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Tibolone이 폐경 후 골감소증 환자의 골밀도에 미치는 영향
강길전 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1
To investigate the effects of tibolone on trabecular and cortical bone mineral density (BMD) in postmenopausal women with osteopenia, a 2-year, randomized, double-blind, placebo-controlled study was tried. 36 women were treated with tibolone as study group and 31 with calcium as control group. Trabecular BMD of lumbar spine(L1 to L4) and cortical BMD at the femoral neck were assessed by dual energy x-ray absorptiometry at baseline and at 6-month intervals. After 2 years, subjects in the tibolone group gained 7.9% bone mass at lumbar spine and 4.5% at femoral neck, and respective increases from baseline in the placebo group were 3.5% and 2.0%. Tibolone-treated patients gained statistically significantly more bone mass than placebo-treated patients in the spine and femur. This study showed that Tibolone induced a significant increase in trabecular (lumbar spine) and cortical (femoral neck) bone mass in postmenopausal osteopenic women compared to placebo.
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강길전,이기환 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2
The treatment of severe intrauterine synechia is not known. So if patient with severe intrauterine synechia wants pregnancy, it is doctor's dilemma. In this situation, this study was designed for develpment of new method for treatment of severe intrauterine synechia. For this study, 15 women with severe intrauterine synechia were included and about 6 years were requested from January 1991 to July 1996. Under general anesthesia, all patients were performed laparotomy and then cervical and intrauterine cavity were dilatated gradually by Hegar dilatator, while the first assistant operator guided the direction of Hegar dilatator through laparotomy opening. Finally utero-tubal junction was communicated by use of uterine sound. At this time the first assistant guided the direction of the uterine sound through laparotomy opening. With this new method of procedure, intrauterine cavity was normalized in 100%, but one or both utero-tubal junction were obstrcted in 33.3%. However, five women(33.3%) become pregnant. There was one episode od uterine perforation during this new procedure.
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姜吉田 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2
This study was undertaken to investigate the clinical and pathological characterisitics partial hydatidiform mole. During past three years period, 13 patients with partial hydatidiform mole observed at this department of Chungnam National University Hospital. The obtained results were as follows: 1. Age of 23% of patients was over 40 years old. 2. The uterine size was small for date in 84.6% of patients. 3. No patient had theca lutein cysts. 4. Preevacuation urine HCG level was 1,000-10,000 IU/L in 69.2% of patients. No patient showed excess of 100,000 IU/L. 5. The preevacuation diagnosis in about 54% by sonogram was either missed abortion or complete hydatidiform mole. 6. After evacuation, one (7.7%) patient developed nonmetastatic persistent trophoblastic disease.
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강길전 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2
To examine the relationship between obesity and reproduction, 20 obese women and 20 agematched normal menstruating worsen were compared. Serum FSH, LH, PRL, testostosteron, progesterone, estradiol, cortisol and DHEAS during follicular phase were measured by RIA. The obtained results were as follows: 1. The indirect evidence of GnRH was significanlty elevated in obese women. 2. Th serum level of LH was significantly elevated in obese women, but serum FSH and prolactin were not significantly changed in obese group. 3. The serum level of progesterone was significantly decreased in obese women and testosterone level was significantly elevated in obese women. But the serum level of estradiol was not changed. 4. The serum level of DHEAS was significantly elevated in obese women, but cortisol level was not changed Thus, obseity is associated with abnormalities in hormonal balance, especially in hypothalamic GnRII, LH and adrenal DHEAS.
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강길전,이기환,박윤석 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2
To examine the impact of amenorrhea on bone mineral density in women of reproductive age, 22 amenorrheic women aged 16-40 were studied Bone mineral density in the lumbar spine(L1-L4) as measured by dual energy X ray absorptiometry. The amenorrheic group showed a mean reduction in bone mineral density of 155 as compared with controls. Bone loss was related to the duration of amenorrhea and the severity of estrogen deficiency rather than to the underlying diagnosis. Patients with a history of fracture had significantly lower bone density than those without a history of fracture. In conclusion, amenorrhea in young women should be investigated and treated to prevent bone mineral loss. Menopausal women with a past history of amenorrhea should be considered to be at high risk of osteoporois.
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암의 식이요법 : 항산화제를 중심으로 About Antioxidant Therapy
강길전 한국정신과학학회 2002 한국정신과학회 학술대회 논문집 Vol.16 No.-
그 동안 수 십 년에 걸친 암의 역학 조사에 의하면 암은 주로 환경요인, 음식, 생활습관, 스트레스 및 유전인자와 밀접한 관계가 있는 것으로 알려져 있다. 이 중에서 음식이 암의 원인으로 차지하는 부분은 약 30%~50% 정도로 알려져 있고 음식이 암을 유발하는 근저에는 과잉 프리래디칼(free radical)이 작용하고 있음이 밝혀졌다. 따라서 체내에서 발생하는 과잉 프리래디칼을 잘 처리할 수만 있다면 암을 예방할 수 있을 것이라는 기대를 갖게 되었다, 이리하여 영양 종양학(nutritional oncology) 및 분자교정 종양학(orthomolecular oncology) 및 프리래티칼학(free radical)이라는 새로운 분야가 등장하여 꾸준히 발전하고 있으며, 또한 영양만으로 질병을 치료 하는 영양치료 클리닉(nutritional clinic)도 많이 생기고 있는 실정이다. 우리 나라에서도 기초의 학, 약학 및 생물학 분야 동에서 활성산소에 관한 많은 연구가 진행되고 있다. 그러나 주류의학의 종양학자들은 항산화제를 암 환자의 치료에 병합치료 하는 것을 반대하고 있는 실정이다. 따라서 이러한 논쟁의 중심에 있는 항산화제와 암의 치료라는 주제를 가지고 고찰하였다.
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강길전,이기환,박윤석 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2
Thirty-eight healthy, perimenopausal women (aged 42-54 years) were allocated to 6 months of over of treatment with a cyclic combination of 2 mg estradiol valerate and 1 mg cyproterone acetate. 1. Satisfactory response to hormonal treatment was noticed in 32 patients (84.2%), but unsatisfactory response was noticed in 6 patients (15.8%). 2. Unsatisfactory response was especially noticed in group of patients who were in regular menstruation but complaines of menoparsal wymtoms. Accordingly, if unsatisfactory response was noticed, other couses of menopausal symptoms were evaluated, especailly ofr psychologic factor or stress factor. 3. After hormonal treatment body weight and blood pressure were not singificantly chanded. 4. After hormonal treatment GOT, GPT, alkaline phospatase, BUN, FBS, creatinine, triglycerid, HDL-cholesterol and total cholesterol were not significantly changed. 5. Side effects of durg were negligible and patiens were well tolerated the drug and compliance were good. On conclusion, it has suggested that a combination of estradiol valerate and cyproterone acetate was safe and effective for the treatment of menopausal symptoms without side-effects. However effects on bone density with this durg should be evaluated.
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