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      • HL-60 세포의 성장에 대한 제주자생 해조류의 효과

        김상철,박수영,김병석,강지훈,김세재 제주대학교 생명과학기술혁신센터 2002 제주생명과학연구 Vol.5 No.-

        The purpose of the present study is to examine the inhibitory effect of extracts of marine algae growing in Jeju on the growth of HL-60 leukemia cells. The effect was observed by measurement of metabolic activity and counting of viable cells. The methanol extracts on 36 species of marine algae growing in Jeju were screened for cytotoxic effect at the concentration of 100㎍/㎖. In results, the inhibitory effect on the growth was observed in the treatment of crude extracts on 7 species of marine algae. In particular, Dictyota dichotoma, Myelophycus simplex, Laurencia okamurae, Plocamium telfairiae, Petalonia binghamiae, Codium minus marketdly inhibited the growth of HL-60 cells.

      • KCI등재후보

        흰쥐에게 내독소의 비경구 투여가 혈청 및 간의 Glutathione S-transferase, Glutathione peroxidase 및 Glutathione reductase 활성 변동에 미치는 영향

        곽춘식,문교철,김상철 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.1

        The activities of the cytosolic, microsomal and mitochondrial glutatione S-tranferase (GST) which are detoxifying enzymes in thd liver were measured in order to evaluate the detoxifying ability of the liver to endotoxin. The activities of glutathione peroxidase(GSH-Px), glutathione reductase(GR) in the liver, GST and GR in the serum were also measured. For administration of endotoxin, a dose of 5㎎ of endotoxin (lipopolysaccharide E, coli O26: B6, from Sigma chemical company, USA) per kg of body weight was administered through a right external jugular vein. Then the rats were killed after 3, 8 and 24 hours of injection with endotoxin to measure the activities of the above enzymes in serum and their liver. The activities of the cytosokic and mocrosomal GST in the liver showed a significant decrease between 8 and 24 hours after endotoxin administration, but that of the motochondria showed no signifcant changes throughout the experiment. The activity of the GR in the liver showed a significant decrease at 24 hours after endotoxin adiministration. The activity of the GSH-Px in the liver showed a significant decrease at 8 hours after endotoxin administration. Serum GST and GR activitites showed a signifcant increase between 8 and 24 hours and between 3 and 24 hours after endotoxin administration respectively. According to the results, cytosolic GST and hepatic GR leak into the blood through the damaged membrane of hepatocyte. And it is suggested that the synthesis of the microsomal GST in the liver is decreased.

      • 장기적인 상치골 도뇨관 유치 환자에서 발생한 다발성 방광결석 (증례)

        김상철,문영태 중앙대학교 의과대학 의학연구소 2005 中央醫大誌 Vol.30 No.3·4

        Bladder stones usually occur in men older than 50 years and are often associated with bladder outlet obstruction, neurogenic bladder, chronic indwell urethral catheter, and foreign body. Common type of bladder stones in suprapubic cathererization are egg shell small calcification or single large stone. Common bladder stone composition is struvite or calcium-phosphate. We report a very rare case of bladder stone in patient with chronic suprapubic catheterization. This patient was a 54 years old male, admitted for the evaluation of frequency and suprapubic area pain. Bladder stones were detected by intravenousurography and cystography. Bladder stones were composed of calcium alone. Total 220 stone chips were removed by open cystolithotomy.

      • 韓國 電子産業의 品質管理에 관한 考察

        金相哲 배화여자대학 1983 培花論叢 Vol.2 No.-

        1. The purpose of the study The Korean electronic industry has played a major role since its introduction in the industrial modernization of our Country. It has been leading the exporting industry of this Country. Therefore it makes it necessary for us to re-evaluate the fundamental structure of the korean electronic industry in order to compete in the international market. It is necemary for us to develop and stress new technical and managerial skills and renew a promtion on quality control. Quality control consciousness has in creased greatly due to improvement of operatinal facilities. The expansion of quality test facilities the intensification of educafional training on quality Control for the emploees but at present it cannot equal the quality of advanced nation due to their prolonged use of quality control measures. The author of this thesis attempted to establish the hypothesis that problems which encompars the nationality of the korean quality control system now practisled by the korean electronic manufacturs. There in lies such factors as lack of capital and skill, lack of top managers understanding on quality control, disputes with in the organization of the korean electronic industry, poor motivation of employees etc. It has been attemped to further explore the hypothesis to examine the probloms of quality control and to suggest and recommend practical methods for economic and scientific introduction of quality cotral measures in the Korean electronic industry. 2. The method of the study A questionaire was fabricated to facilitate a survey through interviews with manager at company level for a specific care study and analysis of findigs from the survey reflected present conditions prevailing throughout the Korean electronic industry. 3. The Corntent of the thesis This research is consist of four chapters. Chapter l introduced the purpose, procedure, and scope of research. Chapter 2. is set forth a theoretical background of quality control's application in electronic industry. Chapter 3 explained the precent state of the quality control in electronic industry, and analyzed the actual proof method of the actual condition's analysis of the quality control in the manufacturing plant, and proposed the problem field of the quality control and its improvable course. Chapter 4 Summarized the conclusion.

