Antitumor and Antiinflammatory Constituents from Celtis sinensis

김대근,Jong Pil Lim,Jin Wook Kim,박희욱,은재순 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.1

Eight compounds were isolated from the methanolic extract of the twigs of Celtis sinensis through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as two triterpenoids, germanicol and epifriedelanol, two amide compounds, trans-N-caffeoyltyramine and cis-N-coumaroyltyramine, two lignan glycoside, pinoresinol glycoside and pinoresinol rutinoside, and two steroids by spectroscopic analysis.

근로자 파견 법리의 불법구조와 분석 - 파견과 도급의 구별 기준 정립을 위한 시론

김대근 노동법이론실무학회 2018 노동법포럼 Vol.- No.24

To manage an efficient business organization as well as save production and labor cost, businesses largely rely on external labor. External labor is mainly used in the form of in-house subcontracting where a client contractor (hereinafter “client”) facilitates workers of another prime contractor (hereinafter “contractor”) to work at the client’s workplace. The problem, however, is not in contracting out and making use of external labor. The problem is that even though businesses hire workers with rights protected by the Temporary Work Act or the Fixed-term Act, they disguise these workers as contract workers or entrusted workers to avoid being subject to related labor laws. Disguised subcontracting not only raises problems in the context of labor law, it also raises inequity issues. As disguised contracting is subject to criminal punishment under the Temporary Work Act, it is important to distinguish contract work and temporary work prior to punishing the user company. Unfortunately, the current law does not clearly distinguish the difference between contract work and temporary work. To be sure, progress has been made regarding this issue. As a result, many cases were accumulated and composed together to establish legal principles that provide standards to differentiate contract work and temporary work. In addition, in 2015, the Supreme Court provided a general standard using various cases including the Hyundai Motor case. Despite the provision of the general standard, however, a more explicit standard to differentiate the two works is required for the following reasons: first, the general standard is a mere group of signs drawn from previous cases; second, the general standard does not fully reflect the distinctive features of each respective type of in-house subcontracting; and third, the process of making a comprehensive judgement after individual judgement is very unclear and as a result, despite the Supreme Court’s decision in 2015, judgements among lower courts have remained inconsistent. Also, the Korean government has been making efforts to address the problem of disguised contracting on industrial sites by referring to the Guidelines on the Judging Standards of Temporary Placement of Workers (April 19, 2007) as outlined in the Reference to Classify Temporary and Contract Work. However, these guidelines do not reflect the general standard set out by the Supreme Court in 2015. This type of miscommunication can hinder the predictability of judgements distinguishing temporary and contract work, and eventually weaken the public’s trust in law. It can also raise doubts on the effect of measures taken to prevent further disguised contracting. Furthermore, it is important to note that the Supreme Court focused on the status of the worker when establishing the classifying standard. Thus, further discussion is necessary to determine the suitability of the standard when applying it to interpret criminal elements related to the violation of the Temporary Work Act. Based on such research, this article concludes that the current Temporary Work Act should be at the center of establishing the classifying standard. This article also proposes a new standard to distinguish temporary and contract work focusing on the requirements of temporary work under the current Temporary Work Act, as well as the specific contents of the authority to conduct which was developed through the legal principle set out by the Supreme Court.

강하식탑승장치(MES) 강하실험을 통한 선박구명설비기준에의 제안

김대근,이은수 해양환경안전학회 2019 해양환경안전학회 학술발표대회 논문집 Vol.2019 No.11

Trends in the Diagnosis of Osteoporosis in Patients with Distal Radius Fractures Based on a National Claims Database

김대근,서기원,남혜원 대한골대사학회 2019 대한골대사학회지 Vol.26 No.4

Background: A history of osteoporotic fractures is strongly associated with the subsequent osteoporotic fractures. To prevent subsequent fractures, the diagnosis and treatment of osteoporosis following osteoporotic fractures are very important. A distal radius fracture (DRF) is the second most common type of osteoporotic fracture in South Korea. We analyzed the rate of osteoporosis diagnosis within 6 months post-DRF. Methods: We used data from the Korean Health Insurance Review and Assessment Service nationwide claims database from 2010 to 2016. International Classification of Diseases, 10th revision codes and procedures codes were used to identify patients aged over 50 years with newly diagnosed DRFs; the osteoporosis assessments of these patients were then analyzed. We used Cochran-Armitage trend test to examine trends in osteoporosis diagnosis. Results: A search of database identified 77,209 DRFs in patient aged above 50 years of age from 2011 to 2016. Among these patients, only 19,305 (25.0%) underwent diagnostic examination for osteoporosis. The number of osteoporosis examinations increased slightly, but not significantly, every year (P=0.061). Conclusions: Clinicians who treat DRFs shoulder also evaluated patients for osteoporosis after DRFs.

