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- 저자 : 黃元九(Hwang Won Koo) (검색결과 5 건)
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Evaluation for Biocompatibility of Gentamicin-collagen Sponge on the Experimental Animal Wound Model
윤성호,박지희,박정규,김만섭,김달원,송문용,강규일,황원구,구세광,장광호,권영삼,Yun, Sung-Ho,Park, Jihee,Park, Jeongkyu,Kim, Manseop,Kim, Dalwon,Song, Moon-Yong,Kang, Gyoo-Il,Hwang, Won-Koo,Ku, Sae-Kwang,Jang, Kwang-Ho,Kwon, Young-Sam The Korean Society of Veterinary Clinics 2015 한국임상수의학회지 Vol.7 No.2
The objective of this study was to compare the biocompatibility for local irritation and bioavailability of $Gentacol^{TM}$ and $Collatamp^{TM}$, after single intramuscular loading in rats. Sixty-six male Sprague-Dawley rats were divided into 4 groups; (1) any test materials were not applied into the quadriceps muscles (control group, N = 6), (2) Gentamicin was injected into the quadriceps muscles (Gentamicin group, N = 6), (3) Collatamp was applied into the quadriceps muscles (Collatamp group, N = 27), and (4) Gentacol was applied into the quadriceps muscles (Gentacol group, N = 27). The concentration of gentamicin in muscles was gradually decreased with time after loaded in the both $Gentacol^{TM}$ and $Collatamp^{TM}$ loaded regions. No detectable gentamicin was observed in the plasma of $Gentacol^{TM}$ and $Collatamp^{TM}$ loaded rats. Histologically, moderate to severe inflammatory cell infiltrations including PMN, lymphoid cells and macrophages were observed with slight to moderate edematous changes of muscle fibers after intramuscular injection of gentamicin. However, these histopathological changes of gentamicin injection induced local irritations were dramatically decreases after intramuscular loading of $Collatamp^{TM}$ and $Gentacol^{TM}$. These results suggest $Gentacol^{TM}$ may show favorable local bioavailability and induce only slight local irritations as comparable as $Collatamp^{TM}$ without systemic exposures in the condition of this experiment. 본 연구의 목적은 겐타마이신 함유 스폰지인 겐타콜과 콜라템프를 랫드 근육내 이식 후 생체적합성을 비교하는 것이다. SD 랫드 66 마리를 네 그룹으로 나누었다; (1) 대퇴사두근에 무처치한 군 (대조군, 6 마리), (2) 대퇴사두근에 겐타마이신 액을 주사한 군 (겐타마이신 군, 6 마리), (3) 대퇴사두근에 콜라템프를 이식한 군 (콜라템프 군, 27마리), (4) 대퇴사두근에 겐타콜을 이식한 군 (겐타콜 군, 27 마리). 겐타콜과 콜라템프 이식 한근육 내 겐타마이신 농도는 시간이 지남에 따라 점차 감소하였다. 혈액 내에 겐타마이신 농도는 측정되지 않았다. 조직학적으로 겐타마이신액을 주사 후 근육 내에 다형핵백혈구, 림프구, 대식세포를 포함하는 염증세포가 중등도에서 심하게 침윤되었고, 경도에서 중등도의 근육내 부종이 관찰되었다. 그러나, 이러한 국소 자극의 조직학적 변화는 콜라템프와 겐타콜 군에서는 현저히 감소하였다. 이상의 결과, 겐타콜은 콜라템프와 비교하였을 때에 전신적인 영향을 미치지 않으며 국소자극의 정도가 유사하였고, 생체이용성이 유사하여 좋은 생체적합성을 가지는 것으로 생각된다.
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黃元九 亞細亞文化硏究 1999 亞細亞文化硏究 Vol.3 No.-
The relationship between Ch`ing and Choson was a relationship established within the realm of China`s perspective of international order. But, from the late 18th century and on, the relation toward Ch`ing shifted from essential that of a tributary state to a quasi-tributary state. Before this shift the emphasis of the relationship primarily centered on protocol, economy and politics. With the change, though, the emphasis now was on cultural relations. Before Ch`ing had united China it had caused severe economic hardship for its neighbors and Choson was no exception. As such, Choson had a negative view of Ch`ing until Keonryung era. From this time and on, economic burden became lightened and cultural ties began to increase. This change in the nature of the relationship brought about gradual improvement in viewing Ch`ing. Sino-Korea relationship had always been shaped by utility and justification, today and back then. Factors such as whether China was in a state of unification, divisive state, Han-ruled state, or ruled by other conquerors determined each country`s position toward each other. Of course, for China, whether Korea was in a state of unification or a divisive state was also important. But, when compared, the two country`s relationship can be better expressed in terms of utility rather than justification. Likewise, academic exchange and it`s result that occurred between Sino-Korean scholars in the 18th and 19th century was no exception.
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Metal Complex-Catalyzed Olefin Epoxidations by Iodosylbenzene
Hwang, Won-Koo,Nam, Won-Woo 弘益大學校 科學技術硏究所 1993 科學技術硏究論文集 Vol.3 No.-
여러종류의 금속착물을 촉매로 사용하여 요오도실벤젠의 산소원자를 올레핀으로전달하는 반응 메카니즘을 연구하였다. 위의 반응에서 에폭사이드가 주 생성물로 형성되었고, 시스-스틸빈의 산화반응에서는 시스-스틸빈 옥사이드와 트랜스-스틸빈 옥사이드가 동시에 생성이 되는 것을 반견했다. 금속착물에서의 금속 이온과 리간드는 착물의 반응성에 큰 영향을 나타내지 않았고, 이와 같은 결과로 유추하여 산소원자를 전달하는 활성종으로는 금속-요오도실벤젠 결합체로 추정을 하였다. 이에 대한 반응 메카니즘에 대하여 논하였다.
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