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유중수 타입의 외관이 투명한 자외선 차단 화장료에 관한 연구
곽재훈,조용훈,변상요,김태훈,Kwak, Jae-Hoon,Cho, Yong-Hun,Byun, Sang-Yo,Kim, Tae Hoon 한국응용과학기술학회 2015 한국응용과학기술학회지 Vol.32 No.3
본 연구는 내수성을 지니고 사용 시 백탁 현상이 없는 투명한 외관을 가지는 자외선 차단 화장료 제재를 개발 하는 방법이다. 외관이 투명한 자외선 차단제는 유화물의 수상부와 유상부의 굴절률 차이에 따른 투명도를 통하여 외관이 투명한 유중수 타입의 자외선 차단제를 연구하였다. 지속성 및 내수성이 우수한 유중수 타입의 에멀젼을 연구하고 제형의 수상부 및 유상부의 비율을 조정하여 유중수형 유화의 안정성을 극대화시키는 방향으로 제형을 설계하는 연구를 수행 하였다. 연구 결과, 수상부와 유상부의 굴절률 차가 0.004이하일 때 투명한 유중수형 에멀전을 형성 할 수 있었으며, 내상부인 수상의 함량이 70% (w/w) 이상에서 안정한 유중수형 에멀젼을 형성하였다. 임상 시험을 통하여 투명한자외선차단제의 자외선 A 차단지수와 자외선 B차단 지수를 측정하였다. 그 결과, 자외선 A 차단지수는 $3.01{\pm}0.30$ 으로 나타났으며, 자외선 B 차단지수는 $30.99{\pm}1.65$로 측정되었다. This study is related to the developing method of a transparent sunscreen cosmetic which has waterproofing property and no white turbidity when applied to skin. The transparent sunscreen is prepared by exploiting refractive index difference between oil-phase and water-phase of water-in-oil(W/O) emulsion. The sunscreen according to this study is prepared as a W/O type emulsion so that it is water-stable and water resistance. Also, the stability of W/O type emulsion is developed by adjusting the content of oil phase part and water phase part. As a result of this studying, the transparent W/O emulsion is prepared by adjusting the refractive index of oil-phase and water-phase within 0.004 and it is found that the stability of the transparent sunscreen is increasing when the water phase part is over 75% (w/w) of the W/O emulsion. Through clinical test of transparent sunscreen, the value of sun protection Factor(SPF) and Protection Factor of UVA(PFA) were determined. SPF and PFA values of transparent sunscreen were indicated $30.99{\pm}1.65$ and $3.01{\pm}0.30$.
심방세동 환자에서 새로 개발된 R2CHA2DS2-VASc score 유용성 및 CHADS2, CHA2DS2-VASc scores와의 비교연구
곽재훈 ( Jae-hoon Kwak ),여세환 ( Se-hwan Yeo ),김여운 ( Yeo-un Kim ),이진석 ( Jin-suk Lee ),김병규 ( Byong-kyu Kim ),정진욱 ( Jin-wook Chung ),배준호 ( Jun-ho Bae ),나득영 ( Deuk-young Nah ),이관 ( Kwan Lee ) 영남대학교 의과대학 2016 Yeungnam University Journal of Medicine Vol.33 No.1
Background: The decision to administer oral anticoagulation therapy depends on accurate assessment of stroke risk in patients with atrial fibrillation (AF). Various stroke risk stratification schemes have been developed to help inform clinical decision making. The CHADS2 and CHA2DS2-VASc scores have been used in estimating the risk of stroke in patients with AF. Recently R2CHA2DS2-VASc score was developed. The objective of the current study is to validate the usefulness of the R2CHA2DS2-VASc score and to compare the accuracy of the CHADS2, CHA2DS2-VASc, and R2CHA2DS2-VASc scores in predicting a patient’s risk of stroke. Methods: Based on medical records, we conducted a retrospective study of patients hospitalized with AF from March 2011 to July 2013. A total of 448 AF patients were included in this study. The receiver operating characteristic (ROC) curve analysis in MedCalc was used for comparison with respective diagnostic values. Results: The patient characteristics showed male predominance (60.9%). Among the 448 AF patients, 131 (29.2%) patients had strokes during the study. A R2CHA2DS2-VASc score of more than 5 is the optimal cut-off value for prediction of stroke. A risk score of three, the area under the ROC curve (AUC) of R2CHA2DS2- VASc score (AUC 0.631; 95% confidence interval, 0.585-0.679) was the highest. A significant difference was observed between AUC for R2CHA2DS2-VASc, CHADS2, and CHA2DS2-VASc scores, but no meaningful difference between CHADS2 and CHA2DS2-VASc scores. Conclusion: We determined the usefulness of the R2CHA2DS2-VASc score, which showed better association with stroke than the CHADS2 and CHA2DS2-VASc scores.