배 유래 추출물의 추출 및 건조 공정에 따른 알부틴 함량 비교 분석

김대근,이종환,이일남,윤제정 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1

나주 산 배의 착즙 후 부산물을 이용하여 추출 및 제형 과정에 따른 성분의 함량을 분석 했다. 배 부산물의 성분분석으로 향기성분 분석에는 GC-MS를 사용하였고, 활성성분의 분석은 HPLC/MS/MS를 이용하여 MRM법으로 분석하였다. 활성을 가지는 성분으로는 알부틴, 카페인산이 함유되어 있다. 시료의 제조로 나주 배 부산물을 동결건조 및 열풍건조하여 상온에서 추출한 다음 Brix% 농도를 조절하고 당 성분 때문에 셀룰로오스계열의 물질을 첨가하여 파우더로 제형하였다. 실험결과 열풍건조 후 제형까지 마친 시료의 경우 20 Brix%, 40 Brix%, 60 Brix%에서 알부틴의 함량은 배 부산물의 1 g 무게당 2.213 ug, 1.703 ug, 1.668 ug 으로 Brix% 농도가 높아갈수록 알부틴의 함량이 줄어드는 특이점이 결과로 도출되었고, 동결건조 후 제형까지 마친 시료의 경우에는 2.3 Brix% 농도로 제조된 경우에도 배 부산물의 1 g의 무게당 알부틴의 함량이 4.144 ug으로 높게 검출되었다. 기본적으로 배 유래 부산물의 추출시에 이산화탄소 가스를 이용한 초임계 유체 추출보다 물 추출 및 메탄올 추출이 알부틴 및 카페인산의 성분 추출에 더욱 많은 양의 성분이 추출됨을 확인하였다.

수리특성곡선을 이용한 유향측정 자료의 보정

김대근 대불대학교 2003 論文集 Vol.9 No.1

In order to modify incorrect flow dara in the sewage system, the method using the stage-discharge relation and hydraulic characteristic curve of swer pipe aer applied. The modified data were verified with field measured data and the infiltration analysis using the modified data was carried out. When flowrate were measure using the flow-meter in fair weather, the stage data were comparatively consistent but velocity data were very poor for the most part. Therefore, it was recommended that sewage floweate variation characteristic curve and infiltration were computed using the modified data on the basis of stage data. Especially, in the case of using the hydraulic characteristic curve, extrapolation results of the rainy season flowrate using regression curve on the basis of the data in fair weather were also reasonable.

수렴형 선상유역에서 운동파의 수치해 및 해석해

김대근 조선대학교 공학기술연구원 2018 공학기술논문지 Vol.11 No.1

For kinematic wave flood routing in a converging fan-shaped basin, a storage equation was derived in the present study with its analytical solution. The derived storage equation was then discretized as a finite difference equation. A numerical solution of the discretized, nonlinear finite difference equation was obtained by the Newton-Raphson method. The comparison of the analytical solution derived in the present study with the numerical solution showed that the analytical solution may overcome the shortcomings of previous results where the flood wave rising curve rose more slowly than the actual rising. In addition, the analytical solution derived in the present study was used to analyze the sensitivity of the variables determining the basin roughness, basin slope, and basin shape, such as the coefficient , with respect to the outflow hydrograph. The sensitivity analysis results showed that the rising part of the hydrograph rose more slowly when the roughness coefficient was larger and the basin slope was slower. The results also showed that the peak discharge decreased and the concentration time also decreased as the coefficient  was increased.

나눔의 이름으로 배움을 얻는 봉사

김대근 열린전북 2007 열린전북 Vol.2007 No.9

바이오필터의 운전효율 안정화를 위한 전처리장치 개발

김대근,George A. Sorial 한국대기환경학회 2007 한국대기환경학회 학술대회논문집 Vol.- No.-

가을강아지풀의 C-Glycosylflavone 성분

김대근 한국생약학회 2016 생약학회지 Vol.47 No.3

Four flavone compounds were isolated from the whole plants of Setaria faberi Herrmann (Gramineae) through repeated column chromatography. Their chemical structures were elucidated as tricin (1), and three C-glycosylflavone, 2"-O-rhamnosylvitexin (2), 2"-O-rhamnosylscoparin (3), and 2"-O-rhamnosylorientin (4), respectively, by spectroscopic analysis. These compounds were isolated for the first time from this plant.