성인 여성에서 비알코올성 지방간의 중증도에 따른 대사증후군 관련성

공은희 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background: The aim of this study was to elucidate the relationship between the grade of non-alcoholic fatty liver diseases diagnosed by ultrasonography and the metabolic syndrome defined by the Third Report of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) guideline. Methods: A total of 198 women who visited a health promotion center from January, 2007 to December, 2008 were selected for this study. The ultrasound scan of the liver was performed to determine the presence and the severity of non-alcoholic fatty liver disease. The relationship between non-alcoholic fatty liver and risk categories of metabolic syndrome using NCEP-ATP III guideline were analysed. Results: The prevalence of metabolic syndrome was 19.2% in women with non-alcoholic fatty livers. When odds ratios(95% CI) for metabolic syndrome in groups with moderate and severe non-alcoholic fatty livers were compared to that of group with mild non-alcoholic fatty livers, there was an increased risk of metabolic syndrome with an odds ratio of 2.24(1.31∼4.41). Conclusion: Non-alcoholic fatty liver disease was closely related to the metabolic syndrome in healthy women and the severity classification of non-alcoholic fatty liver by ultrasound scan could be useful to predict of the severity of insulin resistance and the risk of metabolic syndrome

美가 米를 죽인다

공은희 덕성여자대학교 1996 근맥 Vol.32 No.-

고혈압 환자와 정상인의 고혈압 인지도 비교

공은희,최종순 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

Background: Hypertension is one of the most important risk factors of cardiovascular disease and coronary artery disease. Awareness of hypertension is important in controlling of hypertension. We conducted a study on the awareness of hypertension comparing hypertensive patients with non-hypertensive patients. Methods: This study involved the number of hypertensive patients was 64, and that of non hypertensive patients was 53, who visited an outpatient of primary care practice, from November 1, to November 30, 2005. All subjects completed a questionnaire including demographic characteristics and awareness of hypertension. Results: No significant correlations were revealed between various characteristics and number of correct answers. The rate of correct answers to the questions concerning ‘frequency of blood pressure measurement' and 'treatment in asymptomatic patient' and 'life-long controlled disease' were higher in non-hypertensive patients than hypertensive patients. It was significant difference(p<0.05). The rate of correct answers to the questions concerning 'complication of hypertension' were higher in hypertensive patients than non-hypertensive patients. It was significant difference(p<0.05). All hypertensive patients correctly answered question concerning 'lifestyle modification' and 'regularly blood pressure check' and 'control of stress'. Conclusion: There was no significant difference of awareness regarding hypertension between these two groups. In order to correct wrong awareness of hypertension, We suggests the necessity of developing special program to achieve better compliance of hypertensive patients.

노인요양시설 간호제공자를 위한 웹기반 억제대 사용 감소 교육 프로그램 개발과 평가

공은희 노인간호학회 2012 노인간호학회지 Vol.14 No.3

일반 재가노인을 위한 치매교육 프로그램의 효과

공은희,정영순 지역사회간호학회 2011 지역사회간호학회지 Vol.22 No.3

Purpose: This study was conducted to evaluate the effects of a dementia education program for Korean older adults who resided in community. Methods: The research adopted the non-equivalent control group pretestposttest design. A total of 66 older adults completed the study (31 older adults in the experimental group and 35 in the control group). The Experimental group participated in a six-session dementia education program for three weeks. The effects of the dementia education program were evaluated using the measures of knowledge of dementia and attitude toward dementia. Data were analyzed using independent sample t-test with SPSS/WIN 18.0. Results: There was a significant change in the knowledge of dementia in the experimental group (t=2.75, p=.008). Although there was an increase in attitude toward dementia in the experimental group, the change was not statistically significant (t=1.26, p=.212). Conclusion: The results indicated that the dementia education program is effective in improving the knowledge of dementia among community-dwelling older adults. There is a need to develop more effective dementia education programs designed to improve older adults' attitude toward dementia. Further research is needed using a highly rigorous research methodology.

위암환자에서 GAGE 유전자의 발현과 임상적 의미

공은희,장희경 고신대학교(의대) 고신대학교 의과대학 학술지 2005 고신대학교 의과대학 학술지 Vol.20 No.1

Background : There is still little information on the function of GAGE gene in the stomach cancer except for cancer-specific gene expression recognized by autologous T lymphocytes. This study attempted to evaluate GAGE mRNA expression to elucidate its functional role in the carcinohistogenesis and clinical implication in gastric cancer. Materials and Method : Tumor and non-neoplastic paired samples from 60 patients with gastric cancer were studied by using reverse transcription - nested polymerase chain reaction (RT-PCR) with common primer. Results : No expression of GAGE was observed in non-neoplastic tissues. Fifteen out of 60 tumor tissues expressed GAGE (25.0%) mRNA, of which 13 cases (86.7%) were intestinal type and only 2 cases (13.3%) were diffuse type. GAGE expressions in cancer tissues have a significant tendency to be higher by stage and lymph node metastasis (p<0.05). However, they did not show significant relationship with tumor cell differentiation and vascular and perineural invasions. Conclusions : This results suggest that GAGE gene might have an important role in the development and progression of intestinal type of stomach cancer and GAGE gene may be a useful molecule for target of cancer-specific immunotherapy.

