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Phenacetin Microcapsule에 있어서 可笑化時間이 溶出率 및 血中濃度에 미치는 影響에 關한 硏究
김좌진,고건일,김재백 圓光大學校 藥品硏究所 1986 藥品硏究所報 Vol.1 No.1
Microencapsulated Phenacetin were prepared by coacervation of aqueous Cellulose Acetate Phthalate(C.A.P) solution. The C.A.P. shells are plasticized by imbibition with 5% Glycerol solution. As a result, piasticized microencapsulated phenacetin was correlated between dissolution rate and plasticizing time in microcapsule. The dissolution rate was increasing of plasticized time. In Rabbit oral administration, the absorption of Phenacetin was correlated with plasticizing time, It is suggested that plasticized time could be controlled plasma level of Phenacetin
NLRP3 Inflammasome and Host Protection against Bacterial Infection
김좌진,조은경 대한의학회 2013 Journal of Korean medical science Vol.28 No.10
The inflammasome is a multi-protein complex that induces maturation of inflammatory cytokines interleukin (IL)-1β and IL-18 through activation of caspase-1. Several nucleotide binding oligomerization domain-like receptor family members, including NLRP3, recognize unique microbial and danger components and play a central role in inflammasome activation. The NLRP3 inflammasome is critical for maintenance of homeostasis against pathogenic infections. However, inflammasome activation acts as a double-edged sword for various bacterial infections. When the IL-1 family of cytokines is secreted excessively, they cause tissue damage and extensive inflammatory responses that are potentially hazardous for the host. Emerging evidence has shown that diverse bacterial pathogens or their components negatively regulate inflammasome activation to escape the immune response. In this review, we discuss the current knowledge of the roles and regulation of the NLRP3 inflammasome during bacterial infections. Activation and regulation of the NLRP3 inflammasome should be tightly controlled to prevent virulence and pathology during infections. Understanding the roles and regulatory mechanisms of the NLRP3 inflammasome is essential for developing potential treatment approaches against pathogenic infections.
영지다당체의 실험적 간경화에 대한 섬유화 억제효과에 대한 연구
김좌진,김재백,고건일,손동환 圓光大學校 藥品硏究所 1996 藥品硏究所報 Vol.11 No.1
This study was carried out to investigate the effects of the water soluble fraction and the ethanol soluble fraction of polysaccharide extracted from Ganoderma lucidum. The experimental hepatic cirrhosis was induced by bile duct ligation/scission (BDL/S) in rats. BDL/S rats in each group were dosed 5 mg/rat/day of the ethanol soluble polysaccharide extracted from Ganoderma lucidum and were dosed 0.5, 2.0, 5.0 or 10 mg/rat/day of the water soluble polysaccharide orally for 4 weeks after the operation. Antifibrotic effects were evaluated by serum biochemical values, hydroxyproline contents in liver, and light microscopical histology of liver. In ethanol soluble polysaccharide extracted from Ganoderma lucidum, the result obtained were as follows; Hydroxyproline and PIlIP contents in liver of 5mg/kg treated group were significantly reduced. In serum test ALT AST values were rather increased. In water soluble polysaccharide extracted from Ganoderma lucidum, the results obtained were as follows; 1) Hydroxyproline contents in liver of 2.0 and 5.0 mg/kg treated group were significantly reduced in dose dependent manner. 2) In serum test, ALT, AST, ALP values in polysaccharide group were lower than BDL/S control group. 3) The hepatic damage such as hepatocellular inflammation, bile duct proliferation and fibrosis was less severe in the livers of 2.0 and 5.0 mg/kg polysaccharide treated rats than BDL/S control groups. These results suggest water soluble polysaccharides from Ganoderma lucidum had the antifibrotic effect on liver cirrhosis induced by BDL/S.
High Omega-3 Polyunsaturated Fatty Acids in fat-1 Mice Reduce Inflammatory Pain
장은지,김좌진,신나라,Yuhua Yin,Yongshan Nan,Yinshi Xu,홍진표,Tzung Min Hsu,정우석,고영권,이원형,임규,김동운,이선열 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.6
Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs), such as α-linolenic and linoleic acids, are essential fatty acids in mammals, because they cannot be synthesized de novo. However, fat-1 transgenic mice can synthesize omega-3 PUFAs from omega-6 PUFAs without dietary supplementation of omega-3, leading to abundant omega-3 PUFA accumulation in various tissues. In this study, we used fat-1 transgenic mice to investigate the role of omega-3 PUFAs in response to inflammatory pain. A high omega-3 PUFA tissue content attenuated formalin-induced pain sensitivity, microglial activation, inducible nitric oxide synthase expression, and the phosphorylation of NR2B, a subunit of the N-methyl-d-aspartate (NMDA) receptor. Our findings suggest that elevated omega-3 PUFA levels inhibit NMDA receptor activity in the spinal dorsal horn and modulate inflammatory pain transmission by regulating signal transmission at the spinal dorsal horn, leading to the attenuation of chemically induced inflammatory pain.
An NMR Study on Internal Rotation of CH3 Group in 1,1,1-Trichloroethane
남궁현,김좌진,이조웅 한국자기공명학회 2000 Journal of the Korean Magnetic Resonance Society Vol.4 No.1
Coupled carbon-13 relaxation study of 1,1,1-trichloroethane dissolved in DMSO has been performed to gain some crucial insight into the dynamics of methyl group in this compound. For this purpose the relaxation behaviors of several observable magnetization modes for CH3 spin system generated by various perturbing pulse sequences have been carefully investigated and various dipolar spectral densities were estimated by nonlinear numerical fittings of the observed data with the relaxation curves, which were then employed to determine the three principal values for the diffusion tensor for end-over-end molecular rotation as well as internal rotational parameters of methyl group. In this process we could uniquely determine two correlation times and which give valuable information on internal rotor dynamics and thus obtained data were interpreted on the basis of various proposed models for internal rotation. compound undergoes three-fold jumps at 25°. The fact that the ratio / is close to 1.0 may be interpreted as indicating that methyl group in this C. 영어논문
학교건물의 공기질 개선을 위한 환기시스템 적용에 관한 연구
안철린(Ahn, Chul-Lin),김좌진(Kim, Jwa-Jin),금종수(Kum, Jong-Soo),박효순(Park, Hyo-Soon) 한국교육시설학회 2004 敎育施設 Vol.11 No.2
The purpose of this study concerns the improvement of air quality in school classrooms. Polluted indoor air is improved by efficient ventilation systems. So it is important to measure the amount of ventilation needed in classrooms. First, the amount of natural ventilation were measured through a tracer gas method. And we have established a heat recovery ventilation system from 4 cases of airflow in classrooms, and we have measured the change of density. According to air quality measurements in the classrooms, the density of is well above environmental standards which are acceptable. When the amount of ventilated airflow increases, indoor air quality is improved. It is surveyed that the most suitable amount of external inducted air is 770 CMH to satisfy less than 1,000 ppm in classrooms. For improvement of air quality in classrooms, we must consider a suitable ventilation plan and installation of ventilation systems when constructing school buildings.