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Hydrogen Peroxide로 유도된 산화성 간세포 손상에 대한 Propofol과 Etomidate의 효과
이은호 ( Eun Ho Lee ),신진우 ( Jin Woo Shin ),윤선경 ( Sun Kyung Yoon ),손효정 ( Hyo Jung Son ),이지연 ( Ji Yeon Lee ),구승우 ( Seung Woo Ku ),김종욱 ( Joung Uk Kim ),이유미 ( Yu Mi Lee ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.3
Background: The present investigation was undertaken to evaluate the protective effect of propofol and etomidate against hydrogen peroxide (H2O2) induced oxidative damage in human hepatic SNU761 cells by measuring lactate dehydrogenase (LDH). Methods: The cell line of human hepatocellular carcinoma was grown for 24 hours in dissociated cell culture. They were divided into eight groups: negative control (NC) group with no drug administration, positive control (PC) group with H2O2 250 μM and other groups pretreated with propofol (P; 1, 10, 50 μM) or etomidate (ET; 1, 10, 50 μM) followed H2O2 administration. After 7 hours, cell death was assessed by morphology under the light microscope and quantified by measuring the LDH in the culture media. Results: In the light microscopic findings, the intact cells were increased in all three propofol groups compared to group PC. H2O2-induced LDH production was also significantly suppressed in all three propofol groups compared to group PC (P<0.001). There were no significant differences in the microscopic findings and LDH production between the etomidate groups and group PC. Conclusions: These results suggest that the propofol has protective effect on the hepatocyte against H2O2-induced oxidative stress. (Korean J Anesthesiol 2009;57:331∼6)
심장수술 시 농축적혈구, 자가수혈기 혈액, 체외 순환기 혈액에서의 유리 혈색소 농도 비교
송장호,구승우,백종화,정용보,이정순,최인철 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.5
Background: Intraoperative autotransfusion or residual blood in a cardiopulmonaty bypass (CPB) circuit has been used to reduce the need for an homologous blood transfutsion during cardiac surgery. However, it may contain some free hemoglobin released from damaged cells. The load of blood containing free hemoglobin may cause renal dysfunction. We measured the amount of free hemoglobin in backed blood, cell saver blood and CPB blood to evaluate what is the least hemolytic blood transfused in cardiac surgery. Methods: This study was performed in 20 patients undergoing cardiac surgery. In each patient, the banked blood, intraoperative salvaged blood with a cell saver and CPB residual blood were sampled at the end of the operation. The concentration of free hemoglobin, hemoglobin and platelet counts were measured in these blood samples and percent of hemolysis was calculated (%hemolysis = [free hemoglobin] / .free hemogloben + hemoglobin]) Results: In salvaged blood with a cell saver, CPB residual blood and banked blood, hemoglobin concentrations were 20.1 ± 2.7 g/dl, 8.0 ± 1.1 g/dl, and 22.2 ± 2.7 g/dl, respectively. Free hemoglobin concentrations were 336.6 ± 239.5 mg/dl, 49.2 ± 26.8 mg/dl, and 279.5 ± 167.5 mg/dl respectively. Platelet counts were 26.1 ± 22.2 × 10^3/mm^3, 116.8 ± 56.5 × 10^3/mm^3, and 94.9 ± 43.6 × 10^3/mm^3 respectively. % Hemolysis were 1.6 ± 1.1%, 0.6 ± 0.4%, and 1.2 ± 0.7% respectively. In the comparison between the salvaged blood with a cell saver and CPB residual blood, free hemoglobin concentration, % hemolysis, and platelet counts had positive correlations (r = 0.8, 0.7, and 0.6). Conclusions: In twenty cardiac surgeries, CPB residual blood had a lower free hemoglobin level than the other two blood groups. The platelet counts in CPB residual blood were higher than those in cell saver blood but did not differ from those in banked blood. Therefore, CPB residual blood was the least hemolytic blood among the three blood groups when a transfusion was performed in cardiac surgery. (Korean J Acesthesiol 2002; 43: 588~593)
Etomidate 와 Propofol 이 백서 단일심근 세포의 칼슘 전류에 미치는 영향
한성민,최인철,이은주,김원태,이소영,김종욱,구승우 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.39 No.1
Background : Cardiovascular instability after induction of intravenous anesthetics may be explained partly by direct negative inotropic effects. We studied the effects of etomidate and propofol on the inward calcium currents (1c,) of rat ventricular myocytes using the whole-cell voltage-clamp technique. Methods : Ic, was elicited by progressively depolarizing cells from -40 to +50 mV. The peak amplitude of Ic, wss measured before, during and after the administration of equirnolar concentrations of etomidate and propofol. Results : Exposure to etomidate and propofol produced a cancentration-dependent inhibition of Ic., 1, 10, 100 and 300 p M of etomidate decreased the peak Ic, (mean±SEM) by 14.5±6.3, 25.9±9.4, 31.9±12.1, 42.5±8.8% and 1, 10, 100 and 300 p M of propofol decreased the peak 4, by 15.7 ±3.4, 21.3-2.5, 59.2±2.0, 69.9±2.8%, respectively. Conclusions : These results suggest that etomidate and propofol have a direct negative inotropic effect via inhibition of inward calcius in rat ventricuiar myocytes. (Korean J Anesthesiol 2000; 39: 111 ~ 118)