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운동생리학 : 저산소증이 골격근 혈관 내피 세포 성장 인자의 발현에 미치는 영향
김재철(JaeCheolKim),하경수(KyoungSuHa),윤정수(ChungSuYoon),강희성(HeeSeoungKang),김창근(ChangKeunKim) 한국체육학회 2005 한국체육학회지 Vol.44 No.1
Low oxygen(O2) is the key stimulus for expression of vascular endothelial growth factor in skeletal muscle. The aim of this study was to investigate the expression of VEGF mRNA and proteins in skeletal muscle by hypoxia. Male Sprague-Dawley rats were exposed to hypoxia condition(8% O2) for 1, 2, 3, 6, and 12hours. The VEGF mRNA and protein in gastrocnemius and soleus muscles were examined by Northern blotting and Wester blotting.Expression of VEGF mRNA in gastrocnemius muscle was significantly increased after 1hours and reached a maximum after 2hours. In soleus muscle expression of VEGF mRNA significantly increased after 1<sup>~</sup> 2hours and then decreased gradually to the base line. The expression VEGF protein in gastrocnemius and soleus muscle was significantly increased after lhours and lasted after 12hours. A VEGF mRNA and protein expression were higher in gastrocnemius muscle consist of glycolytic fiber than soleus music consist of oxidative fiber. This VEGF increase in response to hypoxia support the concept that VEGF is involved in hypoxia-induced skeletal muscle angiogenesis.