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송지영,양현옥,표석능,박신영,김기환,손은화,강남성,윤연숙,Song, Jie-Young,Yang, Hyun-Ok,Pyo, Suhk-Neung,Park, Sin-Young,Kim, Ki-Hwan,Son, Eun-Hwa,Kang, Nam-Sung,Yun, Yeon-Sook 대한약학회 1998 약학회지 Vol.42 No.2
Currently, cancer is the primary cause of death and 50% of cancer patients are incurable by surgery, radiotherapy and chemotherapy. Therefore, immunotherpy is interested as the fourth remedy. Biological response modifier (BRM), such as organometallic compounds, glycoproteins, polysaccharides and other natural products. Is the one which can enhance the immune response against cancer cell. To develop new BRM from natural sources, we investigated 63 species Korean traditional medicines by observing the mitogenic activity to splenocytes, generation of activated killer cells and activation of macrophages. Finally, we selected 9 species including Angelicae gigantis Radix, Mori Cortex Radicis, Arisaematis Tuber, Salviae Radix, Cnidii Rhizoma, Ligusti Fructus, Pasoraliae Semen, Loranthi Ramulus, Ginseng Radix. Bioassay-guided fractionation and purification is undergoing.