백서의 척수허혈시 허혈시간에 따른 신경손상과 유전자발현의 변화에 관한 연구

권재영,박상인,류지흠 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.38 No.5

Background: Spinal cord ischemia initiates a deleterious cascade of biochemical events that ultimately result in an increased intracellular calcium concentration. Many papers have been published on this topic but without a clear consensus on the best way of minimizing the problem. For the further study of preventing neurological injury after spinal ischemia, the proper animal model is necessary. In this study we compared spinal ischemia time on neurologic and histopathologic outcome, and inflammatory gene expression in transient spinal ischemia. Methods : Rats were anesthetized with halothane, and divided into 4 groups: 12.5 minutes of spinal ischemia (Group 1), 15 minutes of spinal ischemia (Group 2), 17.5 minutes of spinal ischemia (Group 3), and 20 minutes of spinal ischemia (Group 4). Spinal ischemia was produced by both induced hypotension and thoracic aortic cross clamping. After spinal ischemia neurologic scores were assessed after 1, 3, 6, and 24 hours. After 24 hours, rats were euthanized and spinal cords were removed for histopathologic assessment and an assay of TNF- a and IL-1 mRNA. Results : The neurologic scores worsened according to the ischemia time. The histopathologic scores correlated well with the neurologic scores. The TNF- a and IL-1 mRNA expression results of group 2 were larger than those of group 1. There were no significant differences between group 2, group 3, and group 4. Conclusions: Inflammatory gene expressions are increased during transient spinal ischemia. After 15 minutes of ischemia, no further increase of mRNA expression was shown. The 15 minutes of spinal ischemia was sufficient for the spinal ischemic study in rats. (Korean J Anesthesiol 2000; 38: 904~ 909)

온도 및 기계적 자극에 대한 진통제의 심맥관계 반응 억제효과 비교

권재영,백승완,김해규,정규섭,김인세,원영섭 대한마취과학회 1994 Korean Journal of Anesthesiology Vol.27 No.7

One of the important functions of nervous system is to supply the information related to the injury. Therefore, for various kinds of injuries, to feel pain is thought to be the part of this important function. There are A-fiber (Type I AMHs, Type II AMHs) & C-fiber (CMHs) which respond to the mechanical & thermal stimuli as the nerve fibers of peripheral unit performing this function. The phenomena expressed to us by these stimuli are those reaction like the in- crease of heart rate and the elevation of blood pvessure by stimulation of the autonomic nervous system as well as pain. As it is, using these reactions which are the most popular parameter of pain expression during anesthesia, we make the depth of anesthesia deeper or use analgesics as adjuvants. In general, there are many kinds of analgesics for adjuvants of anesthesia or for elimination of postoperative pain. To compare the efficiency of those analgesics toward pain, the authors studied the inhibitory effects of analgesics on the increase of pulse rate and mean arterial pressure evoked by the thermal and mechanical stimulations in rats. We used the agents popularly used in nowadays 1) Tramadol HC1, known as a potent analgesics, 2) Nalbuphine, antagonist of opioids, 3) Meperidine and Morphine, opioids to com- pare the efficiency of hemodynamic augumentation by the thermal and mechanical stimulations with the control group. The results were as follows; 1) The inhibitory effects on the increase in pulse rate and mean arterial pressure evoked by the stimulations were in the decsing order of morphine, meperidine, nalbuphine, and tramadol. 2) The inhibitory effect of morphine on the incmnent of pulse rate and mean arterial pressme was evident. 3) Meperidine and nalbuphine, not so much potent as morphine in inhibitory also inhibit to a considerable degree. 4) In the case of tramadol, the increament of pulse rate evoked by the stimulations were inhibited to some extent, but it was proven not to inhibit the elevation of mean arterial pressure.

흉강경하 교감신경 절제술시 흡입마취와 TIVA의 비교

권재영 부산대학교 병원 암연구소 2001 부산대병원학술지 Vol.- No.10

소아에서 수술 후 통증완화를 위한 미추차단시 국소마취제에 첨가한 epinephrine과 morphine의 효과

권재영 부산대학교 병원 암연구소 2006 부산대병원학술지 Vol.- No.20

Purpose: Caudal block has been used to treat postoperative pain after low abdominal surgery in pediatric patients. The purpose of this study was to evaluate the analgesic effects and incidence of side effects of caudal block with high and low dose of morphine or epinephrine in pediatric inguinal and low abdominal surgery patients. Subject and methods: Sixty patients, aged 1-5 years, were divided into three groups after anesthesia. Caudal block was performed with 0.2% ropivacaine 0.7 ml/kg with morphine 0.01 mg/kg (group M-10), 0.03 mg/kg morphine (group M-30), or 1:200,000 epinephrine (group E) before incision. Postoperative analgesic quality and side effects were assessed. Results: Pain/discomfort scores in the group M-l0 and M-30 were significantly lower than those of group E until 2 hours after recovery. Sedation scores in the group M-l0 and M-30 were significantly lower than those of group E just after recovery. The incidences of vomiting in group E and M-l0 were lesser than M-30 group. There were no significantly differences in parent satisfaction scores among groups. Conclusions: The addition of 0.01 mg/kg morphine to ropivacaine for caudal block provides effective postoperative analgesia with minimal side effects.

