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N2O-Thiopental 및 Lidocatine 마취지 뇌척수압의 변화에 관한 연구
정규섭,강용업,백승완 대한마취과학회 1987 Korean Journal of Anesthesiology Vol.20 No.5
In patients undergoing intracranial surgery, the drugs used for anesthesia and the operative procedure can effect an increase in intracranial pressure. Especially in patients whose intracranial pressure has already increased significantly, if the pressure is further increased br these factors, then the patient's neurological condition may be aggravated and the post-operative prognosis may be affected. Thus it is desirable to use drugs which reduce intracranial pressure during this type of surgery. In this study, the spinal subarachnoidal pressures of two groups were compared. One group received a combination of thiopental sodium and lidocaine which are known to relatively reduce intracranial pressure, white the other group was given halothane which is known to increase intracranial pressure. The summary of this study is as follows : 1) The spinal subarachnoidal pressure began to increase 1∼4 minutes after the administra-tion of halothane, and the duration of increament was 15-38 minutes with a maximal presure change from 346±63 mmH_2O to 417±90 mmH_2O. Thereafter the pressure returned to the preinduction level spoataneously. 2) The spinal subarachnoidal pressure began to decrease 2∼4 minutes after the administration of thiopental sodium and lidocaine. The greatest decrease in pressure occurred within 10∼15 minutes level as the Preseure fell form 324±41 mmH_2O to 210±73 mmH_2O, thereafter the pressure remained decreased.
백승완,김해규,정규섭,강용업,김인세,백선용 대한마취과학회 1993 Korean Journal of Anesthesiology Vol.26 No.3
소의 신선한 대뇌피질로부터 분리한 synaptosomal plasma membrane vesicles(SPMV)에서의 barbiturates 침투정도를 형광 probe법으로 검색하였다. Barbiturates는 SPMV 외부 단층(outer monolayer)의 표면에 주로 분포하되 지질용해도와 마취능에 비례하여 소수성 부위에 분포되는 양이 증가되는 현상을 보여주었다. Thiopental sodium, pentobarbital, hexobarbital, amobarbital 및 phenobarbital은 SPMV 외부 단층의 표면(친수성 부위)에 분포되는 것이 소수성 부위에 분포되는 것에 비하여 각각 4.3, 20.6, 22.1, 39.8 및 49.2배가 된다는 것을 확인하였다.