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최근 15년간 부산 및 동부 경남 지역 주요 피부 악성종양에 관한 임상적 및 통계적 고찰(1996∼2010)
하승민 ( Seung Min Ha ),고동엽 ( Dong Yeob Ko ),전수영 ( Su Young Jeon ),김기호 ( Ki Ho Kim ),송기훈 ( Ki Hoon Song ) 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.3
Background: The incidence of cutaneous malignant tumors, especially basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM), has continuously increased in Korea. However, there has been little research into the distribution and incidence of malignant skin tumors in the south-eastern part of Korea. Objective: The purpose of this study was to analyze recent trends in incidence and clinical patterns of cutaneous malignant tumors in Busan city and the eastern Gyeongnam Province. Methods: We reviewed 714 cases of cutaneous malignant tumors that include BCC, SCC, and MM from January 1996 to December 2010 at the Department of Dermatology in Dong-A University Hospital. Results: The average annual incidence of cutaneous malignant tumors among the total number of outpatients was 1.18% and has continuously increased from 0.63% to 1.91% over the last 15 years (1996∼2010). In particular, the average annual incidence of BCC and SCC has markedly increased from 0.35% and 0.25% to 0.94% and 0.79%, respectively. The most common cutaneous malignant tumor was BCC (48.32%), followed by SCC (41.18%) and MM (10.50%). The mean age of onset in patients who had been diagnosed with cutaneous malignant tumors was 65.07 years (males: 62.04, females: 67.87). There was a similar incidence between males and females in cutaneous malignant tumors (1:1.08). The most common site of cutaneous malignant tumors was the face (66.25%); the cheek (34.04%) was the most preferential site on the face, followed by the nose (30.23%). Conclusion: The incidence of cutaneous malignant tumors has gradually increased in Busan city and the eastern Gyeongnam Province, which was relatively higher than the incidence in other areas. It was thought to be due to the higher proportion of the elderly than in other areas of the country and skin cancer centers in our hospital. (Korean J Dermatol 2013;51(3):167∼172)
증례 헤르페스 포진형이 아닌 전신형 단순성 물집 표피박리증
고동엽 ( Dong Yeob Ko ),하승민 ( Seung Min Ha ),전수영 ( Su Young Jeon ),김대철 ( Dae Cheol Kim ),송기훈 ( Ki Hoon Song ),김기호 ( Ki Ho Kim ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.3
The other generalized type of epidermolysis bullosa simplex (EBS) is a genetic blistering skin disease, caused by a mutation of the genes encoding keratin 5 and 14. EBS starts at birth and is characterized by generalized blisters following a minor trauma that heals with hyperpigmentation. A 19-year-old man presented with 19-year history of multiple erythematous vesicles in a herpetiform arrangement on the trunk, axilla, and thigh with post-inflammatory hyper-pigmentations. On light and electron microscopy, the biopsy specimen showed intraepidermal blisters that formed within the basal keratinocyte. The serum from a patient with bullous pemphigoid antibody and laminin 5 antibody showed the linear deposition at the floor of the blister on immunofluorescence mapping study. On the basis of our clinical, microscopic, and immunofluorescence findings, we diagnosed the patient as having a generalized type of EBS. Herein, we report on an interesting case of the other generalized type of EBS. (Korean J Dermatol 2013;51(3):219∼222)
전립선암과 연관되어 발생한 것으로 보이는 Bullous Pemphigoid
고동엽 ( Dong Yeob Ko ),하승민 ( Seung Min Ha ),전수영 ( Su Young Jeon ),송기훈 ( Ki Hoon Song ),김기호 ( Ki Ho Kim ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.12
The presence of various cutaneous disorders may reflect the occult internal malignancy. Bullous pemphigoid (BP), a common autoimmune skin disease, is characterized by the presence of subepidermal blisters. The association of bullous pemphigoid with internal malignant neoplasm has occasionally been reported. However, the relationship of bullous pemphigoid and malignancy is still controversial; the evidence for this association is increasing. Here, we report a rare case of a bullous pemphigoid associated with prostate adenocarcinoma. (Korean J Dermatol 2012; 50(12):1069∼1072)
전수영 ( Su Young Jeon ),고동엽 ( Dong Yeob Ko ),홍진우 ( Jin Woo Hong ),이기열 ( Ki Yeol Lee ),김대철 ( Dae Cheol Kim ),송기훈 ( Ki Hoon Song ),김기호 ( Ki Ho Kim ),김영훈 ( Young Hun Kim ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.7
Syringoid eccrine carcinoma (SEC) is a rare adnexal tumor with some controversy surrounding its correct definition. It may also be difficult to differentiate from its benign counterpart (syringoma), other adnexal carcinomas, and cutaneous metastasis from adenocarcinomas. Histologically, the tumor is characterized by syringoma-like tadpole morphology composed of basaloid cells with ductular differentiation. However, the tumor cells are deeply invasive and often extend to subcutaneous tissue, which distinguishes this malignancy from syringoma. Moreover, the tumor cells may rarely show striking vacuolization due to intracytoplasmic glycogen accumulation, called clear cell syringoid eccrine carcinoma. To our knowledge, no case of clear cell SEC in Korea has ever been reported. Herein, we present a case of a SEC (of the clear cell variant) complemented with an immunohistochemical study, the latter revealing cytoplasmic accumulation of glycogen and the presence of intercellular and intracellular lumina in clear tumor cells, as well as diverse hallmarks of SEC.