복합공정의 최적 운용을 위한 디지털트윈 기반 메타팩토리 설계 및 구현

권재영,이원희 대한산업공학회 2022 대한산업공학회 춘계학술대회논문집 Vol.2022 No.6

꾸지뽕나무의 생리활성 성분

권재영,황방연,이동호 고려대학교 생명자원연구소 2010 생명자원연구 Vol.18 No.-

국내 배달음식 이용건수 분석 및 예측

권재영,김시내,박은지,송종우,Kwon, Jaeyoung,Kim, Sinae,Park, Eungee,Song, Jongwoo 한국통계학회 2015 응용통계연구 Vol.28 No.5

우리나라는 세계적으로 배달음식 문화가 가장 많이 발달한 나라 중에 하나로 최근에는 일인가구의 증가와 배달앱 시장의 발달과 함께 그 성장 속도 또한 눈부시게 증가하고 있다. 따라서 배달음식 이용에 큰 영향을 미칠 것으로 예상되는 날씨와 날짜별 변수를 고려하여 시간대별 배달음식 이용건수를 예측함으로써 소비자와 생산자 모두에게 이익을 주는 예측모형을 찾고자 한다. 본 연구의 목적은 다양한 데이터마이닝 기법을 이용하여 2014년도 배달음식 통화건수를 예측하는데 있다. 예측에 사용되는 회귀 모형은 선형회귀모형, 랜덤 포레스트, 그래디언트 부스팅, 서포트 벡터 기계, 신경망, 로지스틱 회귀모형으로 총 6가지이다. 고려되는 배달음식 업종은 총 4가지(족발/보쌈정식, 중국음식, 치킨, 피자)로 크게 두 가지 방법을 이용하여 각 업종별 배달음식 이용건수를 예측하였다. 첫 번째 방법은 총 이용건수와 각 업종별 배달음식 이용비율을 곱하여 각 업종별 배달음식 이용건수를 예측하는 것이고, 두 번째 방법은 각 업종별 모형을 세워 각 업종별 배달음식 이용건수를 예측하는 방법이다. 최종적으로 선택된 모형은 방법 1에서는 신경망 모형과 선형회귀모형이며, 방법 2에서는 신경망 모형이었다. 방법 2보다는 방법 1로 구한 결과가 더 예측력이 좋은 것으로 나타났다. Food delivery services are well developed in the Republic of Korea, The increase of one person households and the success of app applications influence delivery services these days. We consider a prediction model for the food delivery service based on weather and dates to predict the number of food delivery services in 2014 using various data mining techniques. We use linear regression, random forest, gradient boosting, support vector machines, neural networks, and logistic regression to find the best prediction model. There are four categories of food delivery services and we consider two methods. For the first method, we estimate the total number of delivery services and the posterior probabilities of each delivery service. For the second method, we use different models for each category and combine them to estimate the total number of delivery services. The neural network and linear regression model perform best in the first method, this is followed by the neural network which is the best for the second method. The result shows that we can estimate the number of deliveries accurately based on dates and weather information.

Cholesterol과 인지질들로서 제제한 인공세포막에서의 Barbiturates 침투정도

권재영,김해규,정규섭,김인세,김천은 대한마취과학회 1993 Korean Journal of Anesthesiology Vol.26 No.3

소의 신선한 대뇌피질로부터 synapttosomal plasma membrane vesicles(SPMV)를 분리한 후 이 SPMV로부터 추출한 총지질(cholesterol과 각종 인지질 함유)로서 제제한 인공세포막(SPMVTL)에서의 barbiturates 침투 정도를 형광 probe법으로 검색하였다. barbiturates는 SPMVTL 외부 단층(outer monolayer)의 표면에 주로 분포하되 지질용해도와 마취능에 비례하여 소수성 부위에 분포되는 양이 증가되는 현상을 보여주었다. thiopental sodium, pentobarbital, hexobarbital, amobarbital 및 phenobarbital은 SPMVTL외부 단층의 표면(친수성 부위)에 분포되는 것이 소수성 부위에 분포되는 것에 비하여 각각 6.5, 24.1, 25.4, 46.8 및 58.2배가 된다는 것을 확인하였다.

Alpha-2 adrenergic agonist가 백서의 formalin 자극반응에 미치는 효과

권재영 부산대학교 병원 암연구소 1999 부산대병원학술지 Vol.- No.5

제왕절개술시 전정맥마취와 흡입마취의 비교

권재영 부산대학교 병원 암연구소 2001 부산대병원학술지 Vol.- No.9