여세환 ( Se Hwan Yeo ),곽재훈 ( Jae Hoon Kwak ),김여운 ( Yeo Un Kim ),권태호 ( Tae Ho Kwon ),박정배 ( Jeong Bae Park ),박준형 ( Jun Hyung Park ),이용국 ( Yong Kook Lee ),임윤정 ( Yun Jeong Lim ),양창헌 ( Chang Heon Yang ) 대한소화기학회 2016 대한소화기학회지 Vol.67 No.4
목적: 기존에 널리 사용된 PEG의 단점을 보완하고자 새롭게 도입된 PEGA에 있어 점막 내 기포 제거에 주안점을 둔 연구가 없었다. 이에 이번 연구에서 기포 제거제인 simethicone추가군과 대장 점막의 flushing 효과를 기대한 물 1리터 추가군을 두어 대장 정결도, 점막 기포도, 부작용, 환자 만족도 등을 알아보고자 하였다. 대상 및 방법: 전향적 무작위 대조 연구이며, 건강 검진을 위해 내원한 외래 수검자 90명의 환자 중 각각 30명씩 PEGA군, simethicone 추가군, 물 1리터 추가군에 무작위로 배정하여 대장 정결도, 점막 기포도, 환자가 호소하는 부작용 및 만족도를 평가하였다. 결과: PEGA군에서 대장 정결도가 가장 높았으나, 통계적 유의성은 없었다. 점막 기포도는 세 군에서 2.57±2.05 vs.1.10±1.83 vs. 2.60±2.84로 나타났으며, simethicone 추가군이 통계적으로 유의하게 점막 기포도가 낮은 것으로 나타났다(p=0.017). 환자가 호소하는 부작용은 세 군에서 20.0%vs. 16.7% vs. 53.3%로 나타났으며, 물 1리터 추가군이 다른두 군에 비해 통계적으로 유의하게 많은 것으로 나타났다(p=0.003). 환자의 만족도는 세 군에서 3.37±0.85점, 3.73±0.74점, 3.20±0.66점으로 나타났으며, 이들 중 simethicone추가군이 물 1리터 추가군보다 통계적으로 유의하게 높은 것으로 나타났다(p=0.020). 결론: PEGA가 복용량의 감소에도 불구하고 수긍할 만한 대장 정결도를 보였으며, 점막 기포 제거에 있어서 simethicone병합요법이 필요할 것으로 판단된다. Background/Aims: There are no studies that looked into the bubble eliminating efficacy of polyethylene glycol with ascorbic acid (PEGA), which has been one of the shortcomings of polyethylene glycol (PEG). In this study, we compared newly introduced PEGA regimen by adding either simethicone or 1 L of water. Methods: A prospective randomized controlled study was carried out at Dongguk Universtiy Gyeongju Hospital from July 2014 to September 2014. A total of 90 patients were randomly assigned to 3 groups; PEGA group (n=30) which served as control, simethicone addition group (n=30) to which simethicone 400 mg was additionally prescribed, and water addition group (n=30) to whom additional 1 L of water was given. Cleansing effectiveness, gas elimination efficacy, side effects, and patient satisfaction were compared between the groups. Results: PEGA group demonstrated the highest cleansing effectiveness, but there was no statistically significant difference among the groups. Simethicone addition group showed significantly lesser amount of bubbles than the other groups (2.57±2.05 vs. 1.10±1.83 vs. 2.60±2.84, p=0.017). The rates of side effects in each group were 20.00% vs. 16.77% vs. 53.33%. Water addition group had significantly more side effects than the PEGA group and the simethicone addition group (p=0.003). The patient satisfaction score of each group was 3.37±0.85 vs. 3.73±0.74 vs. 3.20±0.66 with simethicone addition group showing significantly higher satisfaction than water addition group (p=0.020). Conclusions: PEGA bowel preparation agent showed satisfactory bowel cleansing despite the decrease in dosage, and addition of simethicone resulted in better bubble elimination. (Korean J Gastroenterol 2016;67:189-197)
단풍취 추출물 및 분획물의 항산화 및 α-glucosidase 저해 활성 평가
이은우,김태완,김현석,박윤문,김성호,임무혁,곽재훈,김태훈,Lee, Eun-Woo,Kim, Taewan,Kim, Hyun-Seok,Park, Youn-Moon,Kim, Seong-Ho,Im, Moo-Hyeog,Kwak, Jae Hoon,Kim, Tae Hoon 한국식품저장유통학회 2015 한국식품저장유통학회지 Vol.22 No.2
