Cold Stress로 유발된 생쥐의 혈중 corticosterone 농도변화에 대한 사군자탕(四君子湯) 구성약물의 효능

권용욱,이태희,Kwon Yong-Uk,Lee Tae-Hee 대한한의학방제학회 2003 大韓韓醫學方劑學會誌 Vol.11 No.2

This study aimed to investigate the effects of each constituent-herb of Sagoonja- Tang on the plasma corticosterone level in mice exposed to cold stress. Sagoonja-Tang is composed of Ginseng Radix, Atractylodis Radix, Poria, and Glycyrrhizae Radix. Each constisuent-herb(0.5g/kg, 1.0g/kg) was administered intragastrically to mice 1hr prior to expose to forced cold water swimming($4{\circ}C$, 3min) before measuring the change of plasma corticosterone level of mice. The results were as follows: 1. At 30 minutes after the cold stress for 3 minutes the most significant increase of corticosterone level was shown. 2. Ginseng group(PGR group) didn't show any significant changes. 3. Atractylodis group(AR group) showed significant decrease at 0.5g/kg dose (P<0.01). But it didn't show significant changes at 1.0g/kg dose. 4. Poria group(P group) didn't show significant changes. But it showed slightly increase at 1.0g/kg dose. 5. Glycyrrhizae group(GR group) didn't show significant changes. These data revealed that Atractylodis macrocephalae Rhizoma might have the anti-stress effect through the control of plasma corticosterone level and the dose of herbs had a different effect on the plasma corticosterone level in mice exposed to cold stress.

청피(靑皮)가 강제수영부하에 따른 우울행동에 미치는 영향

권용욱 ( Yong Uk Kwon ),이태희 ( Tae Hee Lee ) 대한본초학회 2008 大韓本草學會誌 Vol.23 No.4

Objectives: Investigation of the antidepressant effects of Citri Reticulatae Viride Pericarpium(CR) Methods: In order to investigate the antidepressant effects of Citri Reticulatae Viride Pericarpium(CR), we performed the forced swimming test. Also the expression of CRF, HSP70 and c-fos was measured with immunohistochemical method at PVN. Results: 1. The duration of immobility in the forced swimming test was significantly decreased in the CR 100mg/kg, 400mg/kg groups. 2. In the Control group, CRF expression was significantly increased in the PVN. Also, these CRF increase were significantly reduced in the CR 100mg/kg and 400mg/kg treated group. 3. HSP70 expression was significantly decreased at PVN in the CR 100mg/kg and 400mg/kg treated group. 4. C-fos expression was significantly decreased at PVN in the CR 100mg/kg and 400mg/kg treated group. Conclusions: According to the results, it can be considered that Citri Reticulatae Viride Pericarpium has antidepressant effect.

부신에 발생한 신경절신경종

권용욱(Yong Uk Kwon),이상엽(Sang Yeop Yi),송동우(Woo Dong Song),윤운용(Woon Yong Yoon),정태융(Tae Yung Jeong),김동준(Dong Jun Kim) 대한비뇨기종양학회 2007 대한비뇨기종양학회지 Vol.5 No.3

흉, 요추부 다발성 경막외 지주막낭종: 자기공명 척수조영술을 이용한 경막 결손부의 확인 후 시행한 최소 침습적 수술

권용욱(Yong-Uk Kwon),박대현(Dae-Hyun Park),김동석(Dong-Seok Kim) 대한정형외과학회 2022 대한정형외과학회지 Vol.57 No.5

척추 경막외 지주막낭종(spinal extradural arachnoid cyst, SEAC)은 희귀한 질환으로, 다발성 SEAC는 전 세계적으로 매우 드문 질환이며, 국내에서는 극히 드물게 보고되었다. 저자는 흉부 유형 I 및 요추 유형 II로 진단된 성인에서의 다발성 SEAC 환자에서 수술 전 자기공명 척수조영술(magnetic resonance myelogram)을 사용한 경막 결손 위치의 확인 후 최소 침습적 추궁절제술과 낭종 창냄술을 통해 수술을 시행하였다. 추적 관찰 시 자기공명영상에서 낭종의 크기가 현저하게 감소함이 확인되어 자기공명 척수조영술을 통한 최소 침습적 수술로 광범위 수술 없이 효율적 감압이 이루어짐을 보고하고자 한다. A spinal extradural arachnoid cyst (SEAC) is a rare disease. Multiple SEAC is a very rare disease that has been reported worldwide, mainly in children, but there are few case reports in Korea. The authors report a marked reduction in cyst size on magnetic resonance (MR) imaging at the follow-up after surgery in surgically treated case of a patient diagnosed with thoracic type I and lumbar type II SEAC. After localization of the dural defect using preoperative MR myelograms, a minimally invasive laminectomy and cyst fenestration could prevent many surgical-related complications.

