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      • KCI등재

        자궁경부 상피내 병변 환자에서 LEETZ 원추절제술 후 HPV DNA Test 추적 검사의 임상적 의의

        김미향,이태화,오영림,이천준,김원규 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

        Objective: This study was performed to investigate the clinical significance and timing of HPV test for follow up of patients after LEETZ treatment in CIN lesion Methods: From January 2005 to December 2008, 105 patients with CIN were treated with LLETZ at Kosin university gospel hospital, Busan, Korea. After LEETZ, HPV test and Pap smear were done after 3months. Every HPV typing was done by HPV DNA chip. Results: A total of 105 cases were enrolled in this study. There were 25 patients with CINⅠ, 38 with CINⅡ, 42 with CINⅢ. Mean age was 41.95 years (range, 23-71 years) at the time of LEETZ. Positive HPV DNA was found about 72.4% before LEETZ procedure and subtype 16 was the most common type (10.5%), follow by subtype 18 (6.6%) and subtype 58 (6.6%). During follow up after LEETZ, 65.6% had negative result after 3 month, 72.1% after 6 month, 73.9% after 9 month, 77.1% after 12 month, 79.2% after 15 month, 79.6% after 18 month, and 80.4% after 24 month. There were 2 cases of abnormal pap smear among persistent positive HPV DNA cases and no abnormal pap smear results in negative HPV DNA cases during follow up. Conclusion: Positive HPV DNA was found about 72.4% before LEETZ procedure and subtype 16 was the most common type (10.5%), follow by subtype 18 (6.6%) and subtype 58 (6.6%). We suggest that HPV DNA test is recommended per 6 Months, and close observation is recommended in persistent positive HPV DNA test cases.

      • 깻잎속의 重金屬 含量

        金美香,徐香順,劉賢玉,李承愛,鄭守然,趙桂賢 효성여자대학교 가정대학 학도호국단 1983 家政大論集 Vol.2 No.-

        공장폐수가 유입하는 금호강 하류의 하천부지에서 재배된 깻잎을 채취하여 일반영양성분 및 중금속 함량 등을 분석한 결과는 다음과 같다. 1. 깻잎속에는 수분 86.5%, 단백질 3.0%, 지질 0.6%, 당질 6.0%, 섬유질 2.6%, 회분 1.8%이고 Ca이 77mg%, P이 195mg%, Fe이 35mg%였다. 2. Cd함량은 0.05~0.46ppm로 평균 0.17ppm이였으며 Pb은 평균 0.66ppm이였다. This experiment was carried out to investigate the pollution state of heavy metal in vegetables. Perilla leave are used as the materials grown in the lower kyumho river into which polluted water from factories. The results were summarized as follow: Perilla leave contained 86.5% of water, 3% of protein, 0.6% of lipid, 6.0% of carbohydrate, 2.6% of fiber and 1.8% of ash. Minerals are composed of Ca 77mg%, P 195mg%, Fe 35mg%. The content of Cd was 0.05~0.46ppm, it's average was 0.17 ppm. The content of Pb was 0.23~0.90ppm, it's average was 0.66ppm.

      • 일 대학병원 임상 간호사의 가족지지와 성격, 삶의 질과의 관계연구

        김미향,서희숙,노영희 順天靑巖大學 1999 論文集-順天靑巖大學 Vol.23 No.-

        This descriptive correlational study was undertaken in order to investigate the relationship of family support and personality with quality of life of nurses in a general hospital and to provide basic data to help them improve a better quality of life. The subjects for this study were 26 nurses undergoing at C university hospital in K-city, from December, 1996 to January, 1997. The data were obtained using a convenience sampling technique. the tools used for this study were Ro's quality of life scale, Kang's family support scale and Wallston & others health locus of control scale. The collected data were analyzed by the SAS program using percentage, mean, standard deviation, pearson's correlation coefficients and stepwise multiple regression. The results were as follows: 1. The total average score of the quality of life of the subjects was 140.69(minimum score 49-maximum score 217), item mean score (range 1-5) was 2.99. The total average score of the family support of the subjects was 37.14(minimum score 23-maximum score 50), item mean score (range 1-5) was 3.38. The total average score of the health locus of control of the subjects was 36.29(minimum score 24-maximum score 50), item mean score (range 1-6) was 3.30. 2. There was significant positive correlation between the health locus of control and the quality of life (r=.2628, p<0.05). The result of the analysis of the relationship between the each factor in the quality of life and health locus of control were as follows: There were significant differences between the health locus of control and self-esteem factor (r= 0.3843, p<0.01), relationship with neighbors factor (r=0.4372, p<0.05). 3. There was a significant positive correlation between the family support and the quality of life(r=0.3417, p<0.0001). The result of the analysis of the relationship between the each factor in the quality of life and family support were as follows: there were significant differences between family support and emotional state factor(r=.1494, p<0.01), economic life factor (r=.3007, p<0.0001), self-esteem factor(r=.2900, p<0.0001), physical sate and function factor (r=.2232, p<0.0001), relationship with neighbors factor (r=.2724, p<0.0001), relationship with family factor (r=.3176, <0.0001). 4. By using stepwise multiple regression analysis, it was determined that the main influencing factors on the quality of life were family support(52%), health locus of control(21%). These two main variables explained 73% of variance in quality of life.

