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위선종, 위선암종에서 c-erbB-2, c-met 단백 발현
이승우 ( Seung Woo Lee ),강상범 ( Sang Beom Kang ),김연수 ( Yon Soo Kim ),남순우 ( Soon Woo Nam ),이동수 ( Dong Soo Lee ),이혜경 ( Hye Kyung Lee ),한석원 ( Sok Won Han ) 대한소화기학회 2007 대한소화기학회지 Vol.49 No.3
Background/Aims: The aim of this study was to investigate the immunohistochemical overexpression of c-erbB-2 and c-met proteins according to the histopathological parameters such as grade of dysplasia, histological type, depth of invasion, lymph node metastasis, and TNM stage in gastric adenoma and gastric adenocarcinoma. Methods: Immunohistochemical staining using monoclonal c-erbB-2 and c-met antibodies was performed on paraffin embedded specimens in 43 adenomas and 44 adenocarcinomas. Results: The expression rate of c-erbB-2 was higher in adenomas (91%) than adenocarcinomas (30%). The expression rate of c-met was higher in adenocarcinomas (77%) than adenomas (49%). In adenoma, the expression rate of c-met was higher in high grade dysplasia (94%) than in low grade dysplasia (22%). In adenocarcinoma, c- met expression was significantly related with lymph node metastasis. Conclusions: c-erbB-2 would be involved in the development of relatively early stage gastric carcinogenesis. c-erbB-2 is related with histologic type and c-met with lymph node metastasis in gastric carcinomas. Although meaning for the experession of these proteins in gastric carcinomas would be different, these proteins may play as important oncogenes in gastric carcinogenesis. (Korean J Gastroenterol 2007;49:152-157)
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