관한 연구
김낙인(Nack In Kim),오희수(Hee Soo Oh),이상수(Sang Soo Lee),이무형(Moo Hyung Lee),허충림(Choong Rim Haw) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.1
This study was performed to detect the hormonal abnormalities and to investigate the relationship between the levels of plasma testosterone and DHEA-S in 21 female patients with acne vulgaris using radioimmunoassay. The results were as follows : 1. The levels of plasma testosterone in patients group and control group(n=9) were 352+11.8 ng/dl, 223+ 9.7 ng/dl, respectively, and significantly elevated in patient group(p < 0.01), 2. The levels of plasma DHEA-S in patient group and control group were 286.6+ 126.8 pg/dl, 238.6+60.0 pg/dl, respectively, and did not show statistical significance. 3. The levels of plasma testosterones in patient subgroups classified by modified Pillsbury method were as follows minor group 32.6+5.3 ng/dl, mild group 33.4+15,5 ng/dl, moderate group 39.6+12.6 ng/dl. The testosterone levels in all the subgroups increased significantly than those in control group(352-t11.8 ng/dl) (p<0.05, p<0.05 p < 0.01) 4. The levels of plasrna DHEA-S in patient subgroups were follows minor group 242.5+412 pg/dl, mild group 263.9+166.1 pg/dl, moderate group 353.4+-1273 pg/dl. The DE3EA-S levels in moderate group increased significantly than those in cotrol (238,6+60,0 pg/dl) and minor group(p<0.05). 5. There was no correlation between the plasma testosterone levels and the plasma DHEA-S levels in the acne patients.