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타이레놀이알서방정(아세트아미노핀 650 mg)에 대한 타이리콜이알정의 생물학적동등성
강현아,김동호,박선애,윤화,김경란,박은자,조혜영,이용복,Kang, Hyun-Ah,Kim, Dong-Ho,Park, Sun-Ae,Yun, Hwa,Kim, Kyung-Ran,Park, Eun-Ja,Cho, Hea-Yeong,Lee, Yong-Bok 한국약제학회 2006 Journal of Pharmaceutical Investigation Vol.36 No.3
Acetaminophen (paracetamol), a para-aminophenol derivative, has analgesic and antipyretic properties and weak anti-inflammatory activity. The purpose of the present study was to evaluate the bioequivalence of two acetaminophen tablets, $Tylenol^{\circledR}$ ER (Janssen Korea Ltd.) and Tylicol ER (Hana Pharmaceutical Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of acetaminophen from the two acetaminophen formulations in vitro was tested using KP VIll Apparatus II method with pH 1.2 buffer solution. Twenty six healthy male subjects, $22.8{\pm}1.99$ years in age and $65.6{\pm}8.03$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After a single tablet containing 650 mg as acetaminophen was orally administered, blood samples were taken at predetermined time intervals and the concentrations of acetaminophen in serum were determined using HPLC with UV detector. The dissolution profiles of two formulations were similar in pH 1.2 buffer solution. The pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Tylenol^{\circledR}$ ER, were 2.84, 1.89 and -1.36% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log $0.987{\sim}log$ 1.08 and log $0.944{\sim}log$ 1.17 for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Tylicol ER tablet was bioequivalent to $Tylenol^{\circledR}$ ER tablet.
강현아 전남대학교 지역개발연구소 1999 지역개발연구 Vol.31 No.1
This paper analyzed the change of the labor market structure in 1990s and the change of the labor management policy being reorganized after 1987. It was focused on the employment policy. To speak more specifically we tried to see the effects of the labor processes on the labor policy by analyzing the background and the contents of the labor management policy, and the labor-capital conflicts during process. And finally, we explained the results of the labor management policy focusing on the labor market and industrial relations. The finding are as follows. First, the Korean society in the 1980s had faced a situation to change the labor market structure. It was due to the labor shortage and the inequal distribution of labor supply. Thus the intervened directly to the labor management to create the employment flexibility and the stable of labor. Even though the effect of policy was a little position to the management rationalization of the capital, it created the resistance of the labor by conflicting with the labor security. Second, the state started to push the employment policy to increase the labor flexibility since 1993, when the Kim, Young Sam regime started. The employment policy was the legalization of the detachment of labor. But the policy was failed or delayed by the strong opposition of the labor. Third, in labors detachment not only the segregate the labor market but also increased the problem about employment unstability. Their are employed in the short-time job or temporary job.
강현아 전남대학교 사회과학연구소 1996 현대사회과학연구 Vol.7 No.1
This paper attempted to analyze the actual and the limit of women labor policy under the comparing with the women labor policy between Korea and Japan. It is as follows that likenesses and disfferencies of women labor policy between two states. Above all, likenesses are as follows. ① Lay clauses stress on being fixed and magnifing the clauses of women's equality. ② Mitigate and abolish the clauses of women protection. ③ Carry out overall and try to settle the clauses of women's maternity protection. And differencies are as follows. ① In Japan, the principle of women labor policy are that the State or the Society must pay related expenses for protecting women's maternity and this details were enacted as a law, but in Korea, women labor policy are much formal. ② In Japan, reemployment was provided for enlarging employment of married women, but there are not any definite methods for appling married women's labor power in Korea. The limits of women labor policy analyzed through the comparative study with Japan are as follows. ① The actual of women's labor don't become better than a degree to mitigate or abolish the clauses of women protection, but the State force to. This will aggravate the working condition of women labor's. ② The policy that provide the application of working by the how, working at home, transformed working hour for enlarging employment of women, only accelerate the employment unstabilization of women labor's.