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별갑이 아토피 피부염에서의 알러지성 염증 반응에 미치는 영향
심태경 ( Tae Kyung Sim ),고대경 ( Dae Kyoung Ko ),김현창 ( Hyun Chang Kim ),백연종 ( Yeon Jong Baek ),이재석 ( Jae Seok Lee ),유화승 ( Hwa Seung Yoo ) 대전대학교 한의학연구소 2011 혜화의학회지 Vol.20 No.1
Objectives: This study aimed to investigate the effects of Amyda sinensis (AS) on allergic inflammation mechanism related atopy dermatitis. Methods: To investigate the effects of AS, We study inhibitory effect of AS on the levels of pro-inflammatory cytokines released from Raw264.7 cell stimulated with LPS (lipopolysaccaride), and EoL-1, THP-1, Jutkat cell stimulated with DP (Dermatophagoides pteronyssinus), and LPS indused acute inflammatory BALB/c mouse model. Result: AS reduced the levels of IL-1β released from Raw264.7 cell stimulated with LPS at 20 ug/ml, 5 ug/ml concentration, and reduced the levels of IL-6 in a dose-dependent. AS significantly reduced the levels of MCP-1 released from EoL-1 cell stimulated with DP (Dermatophagoides pteronyssinus) at all the concentration, and significantly reduced the level of IL-8 at 0.1 ug/ml concentration. AS significantly reduced the levels of MCP-1 released from THP-1 cell stimulated with DP (Dermatophagoides pteronyssinus) at 1 ug/ml concentration, and reduced the level of IL-6 in a dose-dependent. AS significantly reduced the levels of IL-4 released from Jutkat cell stimulated with DP at all the concentration, and significantly reduced the level of IL-5 at 0.1 ug/ml. 1 ug/ml concentration,. and reduced the level of TNF-α in a dose-dependent. AS significantly reduced the levels of TNF-α, IL-6, IL-1β, in LPS indused acute inflammatory BALB/c mouse model, in a dose-dependent. Conclusion: These result suggested that AS has suppressive effect on pro-inflammatory cytokines in various cell lines through the regulation of immune system. AS could be applied on the medicinal sources for treatment of immune abnormal diseases such as atopy dermatitis afterward.
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조남재(Namjae Cho),고대경(Dae-Kyung Ko),오승희(Seunghee Oh) 한국데이타베이스학회 2013 Journal of information technology applications & m Vol.20 No.4
Companies need to secure strong methods of new product development in a rapidly changing competitive environment. They overly focusing on the perception of consumers can not lead radical changes. They need to generate sufficient creative ideas in the early stages of new product development to make radical change. The purpose of this study is to examine the effect of a creative method on the generation of creative ideas. An enhanced creativity method was designed considering existing methodology and cognitive elements. This study specifically focused on team rather than individual level creativity. This arrangement reflects the fact that companies in practice rely on team unit in NPD process. The contribution of the study is two fold : enhancing existing methodology, and testing the effect of conceptual distance on making of creative ideas. The experimental results showed that appropriate conceptual distance help to make best creative output and that ABIS attribute is proved to be more effective than traditional association.
ScienceON
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