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33권6호 영문부록 : 흰쥐의 적출 심장에서 허헐처리후 Ketanine 의 양성 변력성 효과의 기전
고성훈(Seong Hoon Ko),김동찬(Dong Chan Kim),이상귀(Sang Kyi Lee),최훈(Hun Choe),송희선(He Sun Song) 대한마취과학회 1997 영문부록 Vol.- No.-
서 론: Ketamine은 여러 실험동물의 적출 심장에서 양성 변력성 작용을 보인다. 이러한 작용의 기전은 K+ 이온통로 억제에 의한 세포막 전위의 탈분극에 의해, 전압 민감성 Ca2+ 이온통로를 경유한 Ca2+ 이온의 세포내 증가로 여겨지고 있다. 본 연구에서는 K+ 이온통로의 일종으로 심장에서 허혈이나 저산소증시 활성화되는 ATP-민감성 K+ (ATP-sensitive K+, KATP) 이온통로와 심근허혈시 ketamine의 양성 변력성 작용의 상호 관계를 알아보고자 하였다. 방 법: 흰쥐 적출심장을 Langendorff 장치에 현수한 후 Krebs-Henseleit (KH)용액을 55 mmHg의 압력으로 관상동맥으로 관류시키면서 관류량을 측정하여 이때 관류량의 절반을 일정한 속도로 관류시켜 심근의 허혈을 유발하였다. 수축력의 측정은 좌심실의 압력 변화를 측정하였으며, 세포내 Ca2+ 농도의 변화는 단일 심실근 세포를 분리후 Ca2+과 결합하는 형광색소인 fura-2를 이용하여 측정하였다. 결 과: Ketamine은 수축력의 지표인 좌심실압을 용량 의존성으로 증가 시켰으며, 이는 propranolol (10-6 M)의 영향을 받지 않았다. 100 M의 ketamine은 좌심실압을 대조치에 비해 31.2 4.6% 증가 시켰으나, KATP 이온통로의 길항제인 glibenclamide (10-5 M) 존재하에서는 10.5 3.3%만을 증가 시켰다. 또한, K+ 이온통로 활성제인 pinacidil (3x10-5 M)은 좌심실압을 34.7 4.9% 감소시켰으나, ketamine 존재하에서는 단지 21.2 4.4%만을 감소시켰다. 고농도의 ketamine은 세포내 Ca2+ 농도를 증가시켰다. 결 론: Ketamine은 좌심실압과 세포내 Ca2+ 농도를 용량의존성으로 증가시켰다. 이러한 결과는 흰쥐의 적출심장에서 허혈시 ketamine이 양성 변력성 작용을 나타내며, 이는 KATP 이온통로의 억제가 부분적으로 관여함을 시사한다. (Korean J Anesthesiol 1997; 33: S1∼S8)
통증 자가 조절법을 이용한 상복부와 하복부 수술 후 통증의 비교
고성훈(Seong Hoon Ko),김동찬(Dong Chan Kim),이준례(Jun Rye Lee),한영진(Young Jin Han),최훈(Huhn Choi) 대한통증학회 2000 The Korean Journal of Pain Vol.13 No.2
N/A Background: We studied 250 patients who received intravenous patient-controlled analgesia (PCA) after lower and upper abdominal surgery to evaluate pain relief, analgesic consumption, patients mood and side effects. Methods: We made total 60 ml of analgesic mixture with morphine 60 mg, ketorolac 180 mg, droperidol 5 mg and normal saline. Loading and bolus dose and lockout interval were 0.05 ml/kg, 1.0 ml and 7 min, respectively. The duration of operation and the length of skin incision were recorded. Visual analog scale (VAS) pain and mood scores, cumulative analgesic consumption, and incidence of side effect were evaluated. Results: In the upper abdominal surgery group (Group 2), the duration of operation and length of skin incision were longer than Group 1. The average postoperative pain scores at 6, 24, and 48 hours in lower (Group 1) vs upper (Group 2) abdominal surgery were 4.3±2.1 vs 4.7±2.4, 3.3±1.9 vs 4.3±2.8, and 2.4±2.7 vs 3.2±2.1, respectively. There were no significant differences in the cumulative analgesic consumption and number of analgesic demands and at 6, 24, 48 hours after the operation between two groups. Group 2 patients required significantly longer pain control using PCA as compared to Group 1 patients. There were no significant differences in the incidence of side effects between the two groups. Conclusions: There was little difference in postoperative pain after lower and upper abdominal surgery.
