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RISS 인기검색어
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- 저자 : 금창헌 ( Chang Hun Kum ) (검색결과 4 건)
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약물 방출 스텐트의 약물 방출 및 기계적 특성에 Ethylene Vinyl Alcohol와 Cellulose Acetate Butyrate가 미치는 영향
장부남 ( Bunam Jang ),강성남 ( Sung Nam Kang ),금창헌 ( Chang Hun Kum ) 한국키틴키토산학회 2017 한국키틴키토산학회지 Vol.22 No.1
Although drug-eluting stents have reduced the problem of restenosis, such stents exhibit side effects such as inhibition of re-endothelialization and inflammatory reactions due to persistent drug reactions and sensitivity of polymers. To solve this problem, suppressing the continuous drug reaction by controlling drug release behavior induce rapid vascular re-endothelization. In this study, we attempted to control drug release from a paclitaxel- and cilostazol-containing stent using ethylene vinyl alcohol (EVOH). We then used a scanning electron microscope and atomic force microscope to observe changes on the surface of the drug-releasing stent following the inclusion of EVOH in comparison with stent without EVOH. There were almost no differences on the surface of the drug-eluting stent due to EVOH. The drug release was initially higher in the EVOH-containing stent compared to the stent without EVOH, and the degradation behavior of the polymer not affected by addition of EVOH. Cytotoxicity of the stent containing EVOH was evaluated. EVOH did not exhibit any cytotoxicity due to the degree of controlled release of the drug. Additionally, mechanical property of stent was confirmed by using EVOH and cellulose acetate butyrate (CAB). Radial force increased in stent with EVOH compared to without EVOH although flexibility was not changed. These results suggest that the application of EVOH to drug-eluting stents does not affect the degradation behavior of the stent surface and polymer, but it could be expected to suppress the sustained and excessive response of the drug by rapid release of the drug.
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계면중합에 의한 폴리우레아 마이크로캡슐의 제조 -분산상의 점도에 따른 마이크로캡슐의 크기 변화-
이동선,금창헌,조창기,Lee, Dong-Sun,Kum, Chang-Hun,Cho, Chang-Gi 한국섬유공학회 2007 한국섬유공학회지 Vol.44 No.5
Polyurea microcapsules were prepared by interfacial polycondensation using diisocyanates as the oil soluble monomers and diethylenetriamine as the water soluble monomer. NP-10, nonionic surfactant, was used as an emulsifier. Toluene was used as the diluent of the diisocyanates as well as the means to prepare microcapsule with empty shell. Number average particle size of the microcapsule showed a linear relationship with the viscosity of the dispersed oil phase. Polyurea microcapsule with thinner shell thickness showed good thermal stability well above $250^{\circ}C$ and showed same thermal stability compared to that with thicker shell thickness.
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3가 크롬 흡착 증진용 과불소 알킬유도체 제조 및 적용공정 개발
신종섭(Jong-Sub Shin),금창헌(Chang Hun Kum),윤종국(Jong-Kuk Yun),박일규(Il-Kyu Park) 한국청정기술학회 2008 청정기술 Vol.14 No.3
피혁 제조 공정에서 계면활성제는 세정목적, 분산성 그리고 고착성 등을 부여하기 위해 사용되고 있다. 그러나 기존의 피혁 공정에서 사용되고 있는 계면활성제는 친수성기가 다량 포함되어 있어 향후 피혁 시장에서 요구될 것으로 기대되는 내오염성, 내수성, 내구성 등의 고기능성 특성을 재현하는데 문제점이 있다. 본 연구에서는 기존의 탄화수소 계열의 계면활성제의 문제점을 보완하기 위해서, 탄소-불소의 강한 결합에너지로 인한 표면장력 감소, 분산력 증대, 세정효과, 크롬 흡착력 증대 등의 특성을 나타내는 불소계 계면활성제를 제조하였다. 불소계 계면활성제의 사용으로 피혁 제조 공정의 분산성 증대, 침투력 상승 및 결합력을 향상시켜 크롬 흡착률 증가, 탄닝 폐수 배액의 크롬 함량 감소, 생물학적 산소 요구량, 화학적 산소 요구량의 함량 감소 및 물리적 특성이 향상되는 것을 확인하였다. A surfactant is used to assist the effect of cleaning, dispersibility and adhesion during leather manufacturing process. Existing surfactant for that process includes many hydrophilic groups that may cause problem such as stain, bad water resistance and poor durability, etc. It is potential problem to make high-performance property for future leather market. In this study, we have synthesized the fluorinated surfactant of which property decreases surface tension, increases dispersion, cleaning effect and the better chrome absorption by the high bond energy of C-F to complement weakness that the present alkyl derivative surfactants have. Using fluorinated surfactant, we can confirm that dispersion is increased, chrome absorption ratio is augmented with high osmosis and coherence, chrome content in the tanning waste water is reduced, BOD and COD contents are diminished and physical characteristics are improved.
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Cellulose Acetate Butyrate의 작용기 비율에 따른 스텐트의 약물방출거동 및 물리화학적 특성과 그에 따른 세포 독성의 변화 관찰
장부남 ( Bunam Jang ),강성남 ( Sung Nam Kang ),금창헌 ( Chang Hun Kum ) 한국키틴키토산학회 2018 한국키틴키토산학회지 Vol.23 No.1
CAB 작용기 비율에 따라 스텐트의 약물 방출 거동 및 세포 독성 등의 차이를 관찰해 본 결과 표면적, 기계적 특성에서는 유사한 결과를 나타내었지만, 약물 방출 거동, 세포 독성 등과 같은 결과에서는 유의한 의미를 갖는 결과 값이 도출될 수 있었다. 특히 약물 방출 거동에서 CAB_B를 사용한 스텐트에 비해 CAB_A 사용 스텐트가 전반적으로 방출률이 저하되었고, 그에 따른 세포 독성이 저하되어 세포의 생존율이 증가됨을 관찰할 수 있었다. 본 연구를 통해 약물 방출 스텐트 필수 조건인 약물 방출 조절을 위한 CAB 고분자의 기능성을 살펴보았고, 그에 따른 세포 독성 실험을 통해 생체 적합성을 갖춘 고분자로서의 활용성과 스텐트 내 재협착 등의 부작용을 효과적으로 치료할 수 있는 잠재성 등을 평가할 수 있었다. Although drug eluting stent effectively reduce restenosis compared to bare metal stent, it still has the side effect of the drug, which are continuously caused after the interventional procedure of the coronary artery stent, such as delayed re-endothelialization and thrombosis induced by hypersensitivity of drug and inflammation. In order to solve this problem, a controlled drug release profile was able to induce re-endothelialization of vessel sufficiently by minimizing the side effect of drug. In this study, we investigated drug release behavior, physico-chemical characteristics and cytotoxicity of the stent prepared according to the ratio of butyrate functional group of cellulose acetate butyrate (CAB) in order to demonstrate the possibility of minimizing side effect of drug. CAB exhibits hydrophobic properties as the ratio of butyrate functional groups increases. The drug release rate of high butyrate group decreased about 1.5-3.8 times compared with low butyrate group in case of hydrophobic drug such as paclitaxel. The cytotoxicity was confirmed by the MTT assay. The cell viability in high butyrate group increased about 29% compared to low butyrate group. These results indicate drug release profile was able to controlled by the ratio of the butyrate functional group in CAB. In addition, it suggests that it can be used as a factor to minimize secondary adverse effects such as delayed reendothelialization and thrombosis through inhibition of hypersensitivity and toxicity induced by drug continuously.
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