Among the naturally occurring antioxidants, polyphenols are widely distributed in various fruits, vegetables, wines, juices, and plant-based dietary sources and divided into several subclasses that included phenolic acid, flavonoids, stilbenes, and lignans. As part of our continuing search for bioactive food ingredients, the antioxidant and ${\alpha}$-glucosidase inhibitory activities of the aqueous ethanolic extract from the aerial parts of Ainsliaea acerifolia were investigated in vitro. The antioxidant properties were evaluated via radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) ($ABTS^+$) radicals. In addition, the anti-diabetic effect of A. acerifolia extracts was tested via ${\alpha}$-glucosidase inhibitory assay. Furthermore, the total phenolic contents were determined using a spectrophotometric method. All the tested samples showed dose-dependent radical scavenging and ${\alpha}$-glucosidase inhibitory activities. In particularly, the ${\alpha}$-glucosidase inhibitory and radical scavenging properties of the ethyl acetate (EtOAc)-soluble portion from the aerial parts of the A. acerifolia were higher than those of the other solvent-soluble portions. These results suggest that A. acerifolia could be considered a new potential source of natural antioxidants and antidiabetic ingredients. More systematic investigation of the aerial parts of A. acerifolia will be performed for the further development of anti-oxidative and antidiabetic drugs. 단풍취를 70% 에탄올로 침지 추출하여 얻어진 추출물에 대해 n-hexane, EtOAc 및n-BuOH로 순차 용매 분획하였고, 얻어진 결과물에 대하여 DPPH와 $ABTS^+$ radical 소거능 및 ${\alpha}$-glucosidase 저해활성을 평가하였다. DPPH 라디칼 소거능은 페놀성 화합물의 함량이 상대적으로 높은 EtOAc층에서 $IC_{50}$ 값이 $23.4{\pm}0.3mg/mL$으로 강한 DPPH 라디칼 소거능을 확인하였고, 단풍취 추출물에 존재하는 페놀성 화합물과 라디칼 소거능과의 연관성을 시사하였다. 또한 $ABTS^+$ 라디칼 소거능은 EtOAc층의 $IC_{50}$ 값이 $19.9{\pm}2.3mg/mL$, n-BuOH층이 $IC_{50}$ 값이 $23.4{\pm}0.3mg/mL$의 우수한 라디칼 소거활성이 확인 되었고, 강한 활성물질의 존재가 시사되었다. 또한, ${\alpha}$-glucosidase 저해활성을 측정한 결과, 강한 $ABTS^+$ 라디칼 소거능을 나타낸 EtOAc 층의 $IC_{50}$은 $103.4{\pm}1.0mg/mL$의 저해활성을 나타내었으며 이는 positive control인 acarbose에 비해 우수한 활성이었으며, 추출물 상태의 시료를 단일물질로 정제할 경우 더욱 강한 효능의 화합물이 존재할 가능성을 시사하였다. 향후 이들 활성물질 동정을 통한 활성 기작에 대한 연구가 필요하며 본 연구 결과는 보다 우수한 라디칼 소거능 및 ${\alpha}$-glucosidase 저해능을 가지는 새로운 기능성 식품소재 발굴을 위한 기초자료로 활용가능하리라 사료된다.
안봉전 ( Bong Jeun An ),이진태 ( Jin Tae Lee ),곽재훈 ( Jae Hoon Kwak ),박정미 ( Jung Mi Park ),이진영 ( Jin Young Lee ),박태순 ( Tae Soon Park ),손준호 ( Jun Ho Son ),이임식 ( Lim Sik Lee ),윤숭섭 ( Sung Seob Yun ) 대한본초학회 2004 大韓本草學會誌 Vol.19 No.2
N/A Objectives : The physiological activities of Pumpkin(Cucurbita moschata Duch) were investigated for industrial application. Methods : We were experimented radical scavenging effect, xanthine oxidase inhibition, tyrosinase inhibition and cytotoxicities effects of various cancer cell. Results : The results were obtained as follows Electron-donating ability(EDA) of the water extract of pumpkin was over 60% at concentration of 500 ppm, and ethanol extracts showed as high as 34% EDA. In both cell lines, water extract of pumpkin( Cucurbita moschata Duch) was higher than ethanol extract. Conclusion : The results indicated that water extract of pumpkin can be used as a natural ingredient with biological functions in cosmetic and food composition.
안봉전,이진태,곽재훈,박정미,이진영,박태순,손준호,최청 경산대학교 생명자원개발연구소 2003 생명자원과 산업 Vol.7 No.-
Biological activities and anticarcinogenicity of Korean Pear peel were investigated. Electron donating activity and superoxide dismutase(SOD)-like activity of fraction Ⅱ, Ⅲ were up to 90% and 50-60% at 50ppm, respectively. Inhibitory effects on xanthine oxidase were about 80% at 50ppm, breast adenocarcinoma was about 60% at 2,000 ppm, higher Ⅲ than Ⅱ. Inhibitory effect on prostate adenocarcinoma was about 23% at 500 ppm. In conclusion, Korean Pear peel was expected to use as a functional material.