일개 내과 의원을 방문한 고혈압 환자의 고혈압 질환에 대한 인지도

공은희,최종순 고신대학교(의대) 고신대학교 의과대학 학술지 2006 고신대학교 의과대학 학술지 Vol.21 No.1

Background : Hypertension is one of the most important risk factors of cardiovascular disease and coronary artery disease. Awareness of hypertension by patients is important in controlling of the disease. 丁he purpose of this study was to compare awareness regarding hypertension by demographic and socio-economic status of the patients. Methods : This study involved 71 hypertensive patients who visited a physician’s out-patient clinic from November 1 to November 30,2005. All subjects were drawn up a questionnaire including demographic characteristics and awareness of hypertension, and compared by age, sex, education and economic status. Results : The correct rate to the questions concerning 'cause of hypertension* and 'protection of hypertension* were significantly higher in men(P<(乂05). The correct rate to the questions concerning 'blood pressure need to be once checked per day、 'anti-hypertensive medication should be taken for life* and 1 weight control is essential1 were significantly different by the age(P<0,05 乂 It was significantly different that the questions about * blood pressure check one per day、 ’cause of hypertension' ’symptom of hypertension \ * regular ant 卜 hypertensive medication、and ’modification of life style* were correctly answered by the high level of education(P<0乂)5), Conclusion : In order to correct wrong awareness of hypertension,the necessity of developing special program to achieve better compliance of hypertensive patients is mandatory. Background : Hypertension is one of the most important risk factors of cardiovascular disease and coronary artery disease. Awareness of hypertension by patients is important in controlling of the disease. 丁he purpose of this study was to compare awareness regarding hypertension by demographic and socio-economic status of the patients. Methods : This study involved 71 hypertensive patients who visited a physician’s out-patient clinic from November 1 to November 30,2005. All subjects were drawn up a questionnaire including demographic characteristics and awareness of hypertension, and compared by age, sex, education and economic status. Results : The correct rate to the questions concerning 'cause of hypertension* and 'protection of hypertension* were significantly higher in men(P<(乂05). The correct rate to the questions concerning 'blood pressure need to be once checked per day、 'anti-hypertensive medication should be taken for life* and 1 weight control is essential1 were significantly different by the age(P<0,05 乂 It was significantly different that the questions about * blood pressure check one per day、 ’cause of hypertension' ’symptom of hypertension \ * regular ant 卜 hypertensive medication、and ’modification of life style* were correctly answered by the high level of education(P<0乂)5), Conclusion : In order to correct wrong awareness of hypertension,the necessity of developing special program to achieve better compliance of hypertensive patients is mandatory.

Piplartine과 전립선암 세포사멸

공은희,김광연,유선녕,이선이,안순철 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Background: Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide.Piper species have known anti-proliferation and anti-cancer activity. This study was to examine the anti-proliferation effects of piplartine on human prostate cancer cell. Methods: PC-3 human prostate cancer cells received piplartine 15 uM for 24 hours. Microarray was performed on piplartine-treated PC-3 cells. Results: Among 253 genes which were altered by piplartine-treated PC-3 cells (>3-4 folds), 143 genes were up-regulated and 110 genes were down-regulated by piplartine in microarray. Most of genes whichwere up-regulated by piplartine were functionally classified as apoptosis, immune response related genes. Genes which were down-regulated by piplartine were functionally classified as transcription, cell cycle related genes. Conclusion: Piplartine may induce anti-tumor activity for human prostate cancer along with regulated of cell cycle and apoptotic genes in piplartine-induced PC-cells.

Low Bone Mass Related with Helicobacter pylori Infection in a Woman

공은희,이지영,주일우,김흥열,정민형,최훈 대한골다공증학회 2010 Osteoporosis and Sarcopenia Vol.8 No.1

A 39-year-old female had intermittent dyspepsia for 1 year. She was not a current smoker or an alcohol abuser. An upper gastrointestinal endoscopy showed erosive gastritis; the histologic diagnosis of the gastric mucosa was active gastritis with Helicobacter pylori infection. Dual-energy X-ray absorptiometry confirmed marked osteopenia at Wards’ region of the left femur; the bone mineral density was 0.605 g/cm2 and the Z-score was -1.8 (69%). The serum C-telopeptide was 0.259 ng/mL and the serum osteocalcin was 10.24 ng/mL. There were no significant muscle weakness, tenderness, or no joint abnormalities. It is required to consider as a secondary cause of osteopenia in patients with H. pylori infection in stomach and is essential to measure bone mineral density.

Effects of L-ascorbic acid on the production of pro-inflammatory and anti-inflammatory cytokines in C57BL/6 mouse splenocytes

공은희,마선영,정지영,김광혁 고신대학교(의대) 고신대학교 의과대학 학술지 2015 고신대학교 의과대학 학술지 Vol.30 No.1

Objective: The imbalance between pro-inflammatory and anti-inflammatory cytokines may underlie different pain states. Although ascorbic acid is the most important physiological antioxidant that affects host defense mechanisms and immune homeostasis, there is limited information on the effects of ascorbic acid on the production of cytokines. Methods: In this study, we investigated the in vitro effect of L-ascorbic acid (AA) on the production of pro-inflammatory and anti-inflammatory cytokines by stimulating C57BL/6 mouse splenocytes with the polyclonal activators lipopolysaccharide or concanavalin A. Results: AA significantly downregulated the expression of IL-6, IL-12, and TNF-α at 48 h and 72 h in mouse splenocytes treated with a combination of polyclonal activators and AA. AA treatment also resulted in upregulation of IL-4 and IL-10 at 72 h. These findings demonstrated that AA significantly potentiated production of anti-inflammatory cytokines whereas there was an inverse association between AA and expression of pro-inflammatory cytokines in mouse splenocytes. Conclusion: AA may have potential applications in the reduction of inflammatory pain because of its function in modulating the production of cytokines. However, further in vivo investigations are necessary to elucidate the mechanisms involved.