임상연구 : 고농도 Desflurane 흡입에 의한 심혈관계 반응의 연령에 따른 차이
김은아 ( Eun Ah Kim ),김성규 ( Seong Kyu Kim ),임형선 ( Hyung Sun Lim ),고성훈 ( Seong Hoon Ko ),한영진 ( Young Jin Han ),송희선 ( He Sun Song ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.53 No.4
Background: The inhalation of high concentrations of desflurane transiently increases the cardiovascular responses. This study examined the effects of age on the cardiovascular response to desflurane. Methods: Eighty two patients were divided into one of three groups: under 3 years (Group 1), 20-50 years (Group 2), and over 65 years (Group 3). In each group, the inspired concentration of desflurane was increased abruptly to 12.0 vol% 2 minutes after a thiopental injection. The heart rate, blood pressure (BP), cardiac index (CI), End-tidal concentration of desflurane (ETdesf), and end-tidal concentration of CO2 were measured at the baseline and every 30 seconds. Results: The heart rate, BP, and CI increased transiently in the three groups compared with the baseline. The ETdesf increased more rapidly in Groups 1 and 3 than in Group 2. The ETdesf to reach the maximal mean arterial pressure (MAP) was highest in Group 3 among three groups. The relative maximal HR to the baseline value was similar in the three groups, but the relative maximal MAP to baseline value was significantly highest in the elderly patient group. The times to reach the maximal HR and BP were shortest in Group 1 among three groups. There were no significant differences in the CI between three groups. Conclusions: The inhalation of a high concentration of desflurane increases the HR, BP and CI transiently in all age groups. In pediatric patients, HR and BP increases more rapidly than in young adults and elderly patients. The relative maximal MAP to the baseline value is higher in elderly patients. (Korean J Anesthesiol 2007; 53: 435~40)
증례보고 : 전신마취하 제왕절개술 중 발생한 뇌실내 출혈
구희완 ( Hui Wan Koo ),손지선 ( Ji Seon Son ),한영진 ( Young Jin Han ),고성훈 ( Seong Hoon Ko ),송희선 ( He Sun Song ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.2
An intracranial hemorrhage is a fatal complication associated with general anesthesia. It can occur in patients with an intracranial aneurysm, hypertension, cerebral vascular malformation, and blood dyscrasia, etc. A sudden hemodynamic change during intubation and extubation in general anesthesia is dangerous, particularly in these patients. We encountered an intraventricular hemorrhage in a 42 year old pregnant woman after a cesarean section. The patient was induced with 300 mg of thiopental and 45 mg of rocuronium. The anesthesia was maintained with N2O/O2 and sevoflurane after endotracheal intubation. Five hours after surgery, the patient had a seizure at the ward. A MRI and CT scan of the brain showed a right intraventricular and basal ganglia hematoma. The CT 3-D brain angiography showed an unruptured small aneurysm on the right posterior communicating artery. (Korean J Anesthesiol 2006; 51: 257~60)
임상연구 : 전신마취 중 심전도의 교정 QT 간격에 대한 Ondansetron의 영향
김종익 ( Jong Ik Kim ),이상귀 ( Sang Kyi Lee ),손지선 ( Ji Seon Son ),고성훈 ( Seong Hoon Ko ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.53 No.6
Background: Prolongation of the corrected QT interval (QTc) has a potential risk of inducing life-threatening cardiac dysrhythmia. Although 5-HT3 antagonists are useful antiemetics, several cases of cardiac dysrhythmia after administration of 5-HT3 antagonists have been reported. Therefore, this study was conducted to evaluate the changes in QTc interval that occur after administration of a clinical dose of ondansetron during general anesthesia. Methods: Seventy-five patients, who underwent elective surgery under standardized general anesthesia were evaluated. After anesthetic induction, the patients were given either normal saline, 2 mg or 4 mg of iv ondansetron. The QTc on the electrocardiogram was measured immediately prior to administration of the treatment drug and then every minute after injection of the study drug for 10 minutes, 12 and 15 minutes. Results: There were no differences observed in the baseline QTc of the different treatment groups. In addition, there were no significant changes in the QTc interval of the control group, however, the QTc interval was prolonged significantly in both the ondansetron 2 mg and 4 mg groups. Further, ΔQTc (the difference in QTc interval from the baseline value) was significantly prolonged in the ondansetron 2 mg and 4 mg groups when compared with the control group. There were no differences in the number of patients who showed abnormal QTc and there were no incidences of dysrhythmia in any of the three groups. Conclusions: Ondansetron administration for emesis prophylaxis during general anesthesia was associated with statistically significant prolongation of the QTc interval. The authors recommend that caution be used when ondansetron is administered to prevent and/or treat postoperative nausea and vomiting, particularly in patients who have a prolonged QTc interval. (Korean J Anesthesiol 2007; 53: 704∼8)
임상연구 : 여성 호르몬과 생리 주기가 수술 후 통증에 미치는 영향
송하연 ( Ha Youn Song ),이정우 ( Jeong Woo Lee ),손지선 ( Ji Sun Son ),고성훈 ( Seong Hoon Ko ),한영진 ( Young Jin Han ),최훈 ( Huhn Choe ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.53 No.6
Background: This study was designed to examine the effects of female hormones and the menstrual cycle on postoperative pain. Methods: Ninety women who underwent gynecologic surgery involving a lower abdominal incision were asked for information regarding their menstrual cycles, and blood samples were obtained to determine the progesterone and estrogen levels of the patients at the time of surgery. Patient controlled analgesia was applied to control postoperative pain and an estimate of the consumption of analgesic drugs by the patients was made. Analgesic consumption and pain scores were recorded at 2, 24, and 48 hours after operation. Results: There was no relationship observed between the concentration of progesterone and estrogen and the consumption of analgesic drugs. However, patients that were in the luteal phase at the time of surgery consumed a significantly lower amount of analgesic drugs during the 2-24 hours following surgery than patients that were in the follicular phase (19.4 ± 6.5 ml vs 24.6 ± 11.0 ml, P < 0.05), Theree was, no significant difference in pain scores between two menstrual phases. Conclusions: This study demonstrates that there is less postoperative pain experienced by patients that are in the luteal phase of their menstrual cycle at the time of surgery than in patients that were in the follicular phase of their menstrual cycle, however, the results of this study did not reveal a relationship between the blood concentration of female hormones and postoperative pain. (Korean J Anesthesiol 2007; 53: 727∼32)