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고경혁,양정욱,송대현,김동희 대한병리학회 2008 Journal of Pathology and Translational Medicine Vol.42 No.4
A well-differentiated extraskeletal osteosarcoma is very rare, and only seven cases have been reported in the English language clinical literature. We report an additional case of this rare tumor. A 71-year-old man had noticed a mass in the left pubic area for ten years. A CT scan demonstrated the presence of a lobulated calcified mass within the soft tissue. A 5 cm-sized well-circumscribed mass was excised. Histologically the tumor was composed of mature collagenous tissue and bony trabeculae rimmed by osteoblasts. After 43 months, the tumor recurred at the same site and was re-excised. The re-excised tumor contained focal areas of higher cellularity and atypism. We believe that this is the first case of well-differentiated extraskeletal osteosarcoma reported in Korea.
고경혁 한국간담췌외과학회 2000 한국간담췌외과학회지 Vol.4 No.1
Cystic hepatocellular carcinoma is unusal, and visualization of the cystic components within hepatic mass lesion have suggested that the lesions were metastatic tumors, primary cystic tumors such as biliary cystadenocarcinoma or cystic papillary cholangiocarcinoma. Although hepatic lesions can be well characterized by noninvasive imaging modalities, findings are often nonspecific. Even for cystic hepatic lesions a considerable diagnostic differential exists. The diagnosis of cystic hepatocellular carcinoma was difficult before the microscopic examination of the biopsy speciemen because of very rare. Then we report an unusual of cystic hepatocellular carcinoma without liver cirrhosis. Cystic hepatocellular carcinoma is unusal, and visualization of the cystic components within hepatic mass lesion have suggested that the lesions were metastatic tumors, primary cystic tumors such as biliary cystadenocarcinoma or cystic papillary cholangiocarcinoma. Although hepatic lesions can be well characterized by noninvasive imaging modalities, findings are often nonspecific. Even for cystic hepatic lesions a considerable diagnostic differential exists. The diagnosis of cystic hepatocellular carcinoma was difficult before the microscopic examination of the biopsy speciemen because of very rare. Then we report an unusual of cystic hepatocellular carcinoma without liver cirrhosis.
Vidas Chlamydia 검사와 직접도말표본을 이용한 Chlamydia trachomatis 항원 검출
김선주,김종화,김윤정,고경혁 대한감염학회 1998 감염 Vol.30 No.5
목적: Chlamidia trachomatis 감염은 성인성 전파 질환의 흔한 원인균이며 불임, 자궁외 임신 등의 심각한 합병증을 유발하기 때문에 신속한 진단 및 치료가 필수적이다. 효소 면역법 및 직접도말표본검사를 이용하여 질염환자에서 C. trachomatis 검출율을 비교하여 두 검사의 유용성을 살펴보고자 하였다. 방법: 1995년 1월부터 1996년 2월까지 경상대학교병원 산부인과에 내원하였던 환자중 염증소견이 있는 78명을 대상으로 Vidas Chlamydia (bioMerieux Vitek, Inc., Hazelowood, Mo.)를 이용한 C. trachomatis 항원 검사와 질 도말표본 검사를 시행하여 다음과 같은 결과를 얻었다. 결과: Vidas Chlamydia 검사는 총 78예 중 5예 (6.4%)에서 양성이었고, 이중 임산부는 13예에서 1예(7.7%)가 양성이었다. 양성 환자의 주증상은 질분비물과 소양증이었다. 질도말표본에서는 총 78예 중 1예에서 C. trachomatis의 reticulate body를 관찰할 수 있었고, 질도말표본 양성인 1예는 Vidas Chlamydia 검사에서도 양성이었다. 결론: Vidas Chlamydia 검사는 효소면역형광법을 이용하여 객관적인 검사를 할 수 있으며 많은 양의 검체를 동시에 시행할 수 있어 특히 검사 건수가 많은 양의 검체를 동시에 시행할 수 있어 특히 검사 건수가 많은 병원에서 C. trachomatis의 진단 및 치료에 유용하게 이용할 수 있을 것으로 사료된다. 한편, 질 도말표본 염색에서 chlamydia를 증명하는 세포학적 방법은 노력에 비해 효과적이지 못한 것으로 생각된다. Background: Because Chlamydia trachomatis infection is the most frequent etiological agent in sexually transmitted diseases, accurate diagnostic methods are essential. The enzyme-linked fluorescence assay and Papanicolaou smear were evaluated for detection of C. trachomatis in patients with vaginitis. Methods: Endocervical swabs from 78 women with symptoms of vaginal discharge, itching or lower abdominal pain in the obsterics/gynecology department of Gyeongsang National University Hospital were tested by Vidas Chlamydia assay. Slides were stained with Papanicolaou and Giemsa stain to demonstrate inclusion body. Results: Five (6.4%) of 78 endocervical specimens were positive by Vidas Chlamydia assay. Only one case was positive for C. trachomatic with Papanicolaou stain. We could not detect any C. trachomatis by Giemsa stain. Conclusion: The Vidas Chlamydia test allows sensitive and high-volume testing for chlamydiae and could be useful for the diagnosis of infection with C. trachomatis in patients with vaginitis and pelvic inflammatory disease.
박철근,고경혁 慶尙大學校 1988 論文集 Vol.27 No.1
1984년 1월부터 1987년 7월까지 경상대학교 의과대학 병리학교실에서 진단한 55예의 유방이형성증을 병리학적으로 재검색하여 다음의 결과를 얻었다. 1. 유방이성형증의 평균 발생연령은 35·6세이었다. 2. 유방이성형증에 속하는 각 병변들 중 선증이 가장 많았고 이어서 섬유증, 상피세포증생, 섬유선종증, 아포크라인화생, 미세낭종의 순이었으며, 거대낭종은 관찰되지 않았다. 3. 미세낭종은 선증에서 생기는 것으로 생각되며, 여기에는 아포크리인화생이 관여할 것으로 생각된다. 4. 섬유선종증과 순수한 섬유증은 유방이성형증에서 제외되어야 할 것으로 생각된다. The following results were obtained from the pathological study of 55 cases of mammary dysplasia. 1. The average age of patients of mammary dysplasia was 35.6 years. 2. Adenosis was the most frequent component of mammary dysplasia, followed by fibrosis, epithelial hyperplsia, fibroadenomatosis, apocrine metaplasia and microcyst. Gross cysts were not observed. 3. Adenosis appeared to be a precursor to microcyst formation, and the process seemed to be influenced by apocrine metaplasia. 4. Fibroadenomatosis and pure primary fibrosis were thought to be excluded from mammary dysplasia.