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최근 5년간 내원한 주사 환자 133예에 관한 임상적 고찰
구본식,권호준,김병천,이규석,송준영 ( Bon Sik Koo,Ho June Kwon,Byung Chun Kim,Kyu Suk Lee,Joon Young Song ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.3
Background: A clinical study of rosacea has never been reported in Korea. Objective : The purpose of this study was to elucidate the clinical observations of rosncea. Methods : During a 5-year-period from Jan. 1990 to Dec. 1994, 133 patients were evaluated with regard to age, sex, location of skin lesions, clinical type, duration, and precipitating factors. Results & Conclusions : 1. Of the 7,787 cases amongst outpatients, 133 cases(1.7% ) were dignosed with rosacea. Of there 46 were male patients and 87 females, giving a sex ratio of 1:1.9 in favor of females. 2. The most common type of rosacea was vascular rosacea(60.2%) 3. The average duration of rosacea was 3.4 years. 4. Rosacea afflict persons aged 40-49 most frequently. 5. The predilection sites of the rosacea were : cheek(42.9%), nose(23.3%), entire face(11.3%), cheek & nose(9%), zygomatic area(6.8%), extra-facial area(3.8%), forehead(2.9%). 6, The aggravating factors of rosacea were : unknown cause(32.3%), coffee & tea(18%), alcohol(13.5%), emotional stress(10.5%), sun exposure(9.8%), multi-factoral(7.5%), drugs(steroids) (4.6%). (Kor J Dermatol 1997;35(3): 405-410)
배양된 피부 각질형성세포에서 nuclear factor kB ( NFkB ) 와 AP - 1 의 활성도에 대한 자외선 B의 효과
구본식,류영욱,이규석 ( Bon Sik Koo,Young Wook Ryoo,Kyu Suk Lee ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3
Background: Ultraviolet B(UVB) light, which can cause severe damage like induction and promotion of cancer, cutaneous inflammation and immunosuppression, represents one of the most important environmental impacts for humans. Keratinocytes are natural target cells of UVB in humans. NF-kB plays a role in the cell of the immune system, where it controls the expression of various cytokines and the major histocompatibility complex gene. Objective : The purpose of this study was to examine the effect of UVB on the NF-kB and AP-1 activity in cultured human keratinocytes and fibroblasts. Methods : Keratinocyte and fibroblast cultures were produced with DMEM medium. Cells were irradiated for 100J/m, 200J/m, 300 J/m. and Nuclear proteins were extracted. AP-1 and NF-kB activities were measured by the gel shift mobility assay. Results : Gel shift mobility assay. 1. The NFkB activity was increased upon UVB in a dose dependent manner in the keratinocyte. 2. Enhanced levels of AP-1 binding activity in the radiated extracts frorn human skin keratinocytes were detected. 3. The levels of GRE(glucocorticoid responsive element) binding activity were similar in both radiated and unradiated extracts from fibroblasts and keratinocytes. Conclusions : The activities of NF-aB and AP-1 are increased following stimulation of a cell with UVB irradiation. Therefore, UV induced skin tumors, abnormal cell proliferation, cutaneous inflammation and immunosuppression, may be due to these transcriptional factors. (Kor J Dermatol 1997;35(3): 411-417)
Triamcinolone Acetonide 병변내 주사로 호전을 보인 화농성 육아종
구본식 ( Bon Sik Koo ),김창욱 ( Chang Wook Kim ),신문석 ( Moon Seok Sihn ),류영욱 ( Byung Chun Kim ),김병천 ( Kyu Suk Lee ),이규석 대한피부과학회 1998 대한피부과학회지 Vol.36 No.3
We observed a 55-year-old man who had granuloma pyogenicum on the medial border of the right fifth toe which developed after scratching of the wound. Histopathological findings showed many newly formed capillaries that had prominant endothelial cells and showed varying degrees of dilation without appearance of epidermal collarette signs. We tried intralesional treatment with triamcinolone acetonide (10mg%, 1/week*3). After 3 sessions of treatment, the lesion dramatically regressed nearly to normal size. (Korean J Dermatol 1998;36(3): 545-547)
신문석,구본식,권호준,김병천,이규석 ( Moon Seok Sihn,Bon Sik Koo,Ho June Kwon,Byung Chun Kim,Kyu Suk Lee ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3
Ecthyma Gangrenosum is a rapidly progressing skin infection charact,erized by edema, hemorragic bullae and necrosis. Ecthyma Gangrenosum occurs almost exclusively in severely imrnunocompromised patients during the course of pseudomanas aeruginosa septisemia. A 5 month-old boy was transferred to our department because of multiple well defined central necrotic black-colored large erythematous bullae. In the bacterial cultures of skin, stool and liver aspiration fluid, Pseudomonas aeruginosa was grown. In the abdominal ultrasonogram and computed tomogram, the multiple liver abscess, hepatomegaly and ascites were shown on both hepatic lobes. Herein we report a case of ecthyma gangrenosum associated with liver abscess. (Kor J Dermatol 1997;35(3): '.41-545)
공수득,구본식,김병천,이규석 ( Soo Deuk Kong,Bon Sik Koo,Byung Chun Kim,Kyu Suk Lee ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3
Vesiculobullous eruptions are a rare cutaneous manifestation of systemic lupus erythematosus (SLE). They are related to intense inflammation within the cutaneous lesions and subsequent blister formation. We report a case of vesiculobullous eruption of SLE in a 23-year-old male. The bullous eruptions were present ori the lip, forehead, both feet and hands. He met ARA(American Rheumatism Association) is criteria for a diagnosis of SLE and the eruptions developed during a systemic attack of the disease. Routine histology of the lesion showed subepidermal blisters with intact epidermis and dense neutrophilic infiltration in the upper dermis. Direct immunofluorescence of lesional skin showed a linear-granular pattern of immune deposits at the dermoepidermal junction. Electronmicroscopy of the lesional skin showing subepidermal bullae are located beneath the lamina densa. Combination therapy of prednisolone and hydrochloroquine showed complete clearing of the lesions within several weeks. We observed a good response without evidence of recurrence. (Kor J Dermatol 1997;35(3): 588-592)
具本植 영남이공대학 1980 論文集 Vol.9 No.-
Two-phase, gas-liquid concurrent down-flow in packed column was investigated to measure pressure loss and friction factor nearby trickle-flow region with packing material whose diameter smaller than 3mm. The investigations were carried out in packed acryl column, 3.6 cm diameter and 30cm in height, with glass beads. The packings were used 1.31, 0.79 and 0.595 mm as equivalent diameter of based on sphere. Two-phase pressure loss, dPr/z. was given in terms of gas flow rate, liquid flow rate, void fraction, packing size and liquid hold-up as following equation. 4 p t/z= 2 le e ,dpy At-r(t?e)=Rel. where, Ref = 32 . or um de g,.h.¢(t?e) Two-phase pressure loss (dPr/z) was measured from experiments, and it was inserted in above equation. Finally, an empirical relation between the two-phase friction factor (It) and Rer was found to be as followings, fr?Re:-r.,c