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최경호,이은봉,유창달,백한주,광성욱,신기철,이연정,김현아,전주홍,김채완,신동명,김인규,송영욱 생화학분자생물학회 2005 Experimental and molecular medicine Vol.37 No.6
Filaggrin is expressed in the cornified layer of epidermis and known to be one of the antigenic targets in rheumatoid arthritis. Although the citrul-line residue in filaggrin is thought to be an antigenic determinant recognized by autoantibodies, the diagnostic sensitivity of synthetic citrullinated peptide is variable. To investigate the implication of anti-filaggrin antibodies recognizing uncitrullinated filaggrin in rheumatoid arthritis, we assayed anti-body titers using unmodified recombinant filaggrin in the sera from 73 patients with rheumatoid arthritis, 150 patients with other connective tissue diseases and 70 normal controls. We also performed the correlation analysis between antibody titers and the clinical variables in patients with rheumatoid arthri-tis. Titers of IgG anti-filaggrin antibodies were signi-ficantly higher in rheumatoid arthritis patients compared to normal controls (P = 0.02), but not in patients with osteoarthritis, ankylosing spondylitis or systemic lupus erythematosus. IgG anti-filaggrin antibodies were more frequently found in patients with rheumatoid arthritis compared to normal controls (12.3% vs 1.4% respectively, P = 0.04). Ananti-filaggrin antibody titer was correlated with visual analogue scale of pain, tender joint count, Ritchie articular index or C-reactive protein, but not with anti-nuclear antibody or rheumatoid factor. These results suggest that anti-filaggrin antibody recog -nizes the uncitrullinated filaggrin as an antigen and its titer correlates with clinical parameters, explain-ing the variable sensitivity of anti-filaggrin antibody test.
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