대퇴사두근 집중훈련이 노인의 슬관절 기능 향상에 미치는 영향

김계엽,김미현,김효동,김효진,박선영,손수옥,유용인,이소라,정다혼,조은지,황지윤,심기철,김경윤 대한스포츠물리치료학회 2010 정형스포츠물리치료학회지 Vol.6 No.1

The purpose of this study was to compare the effect of balance ability in elderly women by the knee joint training. Thirty two elderly women aged 65 to 80 had been participated in this study. AII the patient were treated 3 times session weekly for 5 weeks. The participants were divided randomly as group 1 (n = 8) , group 11 (n = 8), group 111 (n = 8), and group IV(n = 8). In group of participants were non treatment. In group 11 of participants were exercised only QSE(Quadriceps Setting Exercise). In group 111 of participants were exercised using Thera band. In group IV of participants were exercised both QSE and using Thera band. For 5 weeks , three(group 11 , 111 , IV) exercise group took the training an hour in each 3days of a week and we raised the intensity of exercise of three groups following two weeks from the start. We compared the group 1 with the other groups. The results obtained are as followings First, Experimental group 11 , 111 , IV were showed significant difference, especially experimental group IV was only showed greatest significant difference in comparision with group 1 in change of quadriceps strength , pressure pain threshold , one leg stance test, timed up and go test, WOMAC according to 5 weeks(P< .001). In conclusion this study showed that group IV compared to group I had significantly change than group 11 and group 111 compared to group 1 in all test. Therefore, this study revealed that quadriceps intensive training has the affirmative ifluence on function of knee joint in elderly adults.

관절염 모델에서 침형 경피신경 자극의 효과

김계엽,김태열,김경윤 東新大學校 2003 論文集 Vol.13 No.-

The purpose of this study was to investigate and analyze effect of needle transcutaneous electrical nerve stimulation with the change of immunohistochemistry method through the change of c-fos in spinal dorsal horn(pre, 4, 8, 12 and 24h). An experimental arthritis induced in 100 Sprauge-Dawley rats with a mixture 3% carrageenan and 3% kaolin(0.1 ㎖ in sterile saline) into the joint cavity of one knee. Each group was randomly divided into four groups; Group Ⅰ : control group, Group Ⅱ : arthritic limb-induced group, Group Ⅲ : Needle TENS application on ipsilateral arthritic limb(2 Hz, 200 μs, 20 min) group, Group IV : Needle TENS application on contralateral arthritic limb(2 Hz, 200 μs, 20 min) group. The results of this study were as follows: 1. In naked eyes opinion, c-fos immunoreactive positive neurons are increased markedly 4 hours after arthritis limb-induced in Rexed Ⅰ, Ⅱ of superficial dorsal horn. Group Ⅲ and group Ⅳ are more decreased than Group Ⅱ at 8 hours after arthritis limb-induced. 2. The c-fos immunoreactive positive neurons after application needle like transcutaneous electrical nerve stimulation on arthritic limb-induced model group are more decreased than only arthritic limb-induced group. 3. The number of c-fos immunoreactive positive neurons in superficial dorsal horn was decreased markedly 4 hours after arthritis limb-induced. Group Ⅲ and group N are more decreased than Group Ⅱ at 8 hours after arthritis limb-induced(p<0.001). Specially Group Ⅲ showed the most significantly effect at 8 hours(p<0.01). The above results suggest that needle transcutaneous electrical nerve stimulation effectively reduced in arthritic limb-induced model. In addition, greatly decreased the number of c-fos neurons explains needle transcutaneous electrical nerve stimulation application on ipsilateral arthritic limb is more effective than that on contralateral arthritic limb.

육용계 병아리에서 발생한 리보플라빈 결핍증

김계엽,Kim, Gye-Yeop 대한수의학회 2001 大韓獸醫學會誌 Vol.41 No.4

The chicks from 6 field broiler farms revealed peripheral neuropathy including leg weakness, curled toes and drooped wings. Grossly distinctive enlargements of sciatic nerve, branchial nerve and lumbar nerve were observed in the chicks. Histologically nerve lesions consisted of demyelination of myelin sheaths, Schwann cell proliferation and swelling, and interstitial edema in the peripheral nerves of all birds examined. Axonal swelling and infiltration of small lymphocytes were observed, but not a primary lesion. After treatment of riboflavin, neurological disorder was markedly recovered. From these results, it is suggested that the peripheral nerve lesions in these cases were caused by dietary riboflavin deficiency.

면역억압계군에서 Salmonella gallinarum 감염에 대한 면역반응

김계엽,임재향,고홍범,조경오,김태열,오명화,Kim, Gye-Yeup,Lim, Jae-Hyang,Koh, Hong-Bum,Cho, Kyoung-Oh,Kim, Tae-Youl,Oh, Myoung-Hwa 대한수의학회 2002 大韓獸醫學會誌 Vol.42 No.3

