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Removal of residual chloroform from amorphous paclitaxel pretreated by alcohol
강회종,김진현 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.12
A drying method that can effectively remove residual solvents from chloroform-induced amorphous paclitaxel was developed. Simple rotary evaporation with alcohol (methanol or ethanol) pretreatment was sufficient to remove residual chloroform and alcohol concentrations below the ICH limits (60ppm for chloroform, 3,000ppm for methanol, and 5,000ppm for ethanol). In addition, SEM analysis and ultrasonic treatment showed that residual solvent removal is related to the porous structure of the sample due to the high vapor pressure of the chloroform-alcohol mixture and the hydrogen bonding between chloroform and alcohol.
Taxus chinensis로부터 파클리탁셀 정제를 위한 개선된 아세톤-물 분별침전 공정 개발 및 그 동역학 및 열역학적 해석
강회종 ( Hoe-jong Kang ),김진현 ( Jin-hyun Kim ) 한국화학공학회 2021 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.59 No.3
In this study, an improved acetone-water fractional precipitation process for paclitaxel using ultrasonic cavitation bubbles and gas bubbles was developed. Compared to the conventional method, the time required for precipitation has been reduced by 20~25 times. In addition, the particle size of paclitaxel decreased by 3.5~5.5 times and the diffusion coefficient of paclitaxel increased by 3.5~6.7 times. In the case of precipitation using ultrasonic cavitation bubbles, as the ultrasonic power increased and the temperature decreased, the precipitation rate constant increased. In the case of precipitation using gas bubbles, as the gas flow rate increased and the temperature decreased, the precipitation rate constant increased. Thermodynamic parameters revealed the exothermic, irreversible, and nonspontaneous nature of the improved fractional precipitation.
조철연,강회종,문성용 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.118 No.-
The single-objective and multi-objective optimizations based on a multi-component standing-wavedesignwere carried out for the tandem simulated-moving-bed (SMB) process for continuous-mode separationof galactotriose (G3) from crude galacto-oligosaccharides. This process (named ‘‘G3-SMB”) consistedof two subordinate SMB units. The results from the G3-SMB optimization showed that its twosubordinate SMB units had a significant difference in column efficiency, which acted as a major factorfor restricting the level of attainable throughput and deteriorating solvent usage. This problem couldbe overcome by allowing the use of different column lengths within the G3-SMB (called ‘‘S100 method),which was applied in a way that increased the column length of the subordinate SMB unit under theinfluence of column-efficiency limiting factor while decreasing the column length of the subordinateSMB unit with high column-efficiency. This method led to 32% increase in maximum achievable throughputand 37% reduction in solvent usage. It was also found that the adjustment of column configuration ineach unit (called ”S2 method‘‘) was as effective in improving throughput as the S1 method, but less effectivein reducing solvent usage than the S1 method. Finally, it was confirmed that the simultaneous use ofthe aforementioned S1 and S2 methods could create a synergy effect, thereby resulting in 74% increase inmaximum achievable throughput and 39% reduction in solvent usage.