척추에서 발생한 골내 동면종

권용욱(Yong-Uk Kwon),박대현(Dae-Hyun Park),이선주(Sun-Joo Lee),박하영(Ha-Young Park) 대한정형외과학회 2022 대한정형외과학회지 Vol.57 No.6

동면종은 연부조직에서 흔히 발견되는 양성종양으로 척추의 골내 동면종은 드물어 2008년부터 2019년까지 13예밖에 보고되지 않았다. 본 증례에서는 대장암 환자의 전이 병변 여부를 확인하다가 우연히 발견된 척추 골내 동면종에 대하여 생검 및 추시 자기공명영상 검사를 시행하였다. 본 저자들은 척추에 발생한 골내 동면종으로 진단된 증례를 문헌 고찰과 함께 보고하고자 한다. Although hibernomas are commonly found in soft tissues, spinal intraosseous hibernomas are extremely rare and 13 cases have been published from 2008 to 2019. While checking for metastatic lesions in a colorectal cancer patient, a spinal lesion found accidentally, thereafter biopsy and follow-up magnetic resonance imaging were performed. The authors present an intraosseous hibernoma of the spine, which is very rare.

황연해독탕(黃連解毒湯)과 건강부자탕(乾薑附子湯)이 LPS유도에 의한 마우스 혈중 IL-6와 $TNF-{\alpha}$ 변화에 미치는 영향

박수현,권용욱,이태희,Park, Su-Hyun,Kwon, Yong-Uk,Lee, Tae-Hee 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.1

Objective : This study was conducted to investigate the effects of Hwangryunhaedok-Tang and Geongangbuja-Tang on the change of interleukin-6 (IL-6) and tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) level induced by LPS I.C.V. injection in mice. Method : We devided group into 6 mice and 6 mice were assingned to each group. In the normal group only saline was administered intragastrically, and in the control group LPS was injected intracerebroventricularly 1 hr after intragastric administration of saline. In the experiment groups Hwangryunhaedok-Tang(0.5g/kg, 1.0g/kg, 3.0g/kg) was administered intragastrically to mice 1 hr prior to LPS(100mg/mouse) I.C.V. injection.. Also Geongangbuja-Tang (0.5g/kg, 1.0g/kg, 3.0g/kg) was administered intragastrically to mice 1 hr prior to LPS(100mg/mouse) I.C.V. injection. To measure the plasma IL-6 and $TNF-{\alpha}$ level of mice, their blood samples were collected from retro-orbital plexus, immediately centrifuged at $4^{\circ}C$, and plasma was removed and stored frozen at $-83^{\circ}C$ for later determination of IL-6 and $TNF-{\alpha}$. The level of IL-6 and $TNF-{\alpha}$ production was measured by enzyme-linked immunosorbent assay in the plasma. Result : Regarding IL-6 level, The 0.5g/kg and the 1g/kg groups of Geongangbuja-Tang decreased IL-6 level. Especially the 3g/kg control group decreased IL-6 level significantly than the normal group(p<0.01). Regarding $TNF-{\alpha}$ level, the 3g/kg group of Geongangbuja-Tang decreased it significantly(p<0.05). Conclusion : These data revealed that Hwangryunhaedok-Tang might not have the anti imflammatory effect and Geongangbuja-Tang(3g/kg)might have the anti imflammatory effect by reducing the plasma IL-6 and $TNF-{\alpha}$ level in mice LPS Injection.EIM (Eighteen Incompatible Medicaments) is an important component in Oriental pharmacology and is directly related to clinical prescriptions. Medical practitioners argued that the definite cause and meaning of EIM was ambiguous and therefore debated the issue of clinical application of the EIM. This study conducted an in-depth literary research on the origin, meaning and contents of EIM with the purpose to contribute in its efforts to be used clinically. Even after thousands of years have past since establishment of Oriental medicine, EIM is still tabooed and was an obstacle that hindered ideologies. Modern herbal medicine texts claim that the use of EIM can reduce treatment effects and promote poisoning and side effects. However, since long ago, there has been medical practitioners who reject this as false. Recently, poisoning caused by EIM has been claimed to be from the toxicity of the drug itself, rather than the result of interaction between the drugs, and therefore they suggest that EIM is not a forbidden domain. In addition, EIM showed a difference in number depending on the era. However, this can be understood not as a definite number, but instead as a warning to be careful during combination of drugs for use as clinical medicine. Historically, there were very few cases in which EIM was used for clinical tests and thus, the clinical value is not, while others applied EIM directly to their bodies, which showed signs for the usefulness and potential of EIM for us. A more concrete and in-depth study must be made on EIM.

