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Polymethacrylic Acid 하이드로겔 매트릭스로부터의 pH 의존성 약물 방출
김경충,김길수,이승진,Kim, Kyung-Chung,Kim, Kil-Soo,Lee, Seung-Jin 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.4
Drug release experiments were performed based on pH-sensitive swelling behaviors of polymethacrylic acid. 5-Fluorouracil as a nonionic model drug revealed release patterns depending solely on pH-dependent swelling kinetics of polymethacrylic acid. In contrast, release of propranolol hydrochloride as a cationic model drug was significantly affected by ionic drug-polymer interaction as well as the swelling kinetics. Accordingly, a zero-order release pattern was obtained at pH 7, which was distinguished from the general matrix type drug release pattern.
pH 의존성 Methacrylic acid 공중합체의 팽윤특성
김경충(Kyung Chung Kim),이승진(Seung Jin Lee) 대한약학회 1989 약학회지 Vol.33 No.6
Equilibrium swelling and pH-sensitivity of a polyelectrolyte copolymer hydrogel were controlled by employing copolymers with different hydrophilic-hydrophobic balances. Model pH-sensitive hydrogels, e.g., poly(methacrylic acid), poly(methacrylic acid-co-acrylamide), poly(methacrylic acid-co-2-hydroxyethylmethacrylate), poly(methacrylic acid-co-styrene) were synthesized at various monomer compositions. As hydrophobicity of the copolymer hydrogels increased, the equilibrium swelling decreased while the pH-sensitivity increased. In the case of poly(methacrylic acid-co-acrylamide), polymer-polymer interaction significantly affected the equilibrium swelling and provided a wide range control of pH-sensitivity.
Polymethacrylic Acid 하이드로겔 매트릭스로부터의 pH 의존성 약물 방출
김길수,이승진,김경충 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.4
Drug release experiments were performed based on pH-sensitive swelling behaviors of polymethacrylic acid. 5-Fluorouracil as a nonionic model drug revealed release patterns depending solely on pH-dependent swelling kinetics of polymethacrylic acid. In contrast, release of propranolol hydrochloride as a cationic model drug was significantly affected by ionic drug-polymer interaction as well as the swelling kinetics. Accordingly, a zero-order release pattern was obtained at pH 7, which was distinguished from the general matrix type drug release pattern.
서은경,권은경,김영희,김진,김경충,김정수,김혜진,이진희 梨花女子大學校 藥學硏究所 1987 梨花藥學硏究 Vol.- No.26
In order to study the problems of air pdlution whose reduction can be achieved by adequate pollution control, and an objective appreciation of the problems and consequences by government industry, and the consumer, we have some tests for the air of subway. Experiments contained the measuring of the number of colony of Bacteria, the quantity of CO_2, pH, dust, air temperature, air moisture and kata cooling power. From this kata cooling power we calculated the air movement, and from the chart, we obtained the effective temperature. According to the results, the air of subway was polluted by dust, and most of the sampling points were within the comfort zone or comfort line.
서은경,권은경,김영희,김진,김경충,김정수,김혜진,이진희 이화여자대학교 약학회 1987 梨花藥學會誌 Vol.- No.26
In order to study the problems of air pdlution whose reduction can be achieved by adequate pollution control, and an objective appreciation of the problems and consequences by government industry, and the consumer, we have some tests for the air of subway. Experiments contained the measuring of the number of colony of Bacteria, the quantity of CO_2, pH, dust, air temperature, air moisture and kata cooling power. From this kata cooling power we calculated the air movement, and from the chart, we obtained the effective temperature. According to the results, the air of subway was polluted by dust, and most of the sampling points were within the comfort zone or comfort line.