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한국 성인에서 비타민 D와 흔한 만성질환 지표 간의 연관성
윤혜령,곽혁신,나은희,조치현 대한진단검사의학회 2023 Laboratory Medicine Online Vol.13 No.3
Background: Vitamin D receptors exist in all cells throughout the human body regulating transcription and expression of various target genes. Recent studies have focused on the potential novel functions of vitamin D other than bone metabolism. We attempted to identify the status of vitamin D deficiency in Korean adults and elucidate associations between vitamin D and indicators of common chronic diseases, such as obesity, dyslipidemia, fatty liver, hypertension, diabetes, kidney disease, and depression. Methods: From August to December 2021, 4,545 individuals (1,653 men and 2,892 women) over the age of 20 were studied. Serum total 25-hydroxyvitamin D was measured using an electrochemiluminescence immunoassay with a 25-hydroxyvitamin D kit (Roche Diagnostics, Germany). The corresponding results of a mental health questionnaire, waist circumference, body mass index, and blood pressure were collected, alongside blood levels of total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, AST, ALT, γ-GT, fasting blood glucose, HbA1c, and creatinine. Results: Vitamin D levels increased with age. Prevalence of vitamin D deficiency (<10 ng/mL) was the highest among people in their 20s. Overall, vitamin D levels were under 30 ng/mL in 83.7% of men and 73.4% of women. Vitamin D was inversely associated with waist circumference, body mass index, systolic blood pressure, γ-GT, total cholesterol, triglycerides, and LDL-cholesterol (each, P<0.001). Meanwhile, vitamin D was positively associated with HDL-cholesterol (P=0.002). Conclusions: Lower serum vitamin D levels led to stronger associations with indicators of obesity, dyslipidemia, hypertension, and fatty liver. Ultimately, this suggests that vitamin D deficiency is associated with metabolic syndrome.
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