http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Structure of Canine Gastrin Gene
강창원,강신애,조혜련 한국유전학회 1989 Genes & Genomics Vol.11 No.4
The full length canine (dog) gastrin gene was cloned from a genomic library by in situ plaque hybridization and mapped with several restriction endonucleases. Two clones containing 12.5 kb and 14.6 kb genomic DNA fragments were isolated among over 500,000 recombinant phages by using the canine gastrin cDNA as a hybridization probe. Restriction mapping of the clones reveals that they share the identical 11.0 kb fragment containing gastrin gene of 2.5 kb. Comparison of partial genomic sequence with cDNA sequence reveals three exons and two introns like human gastrin gene. Splicing junctions are identical to the human and follow the GU/AG consensus sequence rule of mRNA processing. The canine intron I, however, is only 1.7 kb long unlike the human 3.5 kb intron I. The 5’ flanking region of the gene contains the conserved sequence T-A-T-A-A, which is present at 26 bp upstream from the putative cap site. The sequence G-A-C-T-C-A-T-A-T, found at 86 bp upstream in the human and other eukaryotic genes, is not detected. The sequence T_5-A₂-T-A-T₄-A-C-T₂-A-T₃-A-T₃-A-T₃, similar to a human RNA polymerase II terminator sequence T_9-A₂-T_5-A-T₄-A-T₄-A-T₄, appears to be the canine terminator. However, it has a inverted repeat of 6.5 bp sequence instead of the human 10.5 bp repeat unit.