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김상원,전미선,한세환,정용식,최진혁,강석윤,임현이,강승희 대한암학회 2017 Cancer Research and Treatment Vol.49 No.2
Purpose The effects of biological subtypes within breast cancer on prognosis are influenced by age at diagnosis. We investigated the association of young age with locoregional recurrence (LRR) between patients with luminal subtypes versus those with nonluminal subtypes. Materials and Methods Medical records of 524 breast cancer patients with positive lymph nodes between 1999 and 2010 were reviewed retrospectively. All patients received curative surgery and adjuvant chemotherapy based on contemporary guidelines. Radiation was delivered for patients who underwent breast conserving surgery or those who had four or more positive lymph nodes after mastectomy. Adjuvant hormone therapy was administered to 413 patients with positive hormone receptors according to their menstrual status. Results During median follow-up of 84 months, the 10-year locoregional recurrence-free survival rate (LRRFS) was 84.3% for all patients. Patients < 40 years showed significantly worse 10-year LRRFS than those 40 years (73.2% vs. 89.0%, respectively; p=0.01). The negative effect of young age on LRRFS was only observed in luminal subtypes (69.7% for < 40 years vs. 90.8% for 40 years; p < 0.01). Multivariate analysis using luminal subtypes 40 years as a reference revealed luminal subtypes < 40 years were significantly associated with increased risk of LRR (hazard ratio, 2.33; p < 0.01). Conclusion Young breast cancer patients with positive lymph nodes had a higher risk of LRR than those aged 40 years. This detrimental effect of young age on LRR was confined in luminal subtypes.
Review on Fabrication and Manipulation of Scaffold and Ciliary Microrobots
김상원,이승민,최홍수 한양대학교 의과대학 2016 Hanyang Medical Reviews Vol.36 No.4
Various microrobots are being studied for potential biomedical applications including targeted cell transportation, precise drug delivery, opening blocked blood vessels, micro-surgery, sensing, and scaffolding. Precise magnetic field control system is a coil system for wireless control of those microrobots for personalized and minimally invasive treatments. The microrobots for possible biomedical applications are fabricated by micro-electro-mechanical systems (MEMS) and nano-electro-mechanical systems (NEMS) technologies. In this review, fabrication technologies for scaffold and ciliary microrobots will be introduced and their control methods will be discussed. Various materials are being used for the fabrication of the microrobot such as SU-8, IP-Dip, IP-L, silicon, etc. The scaffold and ciliary microrobots are fabricated by SU-8, IPDip, and IP-L because these materials showed the maximum performance for threedimensional (3D) microrobots using a 3D laser lithography system. All or part of the structures are coated with nickel and titanium layers after fabrication of the structures for magnetic control and biocompatibility, respectively, of the microrobots.
김상원,서광철,이동건,이경우 해양환경안전학회 2017 海洋環境安全學會誌 Vol.23 No.3
In this research, we have calculated characteristics of wave-piercing high-speed planing hull, by using a RANS solver and overset grid method, for comparing with experimental measurements of that and simulating with several appendages, since the computed results of commercial CFD code look reasonable for the prediction of the performances of planing hulls on calm water in planing conditions. As a result, it is confirmed that the dynamic instability phenomena in pitch and heave motions (porpoising) occurred after a certain , and effectively suppressed using some of appendages, especially the 0.5L spray rail is suppressed to 24-55 % in the pitch motion and 33-55 % in the heave motion. In spray phenomenon, 1L hard chine suppress spray effectively and it is effective to set the angle of appendages to be less than 0° in order to suppress wave.