Synergistic Enhancement of Paclitaxel-Induced Inhibition of Cell Growth by Metformin in Melanoma Cells

고기현,김태형,고은정,박덕배,이영기 한국발생생물학회 2019 발생과 생식 Vol.23 No.2

Melanoma is one of the most aggressive and treatment-resistant malignancies. Antidiabetic drug metformin has been reported to inhibit cell proliferation and metastasis in many cancers, including melanoma. Metformin suppresses the mammalian target of rapamycin (mTOR) and our previous study showed that it also inhibits the activity of extracellular signal-regulated kinase (ERK). Paclitaxel is currently prescribed for treatment of melanoma. However, paclitaxel induced the activation of ERK/mitogen-activated protein kinase (MAPK) pathway, a cell signaling pathway implicated in cell survival and proliferation. Therefore, we reasoned that combined treatment of paclitaxel with metformin could be more effective in the suppression of cell proliferation than treatment of paclitaxel alone. Here, we investigated the combinatory effect of paclitaxel and metformin on the cell survival in SK-MEL-28 melanoma cell line. Our study shows that the combination of paclitaxel and metformin has synergistic effect on cell survival and suppresses the expression of proteins involved in cancer metastasis. These findings suggest that the combination of paclitaxel and metformin can be a possible therapeutic option for treatment of melanoma.

COVID-19 상황에서 대학운동선수들의 상해경험이 훈련참여동기 및 운동몰입에 미치는 영향

고기현 ( Gihyun Ko ),장덕진 ( Deokjin Jang ),이준희 ( Junhee Lee ),오채윤 ( Chaeyun Oh ) 중앙대학교 학교체육연구소 2022 Asian Journal of Physical Education of Sport Scien Vol.10 No.3

본 연구는 인구통계학적특성에 따른 상해심리, 훈련참여동기, 운동몰입을 분석하고, 상해심리와 훈련참여동기, 운동몰입에 어떠한 상관성과 영향력이 있는지 규명하는 데에 있다. 본 연구의 대상은 2021년 대한체육회의 소속되어있는 대학운동선수를 모집단으로 선정하여, 전국의 대학운동선수 266명을 비확률표본추출방법중 유의표집을 이용하여 선발하였다. 총336부의 설문지를 배부하여 307부의 설문지를 회수 하였으며, 회수가 된 설문지 중 불성실하게 응답을 하거나, 조사내용들 중 일부가 누락이 된 무성의한 자료 41부를 제외하여 최종 266명의 대상자의 자료가 실제 분석에 사용 되었다. 자료처리는 빈도분석, 타당도와 신뢰도 검증을 위한 요인분석, t-검정, 일원변량분산분석, 상관관계분석, 다중회귀분석을 이용하여 분석한 결과 다음과 같은 결과를 얻었다. 첫째, 인구통계학적 특성에 따른 상해심리, 훈련참여동기, 운동몰입에서는 학년, 운동종목, 상해시점, 코로나-19 이전 1일 훈련시간, 코로나-19 이후 훈련빈도에서 유의한 차이가 나타났다. 둘째, 대학운동선수의 상해심리가 훈련참여동기에 미치는 영향에서는 훈련참여동기의 내적동기에 운동 무기력 외적동기에 지도자 회피, 운동 무기력에 유의한 영향을 미치는 것으로 나타났다. 셋째, 대학운동선수의 상해심리가 운동몰입에 미치는 영향에서는 운동몰입의 인지몰입에 불안 및 걱정이 행위몰입에 불안 및 걱정이 유의한 영향을 미치는 것으로 나타났다. 넷째, 대학운동선수의 훈련참여동기가 운동몰입에 미치는 영향에서는 운동몰입의 인지몰입과 행위몰입에 외적동기가 유의한 영향을 미치는 것으로 나타났다. 이상의 결과를 종합해보면 대학운동선수의 상해심리가 훈련참여동기 및 운동몰입에 유의한 영향을 미치는 것으로 나타났다. The purpose of this study is to analyze injury-related psychological factors, participation motivation, and exercise commitment according to demographic characteristics to examine the association between those variables on the effects of injury occurrence. The participants were selected collegiate athletes registered in 2021 Korea Sports Council and 266 college athletes nationwide were participated in this study using purposive sampling among nonprobability sampling methods. A total of 336 surveys were distributed and 307 surveys were retrieved. The final 266 participants were used for the actual analysis with the exclusion of 41 copies without any injury experience. For data processing, the following results were obtained as a result of analysis using frequency analysis, validity and reliability, factor analysis for verification, Mann-Whitney Tests, t-test, one-way ANOVA, correlation analysis, and multiple regression analysis. First, there were significant differences in grade, sports event, time of injury, training time om injury psychology, training participation motivation, and exercise immersion. Second, it was found that it had significant effects on the intrinsic motivation of training participation, exercise lethargy, extrinsic motivation, and differences on leadership avoidance and exercise lethargy. Third, it was found that anxiety and worry had a significant effect on cognitive immersion on behavior immersion. Fourth, it was found that extrinsic motivation had significant effects on cognitive and behavioral commitment of exercise commitment. Combining the above results, it was found that the injury-related psychology of collegiate athletes had significant effects on training participation motivation and exercise commitment.

