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閔弘基,韓雲燮 梨花女子大學校 醫科大學 醫科學硏究所 1985 EMJ (Ewha medical journal) Vol.8 No.2
The main objective of the present study is to identify the evidences of mu-cinous cell metaplasia and goblet cell metaplasia of the bile duct epithelial cells in rats. For the purpose, male albino-rats(Winstar strain) were infected with 100 Clonorchis metacercariae. On the scheduled day at one month interval from the end of the 1st month after infection up to the 15th month, three rats were sac-rificed by general ether anesthesia. The hepatobiliary tissues were extracted, fixed in 10% formalin solution, sectioned serially and stained with haematoxylin and eosin for histopathologic examination. Alcian blue stain was also applied, if nece-ssary. The results obtained are summarized as follows ; 1) At the end of the 1st month after infection, the bile ducts showed marked epithelial cell hyperplasia, adenomatous tissue proliferation, papillary tissue for-mation, mitotic figures, atypia and stratification of epithelial cells. The periductal and portal spaces demonstrated a mild fibrosis with inflammatory cells consisted of majority of polymorphonuclear leucocytes and eosinophils. 2) From the 2nd month after infection, adenomatous hyperplastic glands de-monstrated some focal mucinous cell metaplasia, with subsequently development of goblet cell metaplasia. Most of fibrosis were replaced by collagen fibers. Chro-nic mononuclear leucocytes were dominating. 3) From the 4th month to the 6th month, all the pictures reached the zeniths in their degrees, and sustained the peaks up to the 10th month or 11th month, then the figures showed gradual regression.
長期 肝吸蟲感染마우스의 膽管系 變化 : 病理組織學的 所見을 中心으로
閔弘基,韓雲燮 梨花女子大學校 醫科大學 醫科學硏究所 1985 EMJ (Ewha medical journal) Vol.8 No.1
The main objective of the present study was to obtain further information on the histopathologic changes in the bile ducts at chronic stage of Clonorchis sinensis infe-ction for the establishment of relationship between clonorchiasis and cholangiocarcin-oma. BALB/C male mice were used. Approximately 500 metacercariae were given orally to each mouse. Three mice were sacrificed once monthly from the 10th month thro-ugh the 20th month after infection. The hepatobiliary tissues were fixed in 10% form-alin solution, sectioned serially, and stained with hematoxylin and eosin for histopat-hologic examination. The results obtained are summarized as follows; 1) The bile ducts showed moderate adenomatousproliferation, mucinous cell met-aplasia and goblet cell metaplasia from the 10th month up to the 13th month after infection, then gradual regression. As time elapsed, scattered abortive acini were aslo regressive. 2) Most of the stromal fibrous tissues were replaced by excessive collagen fibers which persisted throughout the observation. The pictures were considered to be irre-versible. 3) Polymorphonuclear leucocyte and eosinophil infiltrations was slight in the de-gree, while chronic mononuclear leucocyte infiltration was moderate throughout the observation. 4) Even though no any evidence of malignant change of epithelial cells was dem-onstrated thoughout the observation, Clonorchis infection was considered to be an impotant predisposing factor in carcinogenesis in the bile ducts.