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- 저자 : 金麒淳 (검색결과 397 건)
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Taurine이 histamine에 의해 유발된 가토 동방결절 세포의 막전압 및 부정박동에 미치는 효과 : Antiarrhythmic Effect of Taurine
황보상,김진혁,고상돈,신홍기,김기순 한양대학교 의학교실 1988 한양의대 학술지 Vol.8 No.2
Effects of taurine and histamine on the electrophysiological characteristics of the rabbit sinus node cells were investigated by a conventional microelectrode technique. Also studied was the effect of taurine on histamine-induced changes in the action potential of the pacemaker cells, as well as on histamine-induced arrhythmias. When the sinus node cells were exposed to histamine the overshoot potential, consequently action potential was decreased, action potential duration was shortened and the rate of spontaneous firing increased markedly. Effect of histamine on the cellular potential peaked between 5 to 10 minutes after superfusion of the cardiac pacemaker cells. On the other hand, taurine (0.01-0.5%) did not affect the transmembrane potential of the rabbit sinus node cells. After pretreatment of the cardiac pacemaker cells with taurine, effect of histamine on the action potential amplitude was depressed prominently whereas action potential duration was not altered by histamine. Histamine-induced tachycardia or dysrhythmia were significantly supressed in 1-2 hours following superfusion of the sinus node cells with taurine solution. The possible mechanism underlying antiarrhythmic action of taurine on histamineinduced arrhythmia was discussed. It is concluded that taurine has a protective action against adverse effects of histamine on the cardiac pacemaker cells of the rabbit heart.
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腎臟切除 自發性高血壓白鼠의 혈압 및 성장에 미치는 Vanadate 의 영향
金正鉉,金鎭爀,金基淳 한양대학교 의과대학 1986 한양의대 학술지 Vol.6 No.1
Vanadium, a trace element essential for normal development and growth of animals was recently found to be a potent inhibitor of Na-K-ATPase. Vanadate is known to inhibit adenylate cyclase, glucose-6-phosphatase, Ca-ATPase and alkaline phosphatase as well. Though the cellular activity of vanadate is similar to that of ouabain in some respect, it dose not faithfully mimic all of the effects of cardiac glycosides. It has been known that vanadate stimulates the contractile activity of the heart and blood vessels and that urinary excretion of this element is increased in some patients with essential hypertension. Recently it was reported that following prolonged dietary administration of vanadate systolic pressure of uninephrectomized rat elevated significantly due to increased total peripheral resistance. Therefore the present study was designed to explore effects of vanadate on development of hypertension in the normal spontaneously hypertensive rats (SHR) and on blood pressure of the uninephrectomized SHR. Also studied was effect of vanadate on the growth of hypertensive rats. This experiment consists of two series. In the first series different doses of vanadate (0.5 mg, 2.5 mg and 5.0 mg/kg/day) were orally administered to SHR for 12 weeks while in the second series vanadate (2.5 mg and 5.0 mg/kg) was given to uninephrectomized SHR for 10 weeks. The results obtained can be summarized as follows: 1. Development f hypertension in SHR was not significantly affected by administration of vanadate as much as 5.0 mg/kg/day. 2. In uninephrectomized SHR administration of vanadate (2.5 mg and 5.0 mg/kg) for 10 weeks did not alter systolic pressure significantly. 3. Growth of normal or uninephrectomized SHR was not altered by the ingestion of vanadate (5.0 mg/kg/day) for 10 weeks. 5. Removal of one kidney did not cause any significant changes in growth or systolic pressure of SHR. These findings indicate that so long as blood pressure and growth are concerned ingestion of vanadate as much as 5.0 mg/kg/day for 10 weeks is not hazardous to mammals.
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장기간 Nicotine 및 Ethanol 을 섭취한 자발성 고혈압 백서의 혈압 및 체중변동
안성기,구자란,강석한,이애주,김기순 한양대학교 의학교실 1988 한양의대 학술지 Vol.8 No.2
Changes in the systolic pressure and body weight were studied in both sexes of spontaneously hypertensive rats treated chronically with nicotine (4.5mg/kg/day) or/and ethanol (2gm/kg/day) for 50 weeks. In the present study a total of 76 SHR at age of 5 weeks were employed and the experimental animals of each sex were further dividedinto the control (8), nicotine-treated (10), ethanol-treated (10) and nicotine plus ethanol-treated (10) groups. The systolic pressures of the male and female control groups were elevated from 120mmHg to 170mmHg in 5 weeks and 11 weeks, respectively and thereafter blood pressure of both groups started to rise gradually again. In both sexes systolic pressures were significantly higher in the nicotine-treated and nicotine plus ethanol-treated groups as compared with the control group. However, no significant difference was recognized between blood pressures of those two experimental groups. On the other hand, the body weight of the nicotine-treated and the nicotine plus ethanol-treated groups were significantly lower than that of the control group but no significant difference was observed between body weight of two experimental groups. As with blood pressure the body weight of SHR was not influenced by ethanol ingestion. The results of present study indicate that nicotine significantly elevates blood pressure of and retards growth of SHR and that ethanol does not appear to affect effects of nicotine on the blood pressure and body weight in hypertensive animals.
