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김국민 ( Kook Min Kim ),조용근 ( Yong Keun Cho ),황유정 ( Yu Jeong Whang ),오수진 ( Su Jin Oh ),홍윤경 ( Yun Kyung Hong ),나영균 ( Yong Gyun Na ),강선미 ( Seon Mi Kang ),김인희 ( In Hee Kim ),김상욱 ( Sang Wook Kim ),이수택 ( Soo 전북대학교 의과학연구소 2006 全北醫大論文集 Vol.30 No.1
소화성 궤양에서 천공은 심각한 합병증 중 하나로써 적절한 치료를 받지 않을 경우 사망할 수 있다. 이에 대한 치료 방법으로 현재까지 수술적 치료가 주된 방법이지만 선택된 천공 병변에서 비수술적 치료를 시행하여도 효과적이다. 저자들은 산부인과 수술 후 발생한 자발성 십이지장 궤양 천공환자에서 비수술적 요법으로 유지 후 효과적으로 치료된 예가 있어서 문헌고찰과 함께 보고한다. The ulcer perforation is a major complication of peptic ulcer disease. Surgical repair is the standard treatment of patients with perforated peptic ulcer. However, nonoperative management was indicated in patient without the clinical sign of peritoneal inflammation because perforated peptic ulcers are frequently sealed spontaneously by omentum or adjacent organ. We report a case of perforated duodenal ulcer in a 42-year-old woman who was successfully treated with nonoperative management.
The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis
김상두,Soonil Kwon,Sung Kyun Lee,국민수,이하영,Ki-Duk Song,Hak Kyo Lee,백석환,Chan Bae Park,배외식 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.9
In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases in body weight, bleeding score and stool score in addition to reversing DSS-induced mucosa destruction and shortened colon. The WKYMVm-induced therapeutic effect against ulcerative colitis was strongly inhibited by a formyl peptide receptor (FPR) 2 antagonist, WRWWWW,indicating the crucial role of FPR2 in this effect. Mechanistically, WKYMVm effectively decreases intestinal permeability by stimulating colon epithelial cell proliferation. WKYMVm also strongly decreases interleukin-23 and transforming growth factor-b production in the colon of DSS-treated mice. We suggest that the potent immune-modulating peptide WKYMVm and its receptor FPR2 may be useful in the development of efficient therapeutic agents against chronic intestinal inflammatory diseases.
프리텐셔너가 장착된 시트벨트 시스템의 관성잠김 안전버클 개발
국민구(Min-Gu Kuk),탁태오(Tea-Oh Tak),박재순(Jae-soon Park),신승언(Seung-Eon Shin),김대희(Dae-Hee Kim),김종각(Jong-Kag Kim),유병개(Byoung-Gae You),김철현(Chul-Hyun Kim) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.6
To improve passenger safety, seatbelt systems with pre-tensioner that tightens seatbelt webbing using explosive just before collision are widely used these days. Even though seatbelt must not unlatched without passenger's operation, explosive power of pre-tensioner can cause unlocking of a buckle. To prevent the unlocking, an Anti-g mass that blocks displacement of the release button has been attached to the buckle. In this study, the dynamics and statics of locking mechanism associated with operation of Anti-g buckle has been theoretically investigated, and important design variables that affect the operation of Anti-g buckle have been identified. Through the total seatbelt system's dynamic simulation using force and displacement inputs obtained from seatbelt sled test, design of the proposed Anti-g buckle has been validated.
