http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
강삼식(Sam Sik Kang),김주선(Ju Sun Kim),곽의종(Wie-Jong Kwak),김기협(Ki-Hyup Kim) 한국생약학회 1990 생약학회지 Vol.21 No.2
Five biflavones and seven flavonol glycosides were isolated from the leaves of Ginkgo biloba. They were sciadopitysin(1), ginkgetin(2), isoginkgetin(3), bilobetin (4), amentoflavone(5), kaempferol 3-O-[6`-O-p-coumaroyl-β-D-glucopyranosyl(1→2)-α-L-rhamnopyranoside](6), quercetin 3-O-[6`-O-p-coumaroyl-β-D-glucopyranosyl(1→2)-α-L-rhamnopyranoside](8), rutinosides of kaempferol(7), isorhamnetin(9), quercetin (10), laricitrin(11), and kaempferol 3-O-(2, 6-α-L-dirhamnopyranosyl-β-D-glucopyranoside) (12). The structures were established by spectroscopic and chemical methods.
고속액체크로마토그라피에 의한 은행잎중 Flavonoid Glycoside 의 확인 및 정량
강삼식(Sam Sik Kang),김주선(Ju Sun Kim),곽의종(Wie Jong Kwak),김기협(Ki Hyup Kim) 한국생약학회 1990 생약학회지 Vol.21 No.2
Seven flavonol glycosides from the EtOAc fraction of Ginkgo biloba leaves were identified by high performance liquid chromatography. Separation by reversed phase chromatography on Lichrosorb RP-18 column was achieved by isocratic elution. The content of the major acylated flavonol glycoside, kaempferol 3-O-[6`-O-p-coumaroyl-β-D-glucosyl(1→2)-α-L-rhamnoside] was about 8.0% and 0.55% for EtOAc fraction and MeOH extract, respectively.
윤혜숙(Hye Sook Yun-Choi),유경숙(Kyung Sook Yoo),이숙연(Sook Youn Lee),이연희(Youn Hee Lee),곽의종(Wie Jong Kwak),김기협(Ki Hyup Kim) 한국생약학회 1990 생약학회지 Vol.21 No.4
Crude Aconiti Tubers were irradiated with microwave for 5 or 10 min with or without NaHCO₃. Ten min-irradiation reduced the contents of aconitine and mesaconitine to the level of those of commercially available processed Aconiti tuber power which is prepared with the high pressure-high temperature technique. The contents of benzoylaconine of the 10 min-irradiated Aconiti tubers were also comparable to those of commerciallized processed Aconiti tuber powder. However, irradiation with 1%o NaHCO₃ soln. resulted in the drastic reduction of all the three above alkaloids.
항염작용을 갖는 신규 생약복합제 SKI306X의 분리 및 항염작용
박광식(Kwang Sik Park),김환수(Hwan Su Kim),안재석(Jea Suk Ahn),김택수(Taek Soo Kim),박병욱(Pyeong Uk Park),곽의종(Wie Jong Kwak),한창균(Chang Kyun Han),조용백(Yong Baik Cho),김기협(Key H. Kim) 대한약학회 1995 약학회지 Vol.39 No.4
Antiinflammatory activities of the solvent fractionates of several herbal medicines were investigated and SKI306X was prepared from the active principles of three herbal medicines, Prunella vulgaris, Trichosanthes kirilowii and Clematis mandshurica. SKI306X was shown to have strong inhibitory effects on acetic acid-induced pain, carrageenan-induced paw edema and adjuvant-induced arthritis. LD50 of SKI306X was more than 5g/kg in rat, so generally nontoxic. Chemical analysis revealed that oleanolic acid and rutin, which are known to have various antiinflammatory activities, were contained in it. These results suggest SKI306X may become a useful drug for the treatment of inflammatory diseases such as rheumatoid arthritis.
Effect of Ginkgetin from Ginkgo biloba Leaves on Cyclooxygenases and In Vivo Skin Inflammation
Kwak, Wie-Jong,Han, Chang Kyun,Son, Kun Ho,Chang, Hyeun Wook,Kang, Sam Sik,Park, Byung Kyu,Kim, Hyun Pyo 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Ginkgetin, a biflavone from Ginkgo biloba leaves, was previously reported to be a phospholipase A_2 inhibitor and this compound showed the potent antiarthritic activity in art adjuvant-induced arthritis as well as analgesic activity. This investigation was carried out to find effects on cyclooxygenase (COX)-1 and -2 including an in vivo effect. Ginkgetin (1 - 10 ??M) and the biflavonoid mixture(10-50 ㎍/ml), mainly a 1:1 mixture of ginketin and isoginkgetin, from G. blloba leaves, inhibited production of prostaglandin E_2 from lipopolysaccharide-induced RAW 264.7 cetls. This inhibition was mediated, at least in part, by down-regulation of COX-2 expression, but not by direct inhibition of COX-1 or COX-2 activity. Down-regulation of COX-2 by ginkgetin was also proved in the dorsal skin of ICR mouse treated by 12-0-tetradecanoylphorbol 13-acetate (TPA). At total doses of 1,000㎍/site on the dorsal skin (15mm × 15 mm), ginkgetin inhibited prostaglandin E_2 production by 65.6% along with a marked suppression of COX-2 induction. in addition, ginkgetin and the biflavonoid mixture(100-1,000 ㎍/ear)dose-dependently inhibited skin inflammation of croton oil induced ear edema in mice by topical application. The present study suggests that ginkgetion from G.blloba leaves down-regulates COX-2 induction in vlvo and this down-regulating potential is associated with an anti-inflammatory activity against skin inflammatory responses.