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RISS 인기검색어
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- 저자 : 김낙인 ( Hang Rae Cho (검색결과 4 건)
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건선의 초기 병변과 만성 병변에서의 침윤세포 성상에 관한 면역조직화학적 연구
조항래,심우영,양문호,김낙인 ( Hang Rae Cho,Woo Young Sim,Moon Ho Yang,Nack In Kim ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.1
Backgrou~nd: Psoriasis is a chronic relapsing disease characterized by epidermal hyperproliferation and epiderrnal and dermal inflammatory cell infiltrat,ion. The etiology of this disease is still unclear. Recently, there has been growing interest in the probable role of a T cell mediated immune response in the pathogetiesis of psoriasis. The infiltrating cells in psoriatic lesions have been iden- tified by monoclonal ant~ibodies and T cells were found to be the major infiltrating type. Objective : This stud was done to investigate the difference of cellular infiltration and adhesion molecule exg!ressions between early and late skin lesions of psoriasis using immunohistochernical studies. Methpds : Patients with psoriatic lesions were divided into two groups. The early gr oup were defined as having skin l~i:sions that had lasted for about 4 weeks, and late group were defined as having skin lesions that had lasted for more than 8 weeks. Then biopsy specirnens were stained using monoclonal antibidies for CD4, CD8, CD1, LFA-1, and ICAM l. Results : 1. CD4 positive cells,vere tly increased in both the early and late groups compared with CD8 positive cells. Z. CD8 positive cells were significantly increased in the late g~roup compared with the early group. 3. CDl-posit,ive dendri!ic cells were more nurnerous in the late group than the early group. 4. There were no significant differences between the early and late group with regard to numbers of LFA-1 positive (ells. 5. ICAM-1 were more strongly expressed on epidermal keratinocytes in the late than the early group. Conclusion : CD4-positive cells are important in early and late psoriatic lesions and CD8 positive cells playi more important role in late than early lesions. ICAM-1 and LI'A-1 play a role in cell adhesion of infiltrating cells and lymphocytic rnigration to the epidermis. (Kor J Dermatol 1997;3~5(1): 49-56)
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5 Cases of Solitary Mastocytoma
김낙인,조항려 대한피부과학회 1997 Annals of Dermatology Vol.9 No.2
We report five cases of solitary mastocytoma. All patients were under one year of age and diagnosed as solitary mastocytoma based on clinicopathologic findings. Skin lesions were found on the right forearm, left hand, left leg, left elbow and left shoulder. They resolved themselves spontaneously resolution within 2 or 3 years.
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김낙인,조항래,김형섭 대한의진균학회 1996 대한의진균학회지 Vol.1 No.1
Cutaneous ulcers due to candida infection are very rare condition, occurring almost in immunocompromised host or occuring as cutaneous manifestation of systemic candidal infection. A 52-year-old woman presented with cutaneous ulcer on dorsum of left hand which had lasted for about 15 days. Bacterial culture showed nonpathogenic organism, Enterobacter cloacae. Mycologic studies including KOH mount and fungus culture were positive for pseudohyphae and colonies of Candida species. A biopsy specimen from the center of ulcer revealed numerous spores and fungal hyphae in the upper dermis and necrotic epidermis. Bacterial culture and fungus culture of patient's serum and urine were negative. Initial treatment with antibiotics had no effectiveness for 2 weeks. After then we treated with antifungal drug, itraconazole 100mg/day. After 6 weeks of antifungal therapy, the skin lesion was much improved. We report this case, because it showed cutaneous ulcer due to candida infection but had neither systemic candidal infection nor clinical sign of immunosuppression.
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