Candida guilliermondii와 연관된 중심성 환상 홍반
전수영 ( Su Young Jeon ),고동엽 ( Dong Yeob Ko ),홍진우 ( Jin Woo Hong ),이채영 ( Chae Young Lee ),김기호 ( Ki Ho Kim ),송기훈 ( Ki Hoon Song ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.6
Erythema annulare centrifugum (EAC), first described by Darier in 1916, is characterized by annular, circinate, gyrate or serpiginous lesions. Although the pathogenesis of EAC is not fully understood, it is considered to be a hypersensitivity reaction to a wide variety of etiological factors, including autoimmune diseases, internal malignancies, drugs, infections, and pregnancy. To the best our knowledge, no case of EAC associated with Candida guilliermondii infection has ever been published in the Korean medical literature, and there have been a few reported cases associated with Candida albicans in other countries. Herein, we report on a rare and interesting case of EAC in a 62-year-old female patient with Candida guilliermondii infection.
위에 발생한 광범위 큰 B세포 림프종과 연관된 한랭글로불린혈증
전수영 ( Su Young Jeon ),고동엽 ( Dong Yeob Ko ),홍진우 ( Jin Woo Hong ),이기열 ( Ki Yeol Lee ),김기호 ( Ki Ho Kim ),송기훈 ( Ki Hoon Song ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.12
Cryoglobulinemia, first described by Wintrobe and Buell in 1933, is characterized by the presence of serum immunoglobulins that precipitate below 37oC and that dissolve on rewarming. Although the actual mechanism of cryoprecipitation and the etiology of cryoglobulinemia remains obscure, it is frequently associated with other systemic diseases, such as hepatitis C virus (HCV) infection, multiple myeloma, Sjogren`s syndrome, B cell lymphoma, and systemic lupus erythematosus. No cases of cryoglobulinemia associated with B cell lymphoma have ever been published in the Korean medical literature, and few such cases have been reported in other countries. Herein, we report on a rare and interesting case of cryoglobulinemia developed in a patient with gastric diffuse large B cell lymphoma. (Korean J Dermatol 2011;49(12):1087~1092)
Cyclospone의 NFATc1 발현 억제를 통한 모낭주기 조절(생장기모낭유도)에 대한 연구
이채영 ( Chae Young Lee ),고동엽 ( Dong Yeob Ko ),허은필 ( Eun Phil Heo ),김계정 ( Kea Jeong Kim ),송기훈 ( Ki Hoon Song ),김기호 ( Ki Ho Kim ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.11
Background: Hair growth is spontaneously activated from quiescent bulge stem cells or is activated from precocious anagen. Upon spontaneous activation of hair growth or activation induced by nuclear factor of activated T cells c1 (NFATc1) inhibitors, NFATc1 expression is lost and cyclin dependent kinase (CDK4) repression is relieved. Objective: The purpose of this study was to investigate the mechanisms of cyclosporine as a hair cycle regulator in the treatment of Alopecia areata (AA). Methods: In this study, we planned to investigate the hair growing properties of cyclosporine in vitro conditions. Briefly, the effects of different concentrations of cyclosporine (200, 500, 1,000, 2,000 mmol) on the growth of cultured hair follicles were examined through the expression of NFATc1 and CDK4. Results: NFATc1 was downregulated and CDK4 expression was upregulated especially in the bulge areas, outer root sheath and hair bulb matrix cells as the concentration of cyclosporine increased. Conclusion: Cyclosporine induces CDK4 expression by NFATc1 suppression, which acts to relieve repressed CDK4, resulting in hair growth. In conclusion, cyclosporine is one of the candidates as a therapeutic agent for the treatment of hair loss. (Korean J Dermatol 2013;51(11):871∼877)
전수영 ( Su Young Jeon ),하승민 ( Seung Min Ha ),고동엽 ( Dong Yeob Ko ),송기훈 ( Ki Hoon Song ),김기호 ( Ki Ho Kim ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.12
Atypical junctional melanocytic hyperplasia is a rare condition with unknown etiology. It is characterized by focal atypical melanocytic proliferation limited in the basal layer. Although this lesion is difficult to separate from melanoma in situ (MIS), it could be distinguished from MIS by the lack of several features, including lateral spread, upward epidermal migration, marked cytologic atypia, finely granular smoky melanin pigment, mitotic figures, and a subjacent host inflammatory response. In one study, atypical junctional melanocytic hyperplasia was found in 6.2% (25/400) of otherwise normal intradermal nevi. However, to our knowledge, no case of atypical junctional melanocytic hyperplasia with intradermal nevus has ever been published in Korean dermatologic literatures. Herein, we report a rare and interesting case of atypical junctional melanocytic hyperplasia with intradermal nevus. (Korean J Dermatol 2012;50(12):1077∼1080)