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권영삼,장광호,김정은,채형규,임재현,이근우,장인호 한국임상수의학회 1999 한국임상수의학회지 Vol.16 No.2
The effects of continuous administration of propofol on the blood, liver and kidney of dogs were evaluated. Propofol(5mg/kg) was repeatedly administered to 8 mongrel dogs intravenously for consecutive seven days. Time to recovery, body temperature, heart rate, and respiratory rate were measured and recorded during experimental period. Hematology (WBC, RBC, PCV) and serum chemistry (AST, ALT, BUN, Creatinine) were also monitored for eight days. Time to standing significantly decreased on day 4 and 6 compared with that on day 1. Body temperature 5 minutes after injection on day 5 and 6, and respiratory rate before injection on day 2, 3, 5 and 6 were significantly increased, respectively. No significant changes were observed in total WBC counts, total RBC counts and PCV values. The AST and AIT values were decreased on day 2 compared with those on day 1, but were within clinically normal range. There were no significant changes in BUN and Creatinine levels. This study suggests that consecutive day propofol anesthesia in dogs can be used for the purpose of the treatment and restraint.
권영삼,장광호,장인호 한국임상수의학회 2002 한국임상수의학회지 Vol.19 No.3
Intranasal tumors were diagnosed in 27 dogs for 5 years. Sneezing, nasal discharge, nasal bleeding were the most common clinical signs. Diagnosis was performed by blood test, histological examination, radiography, and computed tomography. Among the 27 nasal tumors, adenocarcinomas, squamous cell carcinomas, and chondrosarcomas were relatively common. Breeds with nasal tumor were shetland sheepdog, mongrel, and shiba. The dogs were treated by surgical resection, radiotherapy, chemotherapy, cryosurgery, and radiofrequency ablation. Each therapy alone was not effective, but the combination of two or more therapies had good effects on progression of tumor and made the survival time extended.
Large time behavior for the degenerate compressible Navier-Stokes equations with damping
권영삼 대한수학회 2019 대한수학회보 Vol.56 No.3
In this paper we consider degenerate compressible Navier-Stokes equations giving rise to a variety of mathematical problems in many areas. We study the long time behavior for the degenerate compressible Navier-Stokes equations with damping.
The quasi-neutral limit of the compressible magnetohydrodynamic flows for ionic dynamics
권영삼 대한수학회 2019 대한수학회지 Vol.56 No.6
In this paper we study the quasi-neutral limit of the compressible magnetohydrodynamic flows in the periodic domain $\mathbb{T}^3$ with the well-prepared initial data. We prove that the weak solution of the compressible magnetohydrodynamic flows governed by the Poisson equation converges to the strong solution of the compressible flow of magnetohydrodynamic flows as long as the latter exists.
개에서 Sodium Carboxymethylcellulose와 Low Molecular Weight Heparin(Fraxiparine$^{(R)}$)의 유착방지효과
권영삼,장인호 한국임상수의학회 1999 한국임상수의학회지 Vol.16 No.1
This study was carried out to compare the efficacy of sodium carboxymethyl cellulose (SCMC) with the combination of low molecular weight heparin (LMWH) and SCMC for the prevention of postoperative adhesions in the dog. After laparotomy, abrasions were made on the surface of ileal serosa in 17 dogs. The animals were randomly divided into the control group (N = 5) which received no treatment, the SCMC-treated group (N = 6), and the SCMC & LMWH-treated group (N = 6). Hematologic values were monitored before laparotomy and 1, 4, 7, 10 and 14 days after laparotomy. The location and score of adhesion were assessed at second laparotomy 3 weeks later, Although the mean adhesion score both in the SCMC-treated group (7.17${\pm}$1.17) and in the SCMC & LMWH-treated group (4.50${\pm}$1.38) was found to be significantly lower than that in the control group (9.40${\pm}$0.89) (p<0.01 and p<0.01, respectively), more favorable adhesion prevention was achieved in the SCMC & LMWH-treated group in comparison with the SCMC-treated group without any hemor-rhagic complications (p<0.01). This study could conclude that SCMC & LMWH are highly effective in prevention against postoperative adhesion in the dog.
BMP-2와 GDF-5의 Rat 골수 유래 중간엽 줄기세포의 골 분화 효과 비교
권영삼,유정준,전흥재,김희중 한국조직공학과 재생의학회 2009 조직공학과 재생의학 Vol.6 No.13
Recently, it has been reported that growth and differentiation factor-5 (GDF-5) regulates and promotes osteoblastic and osteogenic differentiation. We here compared effects of GDF-5 and BMP-2 on the proliferation and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBM-MSCs). Cell proliferation was significantly increased in BMP-2 and GDF-5 treated group compared to those in control group. The ALP activities of osteogenic differentiation group, BMP-2 treated group, and GDF-5 treated group was higher than in control group. The ALP activity of GDF-5 group was similar with that of BMP-2 group. When the Ca activity was compared in all groups, the Ca level of GDF-5 group was highest and was similar with that of BMP-2 group. As a result of Von Kossa staining and RT-PCR, the calcium deposition and osteogenic gene expression were increased in the GDF-5 group than in the osteogenic differentiation group. In the present study, GDF-5 appears to be an effective stimulator of proliferation and osteogenic differentiation of rBM-MSCs. To this regard, GDF-5 may be a useful regulator for promoting the bone regeneration and formation by inducing rBM-MSCs proliferation and osteogenic differentiation. Recently, it has been reported that growth and differentiation factor-5 (GDF-5) regulates and promotes osteoblastic and osteogenic differentiation. We here compared effects of GDF-5 and BMP-2 on the proliferation and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBM-MSCs). Cell proliferation was significantly increased in BMP-2 and GDF-5 treated group compared to those in control group. The ALP activities of osteogenic differentiation group, BMP-2 treated group, and GDF-5 treated group was higher than in control group. The ALP activity of GDF-5 group was similar with that of BMP-2 group. When the Ca activity was compared in all groups, the Ca level of GDF-5 group was highest and was similar with that of BMP-2 group. As a result of Von Kossa staining and RT-PCR, the calcium deposition and osteogenic gene expression were increased in the GDF-5 group than in the osteogenic differentiation group. In the present study, GDF-5 appears to be an effective stimulator of proliferation and osteogenic differentiation of rBM-MSCs. To this regard, GDF-5 may be a useful regulator for promoting the bone regeneration and formation by inducing rBM-MSCs proliferation and osteogenic differentiation.
세라믹 분말 성형체의 크리프 치밀화 및 결정립 성장의 해석
권영삼,김기태 한국세라믹학회 1993 한국세라믹학회지 Vol.30 No.4
A constitutive model is proposed to analyze creep densification and grain growth of ceramic powder compacts. The creep strain rates for powder compacts are obtained from constitutive equations proposed by Rahaman et al. and Helle et al. The grain-growth rate is obtained by assuming time, grain size, and strain rate as its internal state variables. the proposed constitutive model is compared with experimental data for alumina compacts obtained by Venkatachari and Raj for sinter forging and by Son et al. for hot pressing.