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Taurocholate가 자발성 및 담즙산유발 부정박동에 미치는 효과
최두석,고상돈,김기순 한양대학교 의과대학 1988 한양의대 학술지 Vol.8 No.1
Steroids have veen known to exert a number of pharmacological actions aside from its hormonal activities. Included are anesthetic, hemolytic, hemopoietic, hypocholesterolemic, antibacterial and antihypertensive activities. Bile acids, a derivatives of cholesterol, possess many of aforementioned properties of steriods. It has been reported that intravenous administration of bile acids results in bradycardia and hypotension and that bile acids, like digitails and sex steroids, can alter transmembrane potentials of cardiac cells. The present study was undertaken to explore arrhythmogenic and antiarrhythmic effect of bile acids and the results obtained were as follows; 1. No singnificant changes were observed in the action potential amplitude and rate of spontaneous firing of the sinoatrial node cell following superfusion with taurocholate (TCA, 0.05%). 2. The spontaneous arrhythmias were abolished by TCA in approximately 85% of experimental cases. 3. Arrhythmias were produced in approximately 30% of experimental cases following superfusion of sinus node cells with cholate (CA, 0.05%), glycocholate (GCA, 0.05%), and deoxycholate (DCA,0.025%) solutions, respectively. 4. When the sinoatrial node cells were superfused with TCA for 5 min, CA-induced arrhythmias were abolished in 8.0±1.5 min, on average. 5. TCA abolished GCA-and DCA-induced arrhythimas in 17.0±5.7 min, and 19.5±1.2 min, respectively. The results of present study indicate that some bile acids are arrhythmogenic while others antiarrhythmic.
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가토 심방 수축 및 동방결절세포의 활동전압에 미치는 Artemisia의 효과
양순재,김진혁,신홍기,김기순 한양대학교 의과대학 1990 한양의대 학술지 Vol.10 No.2
In order to explore electrophysiological effects of Artemisia mongolica Fischer on the cardiac functions, action potentials were recorded in teh isolated rabbit sinus node cells by means of the conventional microelectrode technique before and after superfusion with ethanol extract of Artemisia (AEE). Also studied were effects of AEE on the slow channel-mediated action potential (SAP) of the ventricular papillary muscle cells as well as on the atrial contractility in the rabbit heart. The results obtained were summerized as follows: 1) After superfusion with AEE(0.03, 0.05 & 0.08%) for 5min no significant changes were observed in overshoot potential (OS), maximum diastolic pptential (MDP) and action potential duration (APD 60) of the sinus node cells. 2) The AEE invariably decreased the rate of spontaneous firing (RSF) from teh sinus node cells. Generally the negative chronotropic effect of AEE was observed from 1 to 7 min after onset of superfusion. 3) Following superfusion with AEE amplitude of the SAP of teh ventricular papillary muscle decreased and the duration of SAP was shortened. 4) On the other hand AEE invariably decreased atrial contractility in a dose-dependent manner. 5) In the atrial segment treated separately with atropine, propranolol, quinidine and aminophylline, the negative inotropic effec of AEE were not altered. 6) The negative inotropic effect of AEE was not completely abolished by verapamil or ryanodine. 7) And AEE completely abolished atrial aftercontractions induced by electrical stimulation (1Hz-10msec-2T) of atrial miscle segment in the potassium-free Tyrode's solution. The results suggest that AEE decreases RSF of the sinus node cells as a result of reduced slow inward current (i Ca) and that the negative inotropic effect of AEE is associated with a decreased release of Ca²+ from the sarcoplasmic reticulum.
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Bovine bile에 의한 非痲醉動物의 心脈管系 反應
강돈규,고상돈,김기순 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.2
The present study was designed to investigate cardiovascular responses to intravenously administered bovine bile in unanesthetized cats. Also studied were effects of regitine, propranolol and atropine pretreatment on the cardiovascular responses following intravenous administration of bovine bile in conscious animals. The results obtained from the present study were as follows; 1. One minute after 30mg/kg bile administration the heart rate of anesthetized cats increased from 139.6±4.3/min to 157.4±7.6/min probably due to baroreceptor reflex. 2. In conscious cats heart rate decreased from 178.8±7.4/min to 146.0±10.1/min one minute after intravenous administration of bile and the decreased heart rate response persisted for 5 minutes thereafter. 3. Heart rate responses to bile were almost blocked following atropinization of conscious animals. 4. After intravenous administration of 30mg/kg bovine bile depressor responses were observed invariably in both anesthetized(79.2±3.8 mmHg) and unanesthetized cats (60.9±7.6 mmHg). In general depressor response to bile was more pronounced in anesthetized animals while the recovery from decreased blood pressure was more rapid in unanesthetized cats. 5. In conscious animals, depressor responses to bovine bile were partially blocked following regitine pretreatment, while no changes in depressor responses were noticed in either atropine or propranolol treated animals.
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