      • KCI우수등재
      • KCI등재

        鎭痛醫療 事故의 現況과 問題點

        金相哲 大韓法醫學會 1990 대한법의학회지 Vol.14 No.2

        It is easy for physicians to evaluate objectively the mode of pains occuring in various kinds of diseases. In the course of medical care, pain should be comprehensively estimated by means of all information obtained from patients and medical records including family history, patient's past and present history, physical examination and laboratory data. After getting all information about pains from patient, medical practitioners should try analgesic trial to relieve the pain, but those who participate in analgesic medical care have to be careful of prescribing narcotic analgesics, especially such as morphine and its analogues, because of dependency and unpredictable risks. Here is described the current status and problems related to incidents occuring in analgesic trials.

      • 線型模型에 의한 統制시스템의 設計

        金相哲 圓光大學校大學院 1985 學位論叢 Vol.15 No.-

        The purpose of this study is to provide a new method of setting standards for control system and is confined to the estimation of a cost function for the operations performed by several decentralized units in an organization. Especially a uniform cost control system is applicable to the operationally homogeneous units. In management literature, 'control' is defined as a process that glides activities toward an established gool or plan. The concept 'control' can be further explained as follows ; a. The first phase is to set standards that represent the desired performance or to adopt an operation plan. b. The second phase is to compare actual results with standards or the plan. c. The third phase is to analyze the operating variance planning and corrective action. The standards may be classified into (i) the attainable ideal standards representing the performance levels that are considered highly or most efficient under normal conditions, (ii) the attainable normal standards representing the average performance levels under normal operating conditions over a period of time, and (iii) the theoretical ideal standards represennting the best performance possible levels theoretically. From this point of view, we may regard the empirically estimated maximum output for a given combination of inputs in a production system as the attainable ideal standard. For the estimation of the attainable ideal standards, the concept of frontier cost function is to be reviewed first of all. The modeling of production activities has long occupied a central role in econometric research, especially in searching for statistical estimators of the theoretical frame and in providing a stimulus for the development of new methods. Traditionally, accounting has been the major source of management information and managerial accounting, in particular, has provided data for the planning, control, and internal performance evaluation. The goal of this study is to contribute to cost accounting system in providing more useful information in the planning and control process of management. The study is attempted to expand the models for analysis of cost behavior based on a multiple regression model and a linear programming model. It is formulated to estimate the frontier cost function which reflects the best operation possible in the system, which the multiple regression model yields the "average" cost function during a time period throughout the units. The frontier cost function can be used to yield the "target" cost which is accomplishable under the given conditions in the system. The ANOCOVA model includes the cost efficiency parameter, Ai, to reflect the difference in the cost efficiency among the units. The ANOCOVA model improves the estimation of the average cost function by estimating the specification bias which stems from excluding the cost efficiency parameter the multipe regression model. Accarding to Johnston the ANOCOVA also utilizes "The best source of information for the short-run analysis" of cost behavior with the pooling data. The cost function from the ANOCOV A model yields the "average" cost of operation in each unit under the normal operating conditions. Once an operation results in an actual cost, we can analyze the performance of each unit by comparing ; (1) The target cost. (by L. P. model) (2) The average cost for the unit. (by ANOCOVA model). (3) The actual cost. This is another version of the traditional cost accounting variance analysis but the above method is unique in the sense that the target cost and the expected average cost for the unit are realistic estimates based on the analysis of the actual capabilities of the system under the given conditions. In the empirical study, the data obtained from the 21 branches of the A bank in seoul is used to estimate the parameter of cost function by linear programming model for a firm as the attainable ideal standard. And using classical linear regression analysis, the attainable normal standard is estimated and compared with the frontier. In order to continue this study, we should find performance variables and influencing factors of firm performance efficiency and time performance efficiency. If we are able to find the performance variables, from the analysis. we can achieve the good theory to find the efficiency variables.

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