농식품 분야의 공동창업을 통한 공유가치창출(CSV) 사례연구

이동민,고기현,박성희,이현,문정훈,Lee, Dong Min,Ko, Ki Hyeon,Park, Sung Hee,Lee, Hyun,Moon, Jung Hoon 한국벤처창업학회 2013 벤처창업연구 Vol.8 No.2

기존의 기업의 사회적 책임(CSR, Corporate Social Responsibility)의 전략적인 발전 형태인 Porter(2011)의 공유가치창출(CSV, Creating Shared Value)은 기업의 핵심역량을 발휘하여 기업적 가치를 창출하는 동시에 사회 내의 다른 이해관계자들의 사회적 가치를 창출한다는 점에서 자본주의적 원칙에 더욱 부합하는 형태라 할 수 있다. 본 연구에서는 CSV 개념을 기업 경영에 도입하여 가치를 창출하는 식품기업 사례를 살펴본다. 식품산업의 특성을 고려하여 농촌 농업에 대한 CSV 활동에 초점을 맞추어 사례분석을 실시하였다. 사례분석 결과 사회적 가치와 기업적 가치의 접점에서 새로운 조직이 구성되는 '공동창업형' CSV 활동이 발견되었다. 기업이 농업 농촌의 이해관계자들과 협업하여 새로운 조직을 창업하는 양상은 공유가치 창출 방법에 따라 다소 차이를 보이지만, 기업과 이해관계자의 가치창출을 동시에 추구한다는 점에서 공통점이 발견된다. 본 사례연구는 CSV 기반 창업활동을 제시하여 동반성장, 상생경영에 대한 시사점을 도출하였다는 점에서 의의를 갖는다. Porter(2011)'s CSV(Creating Shared Value) is a more strategically advanced perspective of CSR(Corporate Social Responsibility). CSV creates corporates' value by exploiting the firms' own core competence and social value of the stakeholders in the community such firms simultaneously belong to. In this points of view, CSV is more appropriate for the principles of capitalism than CSR. A case study on food producing firms that adopted the concept of CSV to their business management was conducted. Considering the characteristics of food industry, the researchers have investigate many existing cases, especially focused on the CSV activities toward rural area and agriculture. As result of the case analysis, the 'mutual firm-establishing-CSV,' which refers to the new organization established on the point of contact where corporate value and social value meet, was observed. The aspects of establishing a new organization by firms' collaborating with rural area and agriculture is different in accordance with each firm's method of creating shared value. However, the cases have common grounds that the created value is for pursuing both firms' and stakeholders' value. This study is significant, in that the study deducts implications about accompanied growth and win-win management by suggesting the establishment of firms based on CSV.

