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한국에서의 호산구성 농포성 모낭염의 임상 및 병리조직학적 연구
장경애(Kyoung Ae Jang),고광진(Gwang Jin Koh),김성범(Sung Bum Kim),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.10
Background:Eosinophilic pustular folliculitis (EPF) is a rare chronic disease of unknown cause with pruritic papulopustular lesions and a prominent eosinophilic infiltrate. Objective:The purpose of this study was aimed at evaluating the clinical and histopathological features of EPF.Methods:The hospital charts and histopathologic slides of 8 patients with EPF diagnosed at Asan Medical Center from 1989 to 1998 were reviewed. We also reviewed the previously published reports of 10 patients with EPF in Korea. Results:Nine male and nine female patients were enrolled in this study. The mean age at diagnosis of EPF was 26 years in men and 27 years in women. All the patients complained of mild to severe pruritus. EPF was presented with follicular papules or pustules, except 2 patients, who presented with erythematous plaques free of papules or pustules. All the patients showed the typical histopathological findings of EPF. Laboratory investigation showed hypereosinophilia in 73% of patients (11/15). The levels of blood eosinophils tended to decrease as cutaneous lesions resolved. EPF was improved with dapsone in 12 patients and the rest were treated with topical or systemic steroid or antihistamines.Conclusion:EPF may be more common in Korea than can be suspected. Because EPF showed characteristic histopathological findings and EPF responds well to dapsone, the knowledge with this disease may be important to diagnose and treat it. (Korean J Dermatol 2000;38(10):1287~1293)
김경진,장성은,문기찬,성경제,최지호,고재경,고광진 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.12
Primary cutaneous diffuse large B-cell lymphomas are characterized by a non-epidermotropic monotonous infiltrate of large follicular center cells with various proportions of centroblasts, large centrocytes, multilobated cells or immunoblasts without extracutaneous manifestations. We report a case of a 61-year-old man, who presented with several, annular plaques on the trunk. The clinicopathologic features and immunohistochemical profiles were diagnostic of primary cutaneous diffuse large B-cell lymphoma.