소관동맥 질환에서 재협착 감소를 위한약물용출 스텐트의 효과
황유정,김현숙,김국민,채제건,이경석,김원호,고재기 대한심장학회 2006 Korean Circulation Journal Vol.36 No.6
Background and Objectives:The previous studies have demonstrated the superiority of implanting drugeluting stent (DES) for restenosis reduction compared with the implantation of uncoated stents in smallcoronary arteries. However, the arteries in those studies tended to have short lesions. So, we evaluated theefficacy of a drug eluting stent in small coronary lesions with a relatively long length. Subjects and Methods:From July 2003 to March 2005, DESs (Cypher or Taxus) were implanted into 100 consecutive patients with 116lesions that were less than 2.75 mm in diameter. All patients received aspirin indefinitely and clopidogrel for 6months. The primary end point was 6 month angiographic in-segment restenosis, and the secondary end pointswere procedural success and any major adverse cardiac events (MACE: death, non fatal myocardial infarctionand target lesion revascularization) at 9 months. Results:The mean age of the patients was 63 years, 53% weremale, 24% were diabetics, 34% were current smokers and 55% had hypertension. A total of 121 DESs wereimplanted into 116 lesions (mean number of DESs/lesion: 1.1/lesion). The mean proximal and distal referencediameters were 2.21±0.39 and 2.01±0.40 mm, respectively. The mean lesion length was 19.14±7.89 mm. Themean pre- and post- minimal lumen diameters were 0.73±0.42 mm and 2.26±0.41 mm, respectively. Themean size and length of the stents were 2.65±0.13 mm and 28.46±10.04 mm, respectively. The proceduralsuccess rate was 98.3%. The angiographic follow-up rate was 78.4%. The binary in-segment restenosis rate was15.4% (14 lesions). The MACE at 9 months was 8.0%. Conclusion:DES implantation in small coronarylesions with a relatively long length demonstrated favorable results. However, a larger scale study is needed toclarify the efficacy of the DES in small coronary arteries. (Korean Circulation J 2006;36:450-457) 배경 및 목적:이전의 대부분의 연구들에서 소관동맥 질환에 약물용출스텐트를 삽입하였을 경우 나스텐트를 삽입한 경우보다 재협착율이 낮음을 보여 주고 있으나 이들은 대부분 병변 길이가 짧은 경향이 있어 긴 병변을 가진 소관동맥 질환에서도약물용출 스텐트가 효과적인가에 관해서는 확실하지가 않다. 따라서 본 연구에서는 소관동맥 질환에서 긴 병변을 가진 환자군을 포함하여 약물용출 스텐트의 효과에 대해 알아보고자 하였다.방 법:2003년 7월부터 2005년 3월까지, 2.75 mm 이하의 직경을 가진 소관동맥 질환을 가진 100명의 환자, 116 병변에CypherTM, TaxusTM를 임의로 선택하여 삽입하였다. 일차연구 종료 시점은 6개월 후 추적 관동맥 조영술 검사 결과Yu-Jeong Whang, et al:Drug Eluting Stents in Small Coronary Arteries·457분절 내 재협착으로 하였고 이차 연구 종료 시점은 시술 성공과 9개월 후 주요 심장사건으로 하였다. 결 과: 평균 연령은 63세, 53%가 남자였고, 평균 연령은 63±10 (범위: 39~82)세로 남자가 53%이었고, 고혈압 56%, 고지혈 증 31%, 흡연 34%, 당뇨 24%, 전에 재관류 시술을 받은 과 거력은 14%이었다. 총 121개의 약물용출 스텐트가 116개의 병변에 삽입되었다. 평균 근위부, 원위부 참조 혈관 내경은 2.21±0.39 mm, 2.01±0.40 mm이었고 평균 병변 길이는 19.14±7.89 mm이었다. 평균 시술 전, 후 최소 내경은 0.73± 0.42 mm, 2.26±0.41 mm이었다. 평균 삽입된 스텐트 크기 및 길이는 2.65±0.13 mm, 28.46±10.04 mm이었다. 시술 성공률은 98.3%이었다. 추적 관동맥 시술률은 78.4%이었다. 6개월 후 분절 내 재협착율은 15.4%(14예)이었으며(TaxusTM 17.2%, CypherTM 14.5%), 9개월 후 주요 심장사건은 8.0% 이었다(TaxusTM 11.6%, CypherTM 4.1%). 결 론: 비교적 긴 병변을 대상으로 한 본 연구를 통해 소관동맥 질 환에서 약물용출 스텐트는 재협착율, 주요 심장 사건면에서 효과적임을 알 수 있으나 좀 더 대단위의 장기간의 연구가 필요하겠다.