완관절의 초음파 소견 및 이용

김정한,김주용,권용욱,Kim, Jung-Han,Kim, Joo-Yong,Kwon, Yong-Uk 대한정형외과초음파학회 2014 대한정형외과 초음파학회지 Vol.7 No.2

고해상도 초음파 테크닉과 작은 탐촉자들이 개발되면서 표층에 위치하는 작은 구조물들에 대한 검사가 가능하게 되었고, 이로 인하여 초음파는 손목 질환의 진단과 치료에 유용한 도구가 되었다. 초음파를 이용할 때에는 이러한 기술적인 부분 뿐만 아니라 해부학적인 구조와 임상 양상을 잘 이해하여 적용하는 것이 중요하다. 손목의 통증 부위에 따른 대표적인 질환들에 대해 초음파의 접근방법 및 유용성을 정리해보고자 하였다. We can test for small structures located at the surface layer as high resolution ultrasonic techniques and small probes were developed. Accordingly ultrasound became a useful tool in the diagnosis and treatment of wrist diseases. It is important to understand the anatomical structures and apply clinical features as well as these technical aspects when using ultrasound. The purpose of this article is to evaluate the usefulness and approach of ultrasound about typical diseases according to the area of the wrist pain.

무릎 위 절단술 시행 받은 환자의 대퇴골 전자간 골절에서 수술적 방법 - 수술 술기 -

박대현 ( Dae-hyun Park ),권용욱 ( Yong-uk Kwon ),김동석 ( Dong-seok Kim ) 대한골절학회 2021 대한골절학회지 Vol.34 No.4

왼쪽 무릎 위 절단의 수술력이 있는 45세 남자가 낙상 후 왼쪽 고관절 통증을 주소로 응급실에 내원하였다. 일반적으로 사용되는 수술 방법 중 견인 방법을 무릎 위 절단 환자에게 적용할 수 없었기 때문에 수술에 어려움을 겪었다. 저자들은 전자간 골절의 폐쇄 정복 및 내부 고정 중에 Steinmann 핀을 통해 절단된 사지에 견인을 적용하는 거의 사용되지 않는 수술적 기법을 설명하고자 한다. A 45-year-old man with a remote history of a left above-the-knee amputation presented to the emergency department with left hip pain after a mechanical fall. This case was an operative challenge because commonly used intraoperative traction methods could not be applied to a patient with an above-the-knee amputation. We describe a rarely utilized surgical technique of applying traction to an amputated extremity via a Steinmann pin during closed reduction and internal fixation of an intertrochanteric fracture.

역도선수에서 발생한 소능형골 피로 골절

공규민(Gyu-Min Kong),김주용(Joo-Yong Kim),박대현(Dae-Hyun Park),권용욱(Yong-Uk Kwon),정양환(Yang-Hwan Jung) 대한정형외과학회 2015 대한정형외과학회지 Vol.50 No.4

소능형골 골절은 매우 드물게 발생하며 특히 소능형골 골절 단독으로 일어나는 경우는 수근골 골절에서 가장 드문 것으로 알려져 있다. 치료의 원칙 또한 아직 명확히 확립되어 있지 못하다. 대부분의 소능형골 골절은 석고고정을 이용한 보존적인 방법으로 치료할 수 있으며, 전위가 심하거나 다른 수근골 골절과 동반된 경우에는 수술적인 치료가 필요할 수도 있다. 하지만 소능형골의 피로 골절에 대하여 보존적인 방법을 통하여 치료한 경우는 보고된 바 있으나 수술적 치료로 골유합을 얻은 증례는 현재까지 보고된 바 없는 것으로 알려져 있다. 이에 저자들은 역도선수에게 발생한 소능형골의 피로 골절에 대하여 수술적인 치료를 시행하고 결과를 경험하였기에 문헌 고찰과 함께 증례를 보고하고자 한다. Trapezoid fracture is a rare condition and especially, isolated trapezoid fracture is most rare condition of carpal bone fracture. And principle of treatment has not yet been established. Most of trapezoid fractures can be treated using cast but displaced fracture or fracture combined with other carpal bone fractures may require operative treatment. There have been reports about case of conservative treatment in trapezoid stress fracture but no report about case of operative management. We treated a trapezoid stress fracture in a weight lifting athlete by operative treatment and report the results with literature review.

