http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 강복기 ( Bok Ki Kang ) (검색결과 6 건)
- 무료
- 기관 내 무료
- 유료
-
-
강복기,강길선,김종민,정상영,이해방,조선행 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3
Melatonin (MT) is an indole amide pineal hormone. It has not only very short half-life but also pH-sensitive property. The sustained release dosage form which delivers M in a circadian fashion over 8 h is clinical value. The purpose of this study is to prepare sugar beads using multiple coating methods and enteric-coated in a sustained release to evaluate in vitro release characteristics in simulated gastric and intestinal fluids. The Eudragit^(?) as a polymer, sustained release membrance, and triethylcitrate (TEC) as a plasticizer were used. Multi-coated melatonin delivery system was composed of sugar, various excipients, Eudragit^(?) and enteric materials (e.g. hydorxy propyl methyl celluslose phthalate, HPMCP), and prepared by fluid bed coater. The dissolution test was carried out using the basket method at a stirring speed of 100 rpm at 37℃ in simulated gastric (pH 1.2) and intestinal fluid (pH 7.4). The released amount of MT was determined by High performance liquid chromatography method. The morphologies of surface and cross section of multi-coated beads were observed by scanning electron microscope. Size of multi-coated sugar beads was ranged over 1000∼1300 μm. The release rate of MT from coated beads was limited in simulated gastric fluid (pH 1.2), but it was sustained in intestinal fluid (pH 7.4) during 3∼8 hours. The MT beads may provide small-intestine-targeted device for oral delivery. Studies an animal and relative experiment are in process.
-
심바스타틴 자가유화약물전달시스템의 마이크로캡슐화를 통한 고형제제의 개발
강복기,윤복영,서광수,정상영,길희주,강길선,이해방,조선행 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2
The objective of this study was to solidify the simvastatin self-microemulsifying drug delivery system (SMEDDS) and to improve the encapsulation efficiency of solidified alginate beads using sodium alginate. Typical simvastatin SMEDDS was composed of various oils, surfactants and cosurfactants. Also solidified-alginate beads was prepared by corsslinking liquid emulsion mixtures containing sodium alginate and other excipients (cetylpyridinum chloride (CP-CI), hydroxypropyl methylcellulose, starch and so on), in CaCl_2 solution, it has been investigated that the drug release pattern and encapsulation efficiency were varied with the ratio of cationic lipid (CP-CI). Solidified sodium alginate beads containing simvastatin SMEDDS were redispersed into media without re-aggregation. Oil droplet size of redispersed solidified-beads in media produced smaller than the initial size. The density of beads and drug loading amount were increased with increasing cationic lipid content. These systems have advantages of storage stability and predictability of drug release rate.
-
미세유화약물송달시스템을 이용한 로바스타틴의 생체이용률 향상
윤복영,강복기,정상영,이영원,이시범,황성주,육순홍,강길선,이해방,조선행 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4
A self-microemulsifying drug delivery system (SMEDDS) was developed to increase the dissolution rate, solubility, and ultimately bioavailability of a poorly water soluble drug, lovastatin. SMEDDS was the mixtures of oils, surfactants, and cosurfactants, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastro-intestinal (GI) tract. Various types of self-emulsifying formulations were prepared using four types of oil (Capryol 90, Lauroglycol 90, Labrafil M 1944 CS and Labrafil M 2125), two surfactants (Cremophor EL and Tween 80), and three cosurfactants (Carbitol, PEG 400 and propylene glycol). The efficiency of emulsification was studied using a laser diffraction size analyzer to determine particle size distributions of the resultant emulsions. Optimized formulations selected for bioavailability assessment were Carpryol 90 (40%), Cremophor EL (30%) and Carbitol (30%). SMEDDS containing lovastatin (20 mg and 5 mg) were compared to a conventional lovastatin tablet (Mevacor^? , 20 mg/tab) by the oral administration as prefilled hard gelatin capsules to fasted beagle dogs for in vivo study. The area under the serum concentration-time curve from time zero to the last measured time in serum, AUC_0→24h, was significantly greater in SMEDDS, suggesting that bioavailability increase 130% and 192% by the SMEDDS, respectively. The self-emulsifying formulations of lovastatin afforded the improvement in absolute oral bioavailability relative to previous data of lovastatin tablet formulation. These data indicate the utility of dispersed self-emulsifying formulations for the oral delivery of lovastatin and potentially other poorly absorbed drugs.
-
이해방,이동헌,강복기,정상영,강길선 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4
Such osmotic drug delivery systems are based on osmosis, the diffusion of water transversely from a medium with a low osmotic pressure to a medium with a high osmotic pressure for the controlled delivery of active agents. In this review, U.S. Patents on osmotic drug delivery analyze 261 patents until December 2001. These devices form now a major market of drug delivery products. Because of their advantage and innovate idea, it appears that the future of oral drug delivery market in Korea is promising.
-
자가미세유화를 이용한 이부프로펜 액상제제의 제조와 특성
안용산,송지희,강복기,김문석,조선행,이종문,이해방,강길선 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1
Ibuprofen (IBU), is a non-steroidal anti-inflammatory drug, used to treat rheumatoid arthritis, removal of fever and mild to moderate pain. Because of small dosage and very low accumulation in the body, IBU has been used to heal children's fever. However, IBU was very low solubility in a low pH and water (in water 0.03∼2.5 ㎎/ml). A nanoemulsion containing IBU by means of self-micromulsion drug delivery system (SMEDDS) was prepared in order to enhance the solubility of IBU. The SMEDDS was composed of cosurfactant, oil and surfactant. The solubility of IBU in various components such as cosurfactant, oil and surfactant was examined. Carbitol^(??) (389.99±20.5 ㎎/ml) as a cosurfctant, Labrafil^(??) M1944CS (90.16±1.60 ㎎/ml) as an oil and Cremopher^(??) RH-40(239.01±2.8 ㎎/ml) as a surfactant were used in this study for preparing SMEDDS. Optimized formulation of SMEDDS was obtained by phase diagram which express the section of nanoemulsion formation. The SMEDDS containing IBU had higher dissolution rate than conventional IBU sirups. Thus the SMEDDS was a potential candidate of stable conventional and effective oral dosage form for IBU.
ScienceON연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
