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강정대 ( Kang Jeong Dae ),김소진 ( Kim So Jin ),윤녕훈 ( Yun Nyeong Hun ),박석돈 ( Park Seog Don ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.11
Cutaneous extramedullary plasmacytomas are rare in patients with multiple myeloma, they usually indicate a large tumor cell burden and fatal outcome. A 55-year-old man presented with multiple cutaneous tender nodules or masses on whole body. A biopsy specimen of cutaneous nodule showed dermal infiltration by well differentiated plasma cells. Many atypical and immature plasma cells were found in a bone marrow smear and biopsy. A serum protein electrophoresis revealed elevated quantities of Ig G-globulin with type 入 light chain. The patient was treated with VAD(vincristine, adriamycin, dexamethasone) chemotherapy, but died with pulmonary edema and acute respiratory distress syndrome. We report a fatal case of multiple myeloma first presenting as multiple extramedullary cutaneous plasmacytomas. (Korean J Dermatol 2003;41(11) : 1517∼1520)
포도구균성 열상 피부 증후군 25예의 임상적 분석에 의한 재분류
강정대 ( Kang Jeong Dae ),박석돈 ( Park Seog Don ) 대한피부과학회 2004 대한피부과학회지 Vol.42 No.4
N/A Background: Dermatofibromas are common benign tumors which occur in the skin. They have been divided into fibrous lesions, composed entirely of almost entirely of fibroblasts and collagen, and cellular lesions composed to a significant degree of phagocytic cells with the appearance of histiocytes. A cellular variant characterized by increased cellularity, storiform arrangement, larger size, and location in the deep dermis, often with extension into the superficial subcutaneous tissue may be difficult to differentiate from dermatofibrosrcoma protuberans. There is an incessant controversy over the histogenesis of dermatofibromas, although many authors consider that these tumors derive from primitive mesenchymal cells. The recent development in immunohistochemical staining technology and ultrastructural study revealed various cellular proliferation in the lesion, including fibroblast, histiocyte and myofibroblast. Objective: Our purpose was to study by immunohistochemistry the defferences between fibrous and cellular dermatofibromas and to find the relationship between the myofibroblast and the histogenesis of dermatofibroma. Methods: We will select 36 cases of dermatofibromas which include 27 fibrous and 9 cellular types. We have studied the immunophenotype of 36 dermatofibromas using antibodies against vimentin, smooth muscle actin, desmin, CD34, factor XⅢa, CD68 and MMP 11. Results: All dermatofibromas were positive for vimentin, smooth muscle actin, and factor XⅢa, but negative for desmin and CD34. All cellular type were positive for CD68, but 24/27 of the fibrous type were positive for CD68. MMP 11 was positive in 6/9 of the cellular type and 25/27 of the fibrous type. The degree of staining for vimentin, factor XⅢa, CD68, and MMP 11 was not different in both types. But the degree of staining for smooth muscle actin in the fibrous type was higher than in the cellular type. Conclusion: The differences in the degree of staining for smooth muscle actin and the positivity for CD68 suggest the possibility of a different differentiation of dermatofibroma between cellular and fibrous types. The prominent vimentin and smooth muscle actin immunoreactivity and desmin non-reactivity may suggest that the myofibroblast may play a role, in part, for developing dermatofibromas. Further investigations with ultrastructural study using electron microscopy and double/triple immunohistochemical staining would be necessary. (Korean J Dermatol 2004;42(3):256~263)
위상 및 형상 최적화기법에 의한 샤시부품의 국부동강성 및 경량화 효과
박정훈(Jeong-hun Park),전승태(Seung-tae Jeon),이태진(Tae-jin Lee),강정대(Jeong-dae Kang),강명창(Myung-Chang Kang) 한국기계가공학회 2018 한국기계가공학회지 Vol.17 No.3
Recently, interest in customers has shifted to the emotional quality of customers as the driving, handling, and collision stability of automobiles have been greatly improved. The NVH performance of a vehicle is quantified and evaluated from the DPDS. To improve the DPDS, we need to optimize the shape without considering the increases in thickness of the parts or additions to the parts. And at the same time, we need to establish design and analysis processes to satisfy the requirements of the DPDS.