Success Factors of Paris Baguette’s Bakery Franchise Business: Industry Competition and Core Competence Analysis

정재석,정한나라,고기현,문정훈,강형구 한국마케팅학회 2013 ASIA MARKETING JOURNAL Vol.15 No.2

The main goal of this study is to examine the competition intensity in the Korean bakery franchise industry and to identify the core competencies of the industry’s leading company, Paris Baguette. The frameworks of PEST analysis, Cross Impact analysis, a Five Forces Model, a Value Chain, and VRIO analysis. PEST and Cross Impact analysis were employed to investigate the industry’s external environment, and the results indicated that ‘increased attention on corporate’s Creating Shared Value (CSV) activities’ is the most influential factor among others. The analysis using the Five Forces Model found industry rivalry and substitutes were the greatest threats. Finally, the results of Value Chain and VRIO analysis identified four core competencies of Paris Baguette: its CEO’s craftsmanship, e-procurement system, quality of dormant dough, and hub system. Multiple managerial implications are suggested for practitioners in the marketing area, especially in the saturated market environment.

대학교 도서관에 위치한 열람실의 사용자 만족도 조사 및 개선사항 도출

서은지(Eunji Seo),고기현(Gihyun Go),복제욱(Jewook Bok),박지영(Jiyoung Park) 한국색채학회 2020 한국색채학회 학술대회 Vol.2020 No.11

선행연구의 분석 결과, 학습을 위한 공간에서 조도가 너무 낮거나 높으면 독서 및 학습활동, 자료 이용 등에 불편을 느끼게 되는 것으로 분석되며, 보조조명의 병용을 권장하고 있는 것으로 분석되었다. 또, 자료의 내용적 분석과 이해를 위한 인지력, 사고력, 판단력, 집중력 등이 저하됨으로써 기회비용이 증가하는 등 비효율적이 되며, 두통, 피로도 등의 신체적 고통이 증가하는 것으로 나타났다. 이에 본 연구에서는 대학교 도서관에 위치한 공공열람실의 실내 색채 및 조명환경에 대한 사용자의 만족도 조사를 진행하고, 개선사항 도출을 목적으로 한다. 또한 도출된 개선사항을 열람실의 환경 구성에 반영할 경우 학습효과에 긍정적인 영향을 미칠 것으로 사료된다.

외식 프랜차이즈의 광고 모델 특성이 모델 만족도, 브랜드 이미지 그리고 구매 의도에 미치는 영향

송혜선(Hae-Sun SONG),고기현(Ki-Hyun KO) 한국프랜차이즈경영학회 2021 프랜차이즈경영연구 Vol.12 No.4

Purpose: Marketing communication with customers is essential for companies to survive and grow in a fiercely competitive environment. Advertising is one of the most readily accepted marketing communications by consumers. Unlike a company that owns a distribution network, advertising is vital for a franchise. In general, many advertising models select celebrities. Celebrities are more likely to attract audience attention and influence consumers purchase intentions. Customers satisfied with advertising are more likely to stay loyal and buy again when the company launches a new product. In addition, customers form a brand image through advertisements. Therefore, in this study, the effect of the characteristics of the foodservice franchise advertising model characteristics on model satisfaction, brand image, and purchase intention. Research design, data, and methodology: The survey of this study was conducted among consumers over the age of 20 who had seen a restaurant franchise advertisement and visited a store within the last 2 months. 305 copies were collected for 7 days during the survey period, from October 21 to October 27, 2021. Among the collected questionnaires, 12 insincere questionnaires were excluded, and 293 were used for analysis. SPSS 25.0 and Smart PLS 3.0 were used as data collected to test the hypothesis. Result: As a result of the study, among the advertising model characteristics of a foodservice franchise, reliability, attractiveness, expertise, and closeness all had a significant positive (+) effect on model satisfaction. In addition, reliability and closeness were found to have a significantly positive (+) effect on brand satisfaction, but attractive and expertise did not significantly affect brand image. Finally, model satisfaction was found to have a significant positive (+) effect on brand image and purchase intention. Brand image also appeared to have a significant positive effect on purchase intention. Conclusions: Research Results First, this study verified the effect of a restaurant franchise advertising model using celebrities by using the characteristics of the advertising model. Second, this study developed a conceptual structure for model characteristics - model satisfaction - brand image - purchase intention. Third, the restaurant franchise marketer needs to select a model in consideration of the privacy of the advertising model. Fourth, consumers tend to equate advertising models with advertising Keywords : Franchise’s Advertising, Model characteristic, Satisfaction, Brand image, Purchase