제5 중족골 제1, 2 구역 골절의 조기 체중부하의 비수술적 치료 결과

곽희철(Heui-Chul Gwak),박대현(Dae-Hyun Park),김정한(Jung-Han Kim),이창락(Chang-Rack Lee),권용욱(Yong-Uk Kwon),김동석(Dong-Seok Kim) 대한정형외과학회 2021 대한정형외과학회지 Vol.56 No.2

목적: 제5 중족골 기저부 골절의 위치와 전위, 관절 침범, 분쇄 등의 특징이 조기 체중부하 치료의 결과에 어떤 영향을 미치는지 알아보고자 하였다. 대상 및 방법: 2013년 1월부터 2017년 7월까지 인제대학교 부산백병원에 내원하여 제5 중족골 기저부 제1, 2 구역 골절로 진단받은 총 34명의 34예를 대상으로 하였다. 평균 추시 기간은 13개월(6–15개월)이었다. 동 기간 동안 수술적 치료를 시행한 경우는 없었고 1명의 경우 추시 기간 중 이전 골절 부위와 다른 부위의 재골절로 제외되었으며 총 33예 모두 보존적 치료를 시행하였다. 족부의 전후면, 측면 및 경사 방사선 촬영 및 컴퓨터 단층 촬영을 시행하여 골절의 위치와 전위, 관절 침범, 분쇄의 정도를 평가하였다. 33명의 모든 환자에게 있어서 수상 직후부터 단하지 석고고정 혹은 탈착 가능한 부츠형 보조기를 선택하여 착용 후 통증이 허용되는 범위 내에서 부분적인 체중부하를 허용한 뒤 통증이 소실되면 일반 신발 또는 수술 후 신발을 착용 후 전 체중부하를 시행하게 하였다. 임상적 결과로 최종 추시 시에 American Orthopedic Foot and Ankle Society (AOFAS) score를 평가하였다. 외래 추시 시 족부의 단순 방사선 촬영을 하여 방사선적 골유합 시기와 업무로의 복귀 시기를 확인하였다. 결과: 총 33명의 환자가 본 연구에 참여하였고(남자 9명, 여자 24명), 환자들의 평균 나이는 48.7세(16–80세)였다. 제1 구역이 24명, 제2 구역이 9명이었고 전체 33명의 환자 중 22명에서 2 mm 이상의 골절 전위가 관찰되었고 관절 침범은 9명, 분쇄 골절은 5명에서 관찰되었다. 제1 구역에서 제2 구역에 비하여 통계적 의미 있는 업무로의 복귀를 보였고 최종 추시 시 AOFAS score는 우수한 결과를 보였고 통계적 차이는 없었다. 골절의 전위 정도, 관절 침범 여부, 분쇄 정도를 분류, 비교하였을 때 방사선적 유합 시기, 업무 복귀 시기에 있어 통계적 차이는 없었으며 모든 경우에 있어 최종 추시 시 만족할 만한 결과를 보였다. 결론: 제5 중족골 기저부 골절에서 골절의 위치, 전위, 관절 침범, 분쇄 여부에 관계없이 조기 체중부하를 허용하여도 만족할 만한 임상적 결과를 얻을 수 있다. 제5 중족골 기저부 골절에서 조기 체중부하하 보존적 치료는 우수한 임상 결과를 얻을 수 있는 좋은 치료 방법이라 생각된다. Purpose: To determine how the location, displacement, intra-articular involvement, comminution of a 5th metatarsal base fracture affect results of early weight-bearing treatment. Materials and Methods: From January 2013 to July 2017, 34 cases of 34 patients diagnosed with a fracture of the zone I and II 5th metatarsal base were enrolled. The mean follow-up period was 13 months (6–15 months). One patient was excluded as a refracture during the follow-up period, and 33 patients underwent conservative treatment. Anteroposterior, lateral, and simple oblique radiography and computed tomography of the foot were performed to evaluate the location and displacement of the fracture, the degree of joint involvement, and comminution. In all 33 patients, a short leg cast or boot brace was selected immediately after the injury, tolerable weight bearing was allowed. If the pain disappeared, full weight bearing was performed after wearing a plain shoe or postoperative shoe. As a clinical result, the American Orthopedic Foot and Ankle Society (AOFAS) score was evaluated at the final follow-up. During outpatient follow-up, a simple radiograph of the foot was taken to confirm the time of radiological bone union and return to work. Results: Nine males and 24 females, with an average age of 48.7 years, were enrolled in the study. Twenty-four patients had zone I fractures, and nine patients had zone II fractures. Twenty-two out of 33 patients had a fracture displacement of 2 mm or more. Nine and five patients had joint involvement and comminution, respectively. There was a statistically significant return to work from zone I to zone II. The AOFAS score was excellent at the final follow-up and there was no significant difference. When classifying and comparing the degree of fracture displacement, joint involvement, and comminution, there were no significant differences in the radiological union time and return to work. In all cases, satisfactory results were obtained at the final follow-up. Conclusion: Satisfactory clinical results can be obtained by allowing early weight-bearing regardless of the fracture location, displacement, joint involvement, or comminution in zone I and II 5th metatarsal base fractures.