The immune response against Salmonella gallinarum infection was investigated in immunosuppresed chickens. Newly hatched chickens were treated with cyclophosphamide at the first and second day after birth and were challenged intraperitoneally with S gallinarum ($1{\times}10^7CFU/m{\ell}$) on day 6. Group 1, Immunosuppresed and Challenged group, was treated with cyclophaiphamide and challenged with S gallinarum; group 2, Immunosuppressed group, was only treated with cyclophsphamide; group 3, Challenged group, was only challenged with S gallinarum; group 4, Control group. In each group, the localization of lymphocytes of the lymphoid organs and intestine was immunohistochemically compared using a variety of monoclonal antiboies ($CD4^+$, $CD8^+$, and B lymphocyte). Also, S gallinarum were assessed by Maccallum-Goodpasture stain and immunohistochemical analysis in the paraffin-embedded intestinal tissues. In S gallinarum challenged chickens, $CD4^+$ and $CD8^+$ lymphocytes of the intestinal organs such as duodenum, jejunum, ileum and colon were increased. However, in cyclophophamide treated chickens, $CD4^+$ and $CD8^+$ lymphocytes and especially B lymphocytes of the lymphoid organs such as thymus, spleen, and bursa of Fabricius were dramatically decreased. These results suggest that cyclophsophamide is an immunosuppressive agent that especially causes depletion of B lymphocytes, suppress humoral immunity and eventually suppresses avian immune responses. Its protection against S gallinarum infection is mainly dependent on both cell-mediated mechanism and the humoral immune response.

방사선 조사 마우스에서 오가피의 면역활성 효과

김계엽,정현우,김경윤,Kim, Gye-Yeop,Jeong, Hyun-Woo,Kim, Kyung-Yoon 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.6

This experimental study was carried out to investigate the immunostimulating effect of Acanthopanax, as Oriental rhizomata herbs, on jejunal survival, endogenous spleen colony formation, apoptosis in jejunal crypt cells and lipid peroxidation in the liver of mice following Gamma-ray irradiation. The subject of this study includes 72 mice which were divided into each 7 groups. Acanthopanax experiment groups were Acanthopanax. Gamma-ray(lOGy), Acanthopanax. Gamma-ray(3Gy), Acanthopnax. Gamma-ray(1Gy), Gamma-ray control(1OGy), Gamma-ray control(3Gy), Gamma-ray control(1Gy), Normal groups. The results of this study were as follows : Treatment with Acanthopanax showed significantly increased(p<0.05) on the cell death apoptosis in crypt, intestine crypts survival of intestine in mice following low-dose(1Gy) Gamma-ray radiation. And that significantly increased(p<0.05) on jejunal crypt survival and reduced(p<0.05) on lipid peroxidation in mice following high-dose(1OGy) Gamma-ray radiation. The above results suggest that Acathopanax were immunostimulating effectively reduced Gamma-ray irradiation.

보건계열 해부학 교육 과정

김계엽 대한체질인류학회 2014 대한체질인류학회 학술대회 연제 초록 Vol.57 No.-

국내에서 분리된 돼지 유행성 설사증 바이러스 접종자돈의 병리학적 소견

김계엽,박남용,정치영,박영석,Kim, Gye-Yeop,Park, Nam-Yong,Chung, Chi-Young,Park, Young-Seok 한국수의병리학회 1998 한국수의병리학회지 Vol.2 No.2

Twelve colostrum-deprived piglets were inoculated oral1y with porcine epidemic diarrhea virus isolated from Korea. The piglets were euthanatized from at 12 hour postinoculation(PI) at 6-hour intervals. At 24 to 36 hours PI, all infected piglets showed severe yellowish to watery diarrhea, dehydration, depression, and anorexia. At necropsy, the intestinal wall looked thin, mesenteric vessels congested, and mesenteric lymph nodes edematous. The histological findings showed marked villous atrophy and fusion, severe degeneration of enterocytes and monomuclear cell infiltration in the lamina propria. On electron microscopy, villous epithelial cells of infected jejunum contained viral particles at 18 hour PI. The viral particles were pleomorphic spheres with a mean diameter of 95∼180nm including 18nm projections.

미세전류자극 치료법의 진통효과

김계엽,오명화,김선은 東新大學校 2003 論文集 Vol.13 No.-

The purpose of study is that we will observe the change of CGRP(calcitonin gene-related peptide) within the cell with the immunohistochemistry method and then we will study the effect of microcurrent stimulation therapy following the frequency after inducing pain to rats with capsaicin. Eighty rat were classified to SD and they have growed for 8 weeks. I classify to four groups, ordinal group is used in experiment Ⅰ, the group which we induce pain is used in experiment Ⅱ, the application group which we induce pain and then the high frequency micro current stimulation is used in experiment Ⅲ, the application group which we induce pain and then the low frequency micro current stimulation is used in experiment Ⅳ, I get the following result. Compare with experiment Ⅱ, experiment Ⅲ, and expriment Ⅳ react from CGRP immunoreactive weakly, seven days later, they decrease remarkably. According to these results, from rats induced pain, micro current stimulation effect to reducing pain, but following frequency micro current stimulation therapy isn't different from immunoreactive CGRP.

고지혈증 동물모델에서 표고버섯(Lentinus edodes) 추출물이 항고지혈증에 미치는 영향

김계엽,정동조,김은정 한국약용작물학회 2013 한국약용작물학술대회 발표집 Vol.2013 No.05

트레드밀 운동과 저체온 적용이 척수손상 백서의 신경성인자 발현에 미치는 영향

김계엽,천진성,김기도,김은정,남기원,김경윤 한국스포츠리서치 2007 한국 스포츠 리서치 Vol.18 No.5