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고가연(Ga Yeon Ko),박선정(Sun Jung Park),배소현(So Hyun Bae) 한국간호연구학회 2022 한국간호연구학회지 Vol.6 No.2
Purpose : To help nursing students understand flight nursing by checking the level of awareness of nursing students about flight nurses, and to provide data that is the basis for future nursing education program development. Method : This study is a descriptive research study, and data were collected from April 4 to April 10, 2022 from 214 students from the first to fourth grades of nursing department in Seoul and Gangwon. Results : As a result of analyzing the meaning of nursing students by applying the content analysis method, a total of 5 areas, 20 categories, and 99 meaningful statements were derived. Conclusion : The results of this study will be helpful in understanding the degree of awareness of flight nurses perceived by nursing students, and will serve as basic data for developing and expanding nursing students’ training programs for flight nurses and enhancing the effectiveness of education.
고가연,최지현,박상용,배소현 한국간호연구학회 2023 한국간호연구학회지 Vol.7 No.4
Purpose : This study aimed to provide foundational insights into various issues related to work-life balance by analyzing interview data on how nurses perceive this concept. Methods : Conducted as a descriptive exploratory research, data were collected from 80 nurses in Seoul and Gyeonggi Province from August 1 to September 20, 2023. Results : Applying content analysis, the study identified four domains, twelve categories, and twenty-two meaningful statements, shedding light on nurses' perceptions of work-life balance. Conclusion : This research contributes to understanding nurses' awareness of work-life balance and can serve as foundational data for improving hospital organizational culture to enhance nurses' work-life balance.
Perovskite-Quantum-Dots/Graphene을 이용한 광검출 소자 개발
이기정,고가현,김진형,김정길 한국물리학회 2022 새물리 Vol.72 No.12
Low-dimensional materials have attracted considerable attraction due to their high potential in applications in optoelectronic devices given their unique physical properties. In this study, a thin-film photodetector was developed using graphene with a high electrical conductivity and perovskite quantum dots with a charge-trapping property. The transparent and flexible graphene was transferred onto a silicon oxide. Metal electrodes were fabricated at both ends, and perovskite quantum dots were coated between them. The I−V curve characteristics were observed by measuring the current while changing voltage in dark and light conditions. The photocurrent was confirmed after observing the higher current in the light condition than in the dark condition. In the case of irradiating laser pulse, the current as a function of time was also measured. When laser was applied, the current rapidly increased, and when the laser was turned off, the current decreased slowly by more than several thousands of seconds. 저차원 물질은 독특한 전기적, 광학적 특성으로 다양한 광전소자에 높은 응용 가능성을 보인다. 본 연구에서는 높은 전기전도도를 갖는 그래핀과 많은 전하를 저장할 수 있는 페로브스카이트 양자점을 이용하여 광검출기를 개발하였다. 우선 투명하고 유연한 대면적 그래핀을 산화실리콘 기판위에 습식 전사를 한다. 그 다음으로 금속 전극을 양 끝에 제작하고 그 사이에 페로브스카이트 양자점을 코팅하였다. 암상태와 광상태에서 제작한 소자의 그래핀에 전압을 변화하며 전류를 측정하여 I−V 곡선 특성을 관찰하였다. 제작한 소자에 빛을 조사한 경우의 전류가 암상태의 전류보다 높음을 관찰함으로 광전류 특성을 확인하였다. 빛을 조사한 경우 시간에 대한 전류변화도 측정하였다. 레이저를 인가하면 빠르게 전류가 증가하고, 레이저를 끄면 매우 천천히 수천 초 이상의 시간동안 전류가 천천히 감소하였다. 이러한 특성을 이용하면 향후 페로브스카이트 양자점/그래핀 광검출기를 광전 메모리 소자로도 응용이 가능할 것이다.
Metabolic reprogramming as a novel therapeutic target for Coxsackievirus B3
국명욱,가윤지,김예진,박지윤,송은선,이하늘,이윤행,고가현,김재광,예정용,권형욱,변영주,박준태 한국통합생물학회 2022 Animal cells and systems Vol.26 No.6
Coxsackievirus B3 (CVB3) is a single-stranded RNA virus that belongs to the Enterovirus genus. CVB3 is a human pathogen associated with serious conditions such as myocarditis, dilated cardiomyopathy, and pancreatitis. However, there are no therapeutic interventions to treat CVB3 infections. In this study, we found that CVB3 induced metabolic alteration in host cells through increasing glycolysis level, as indicated by an increase in the extracellular acidification rate (ECAR). CVB3-mediated metabolic alteration was confirmed by metabolite change analysis using gas chromatography-mass spectrometry (GC-MS). Based on findings, a strategy to inhibit glycolysis has been proposed to treat CVB3 infection. Indeed, glycolysis inhibitors (2-Deoxy-Dglucose, sodium oxide) significantly reduced CVB3 titers after CVB3 infection, indicating that glycolysis inhibitors can be used as effective antiviral agents. Taken together, our results reveal a novel mechanism by which CVB3 infection is controlled by regulation of host cell metabolism.
Improvement of Tol2 Transposon System by Modification of Tol2 Transposase
박지윤,이하늘,송은선,이윤행,국명욱,고가현,변영주,권형욱,박준태 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.6
Tol2 transposon-based vector platform has been developed as a useful strategy to improve protein yield. Tol2 transposase identifies inverted terminal repeats of transposons and enhances transgene integration efficiency in the genome. However, Tol2 transposon system does not reach a level of efficiency for use in commercial production, limiting its usefulness for mass production of recombinant proteins. Here, we proposed a novel strategy to improve the existing Tol2 transposase by adding a nuclear localization signal of histone H2B next to the Tol2 transposase (i.e., NLS-H2B-Tol2 transposase). Comparing the NLS-H2BTol2 transposase with the traditional Tol2 transposase, a significant increase in protein production was measured. Concurrently, a significant increase in nuclear transport of NLS-H2B-Tol2 transposase was observed, suggesting a causal relationship between increased nuclear transport and increased protein production. Furthermore, importin beta maximized NLS-H2B-Tol2-mediated protein productivity. Taken together, our findings offer useful ways for improving conventional Tol2 transposon-based vector platform. This new platform will be a breakthrough in the field of biopharmaceuticals to produce therapeutic proteins.