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고경남,유건희,임호준,성기웅,구홍회,김효선,한정우,윤종형,박현진,박병규,백희조,국훈,이준안,이재민,이광철,김순기,박미림,이영호,유철주,서종진 대한의학회 2016 Journal of Korean medical science Vol.31 No.8
This retrospective study investigated the clinical characteristics and outcomes of second malignant neoplasms (SMNs) in survivors of childhood cancer from multiple institutions in Korea. A total of 102 patients from 11 institutions who developed SMN after childhood cancer treatment between 1998 and 2011 were retrospectively enrolled. The most common primary malignant neoplasms (PMNs) were central nervous system (CNS) tumors (n = 17), followed by acute lymphoblastic leukemia (n = 16), non-Hodgkin lymphoma (n = 13), and osteosarcoma (n = 12). The most common SMNs were therapy-related myeloid neoplasms (t-MNs; acute myeloid leukemia [AML], 29 cases; myelodysplastic syndrome [MDS], 12 cases), followed by thyroid carcinomas (n = 15) and CNS tumors (n = 10). The median latency period was 4.9 years (range, 0.5-18.5 years). Among 45 patients with solid tumors defined as an SMN, 15 (33%) developed the lesion in a field previously subjected to radiation. The 5-year overall survival (OS) rate of patients with an SMN was 45% with a median follow-up time of 8.6 years. Patients with AML, MDS, and CNS tumors exhibited the poorest outcomes with 5-year OS rates of 18%, 33%, and 32%, respectively, whereas those with second osteosarcoma showed comparable outcomes (64%) to patients with primary counterpart and those with second thyroid carcinoma had a 100% OS rate. Further therapeutic efforts are recommended to improve the survival outcomes in patients with SMNs, especially in cases with t-MNs and CNS tumors.
고경남,임호준,김혜리,강형진,박경덕,신희영,안요셉,이지원,유건희,성기웅,구홍회,임영탁,박준은,박병규,박현진,서종진 대한의학회 2017 Journal of Korean medical science Vol.32 No.4
This multicenter, prospective trial was conducted to develop an effective and safe reinduction regimen for marrow-relapsed pediatric acute lymphoblastic leukemia (ALL) by modifying the dose of idarubicin. Between 2006 and 2009, the trial accrued 44 patients, 1 to 21 years old with first marrow-relapsed ALL. The reinduction regimen comprised prednisolone, vincristine, L-asparaginase, and idarubicin (10 mg/m2/week). The idarubicin dose was adjusted according to the degree of myelosuppression. The second complete remission (CR2) rate was 72.7%, obtained by 54.2% of patients with early relapse < 24 months after initial diagnosis and 95.0% of those with late relapse (P = 0.002). Five patients entered remission with extended treatment, resulting in a final CR2 rate of 84.1%. The CR2 rate was not significantly different according to the idarubicin dose. The induction death rate was 2.3% (1/44). The 5-year event-free and overall survival rates were 22.2% ± 6.4% and 27.3% ± 6.7% for all patients, 4.2% ± 4.1% and 8.3% ± 5.6% for early relapsers, and 43.8% ± 11.4% and 50.0% ± 11.2% for late relapsers, respectively. Early relapse and slow response to reinduction chemotherapy were predictors of poor outcomes. In conclusion, a modified dose of idarubicin was effectively incorporated into the reinduction regimen for late marrow-relapsed ALL with a low toxic death rate. However, the CR2 rate for early relapsers was suboptimal, and the second remission was not durable in most patients.
고경남,허종철 濟州大學校 産業技術硏究所 1997 산업기술연구소논문집 Vol.8 No.2
This experimental study has been conducted to investigate spray mechanism of diesel spray under the parameters of injection pressure and ambient pressure. Also this study provides the information on effect of sac chamber. The results obtained in this study are as follows : The higher ambient pressure. the shorter length ofthe ligaments and atomization is happened droplet from ligament rapidly. The fuel which remain in sac chamber and orifice becomes projected liquid column of spray tip at initial stage. this is atomized by overtaking of spray tip for time elapsed.
Year-to-year variation in wind resource and assessment of WAsP prediction for wind machine power
고경남,강문종,허종철 대한기계학회 2009 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.23 No.3
An investigation on inter-annual variations in wind resource and the accuracy of WAsP prediction was carried out in a real wind farm located at Hangwon, Jeju island, Korea. The wind data were obtained from an anemometer, and the wind vane installed on the meteorological mast and the operational data of the wind turbines tested were given by a monitoring system. The data were obtained for each six-month period in 2005 and 2006, respectively. As a result, it is clear that the wind characteristics vary year by year. Also, it was found that the cup anemometer on the meteorological mast in Hangwon wind farm was affected by the wake behind wind turbines. Considering the wake effect, the accuracy of WAsP prediction for the power production was assessed. The result shows that the relative error for the corrected power production that considered the wake loss was less than ±10 %.