http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
발암물질이 배양 생쥐 포세포에 미치는 세포유전학적 영향
한사숙,정영란,정용재 ( Sah Sook Hahn,Young Lan Chung,Yong Jai Chung ) 한국유전학회 1981 Genes & Genomics Vol.3 No.1
The present study was undertaken in an attempt to compare sensitivity of mutagenecity of two kinds of carcinogens: dimethylnitrosamine(DMN), diethylnitrosamine(DEN) on chromosome level by examining metaphase chromosomal aberrations and sister chromatid exchanges (SCEs). The five kinds of dosages of DMN and DEN (1×10-6, 5×10-6, 1×10-5, 5×10-5 and 1×10-4 M) were applied to the cultured embryonic cells of mouse and the results thus obtained are presented below: 1. The types of chromosome aberrations were found to be mainly chromatid gaps, chromosome breaks, chromosome exchanges and dicentrics. Chromosome aberrations showed increase of frequencies as dosage of carcinogen increased and the total chromosome aberrations were detected to be higher in DMN than in DEN treatment. 2. Cells treated with only BUdR showed 7.06±0.34/cell of SCEs and cells treated with DMN and DEN showed increase of and 2.06 times of SCE production from BUdR treated control respectively. SCE frequencies increased as dosages of carcinogens increased and it was also shown that DMN treatment produced more SCEs than DEN did. 3. The SCE test method was manifested to be approximately 15 times more sensitive than conventional metaphase chromosome aberration score method. 4. The DMN was also found to be more potent agent for inducing chromosome aberrations and SCEs than DEN.
Effect of Alkylating Agents on Cultured Uterine Carcinoma
Kim, Song Sik,Hahn, Sahsook 최신의학사 1977 最新醫學 Vol.20 No.9
자궁암 조직을 배양하여 그들의 염색체를 관찰, 분석하고 알킬화제인 Methyl methanesulfonate(MMS)와 Ethyl methanesulfonate(EMS)를 배양한 자궁암 세포에 처리하여 세포 사망율과 염색체 이상을 비교 관찰하여 다음과 같은 결과를 얻었다. 1. 종족세포의 염색채수는 그 주범위가 42에서 48이었다. 2. 세포 사망율에 의하여 EMS보다 MMS의 독성이 더 높은 것을 보여 주었다. 3. 두 알킬화제 처리에서 다 같이 단일 염색분체 결실이 주로 일어났지만 EMS가 MMS 보다 낮은 결실율을 보였고 동원제(centromere)에 선택적으로 결실을 보였다. 4. MMS와 EMS의 작용양식을 비교 고찰하였으며 두 화학물질 사이에 상이한 반응을 보여 주는 것은 작용양식의 차이에 의한 것임을 시사한다. The chromosome constitutions of cultured human uterine carcinoma was studied and comparison of two alkylating agents (MMS and EMS) were made as respect to the survival rate and induced chromosomal aberrations under various concentrations. The results obtained were as follows: 1. The chromosome constitution of cultured human uterine carcinoma showed major range of 42 to 48. 2. The cell survival rate indicated that MMS were more toxic than EMS. 3. Although, a single chromatid breaks were the most common type of breakage with both MMS and EMS, the frequency of the breakage induced by EMS was notably lower than MMS and relatively specific to centromeric regions. 4. Two monofunctional alkylating agents were compared and discussed with respect to mode of action and suggested that the differential responses are produced depending on the mode of action.