      • KCI등재후보

        골전이가 없는 자궁내막암 환자의 골밀도에 관한 후향적 연구

        김미향,김아리,김흥열,홍성남,이병익,이준희 대한골다공증학회 2013 Osteoporosis and Sarcopenia Vol.11 No.2

        Objectives: This retrospective study evaluated bone mineral density (BMD) in postmenopausal endometrial cancer patients without bone metastases. Materials and Methods: We retrospectively analyzed the BMD of spinal bone and the femur in 26 endometrial cancer patients and 32 control women. All of the patients and control women had reached their menopause. The control group was treated with benign uterine myoma whose age and body mass index are consistent with the case group. All BMD was measured by dual-energy X-ray absorptiometry. Results: Among the serum calcium concentrations and bone markers, alkaline phosphatase level was higher in endometrial cancer group than in controls. BMD of 4th lumbar vertebra was significantly lower in endometrial cancer patients (T-score: -0.63±0.77) than in controls (T-score: 0.88±1.83). Serum calcium concentration was higher in stage I patients (9.63±0.31 mg/dL) than that in stage II-III patients (9.26±0.31 mg/dL). BMD of 1st vertebra was lower in stage I patients (T-score: -1.80±0.97) than that in stage II-III patients (T-score: -0.60±0.95). Conclusions: We observed the increase of bone turnover along with the decrease of BMD in endometrial cancer which is estrogen dependent malignancy. Bone turnover increase and BMD decrease was even more distinct in early stage of endometrial cancer than later stages. A prospective randomized trial in large scale is warranted to elucidate the relation between the factors affecting bone density in endometrial cancer.

      • 쑥이 흰쥐의 Collagen 합성에 미치는 효과

        김미향 신라대학교 자연과학연구소 2004 自然科學論文集 Vol.13 No.-

        폐경을 앞둔 여성에게는 폐경을 전후하여 지속되는 골 손실 가속화 등의 문제점을 가지고 있다. 그러므로 본 연구에서는 인위적 폐경을 유발시킬 수 있는 난소 절제 쥐에서의 골손실의 유무를 결합조직 중의 collagen 함량 변화를 통하여 그 효과를 검토하였다. 생화학적 골 대사 지표인 혈 중 ALP 활성은 난소 절제로(OVX-control)로 인하여 증가하는 반면, 난소절제 후 쑥 추출물 투여(OVX-AP)로 혈 중 ALP 활성은 감소하는 경향을 보여 골 흡수를 저하시킬 수 있는 가능성을 나타내었다. 한편 난소 절제 후 쑥 추출물 투여에 의해 피부 조직과 골·연골 조직에서 collagen 함량이 증가하는 경향을 보였고, 쑥 추출물 투여군 모두에서 collagen 합성량이 유의적으로 증가하였다. 쑥 추출물이 에스트로겐 감소로 인한 collagen 합성저하를 회복시킨 본 실험 결과로 미루어보아 쑥 중의 phytoestrogen이 에스트로겐 유사효과를 나타냄을 알 수 있었고, 외인성 에스트로겐 투여로 인한 부작용을 줄여 줄 수 있을 것으로 기대된다. 이상과 같이 폐경기 여성에게 쑥 추출물의 섭취는 폐경으로 인한 장애를 감소시키기 위하여 에스트로겐의 장기간 복용에 의한 부작용을 쑥 중의 phytoestrogen이estrogen 대체 작용을 함으로써 그 부작용을 감소시켜 줄 것으로 사료되며, 이들의 구조 및 기전에 대해서는 앞으로 연구가 더 필요한 것으로 생각된다. The aim of this study was to evaluate the effects of Artemisia Princeps Var. Orientalis (AP) on the collagen content of the connective tissues in ovariectomized rats. From day 2 until day 37 after the ovariectomy, Sprague-Dawley female rats were randomly assigned to the following groups : sham-operated rats (Sham), ovariectomized control rats (OVX-control), and ovariectomized rats supplemented with the AP 50 mg/kg bw/day (OVX-AP50). The AP ethanol extracts were orally administrated 1 mL per day. The OVX rats were significantly heavier than the sham-operated rats at all time points, but supplementation with the AP extracts tended to gain weight less than OVX-control. Supplementation with the AP extracts prevented a decrease in the collagen level in bone and cartilage tissues. These results are consistent with the conclusions based on the estrogenic activities of AP. Therefore, it may be used to possibly improve the quality of life in menopausal women.

      • 도라지가 난소를 절제한 흰쥐의 혈 중 지질 함량 변화에 미치는 영향

        김미향,김원희,박미라,한희선,배송자 신라대학교 자연과학연구소 2003 自然科學論文集 Vol.11 No.-

        This study was designed to observe the effects of the feeding Platycodon grandiflorum A.DC(PG) extract on the improvement of the lipids on serum in ovariectomized rats. To investigate the effects of ethanol extract, Sprague-Dawley female rats were randomly assigned to groups as follows: Sham, OVX-control and ovariectomized rats supplemented with PG at 50㎎/㎏ bw/day. Body weight gain was not significantly different in groups. The levels of total cholestcrol was higher in ovaiectornized control rats than Sham-operated rats, but supplementation of PG ethanol extracts at 50mg/kg bw/day decreased the level of cholesterol in surum. These results might be expected that ethanol extract of PG is believed to be possible protective effects for the fatty serum increasing serum lipid.

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