고혈압성 흰쥐(Spontaneous Hypertensive Rat)에서 Nifedipine투여가 Mixed-Function Oxidase와 Lipid Peroxidation에 미치는 영향

배영숙,홍영숙,김환권,김이우 中央醫學社 1989 中央醫學 Vol.54 No.10

The effect of intraperitonelly administered nifedipine, an antiphypertensive medication on the mixed-function oxidase system components, such as cytochrome P-450, cytochrome b5, NADPH- and NADH-cytochrome C reductause, p-nitroanisole-O-demethylase, and the formation of lipid peroxide and UDP-glucuronosyltransferase in the spontaneous hypertensive rat hepatic microsomes were investigated. The result is as follows: 1. After 3-7 day of nifedipine injection bidaily, the contents of cytochrome P-450 and b5 were slightly increased and after 4 weeks of nifedipine injection bidaily, the contents of cytochrome P-450 and b5 were increased significantly. 2. After 2 and 4 weeks of nifedipine injection bidaily, the activities of NADPH- and NADH-cytochrome C reductase were increased significantly. 3. After 2 and 4 weeks nifedipine injection bidaily, the activities of monooxygenase, p-nitroanisole-O-demethylase were increased significantly. 4. The formation of lipid peroxide did not change for 4 weeks injection bidaily. 5. After 2 and 4 weeks of nifedipine injection bidnily, the activity of UDP-glucuronosyltransferase was increased markedly.

가토에서 TRH로 야기된 장내용물 이동항진에 대한 Naloxone 및 Naltrexone의 봉쇄작용

배영숙 梨花女子大學校 醫科大學 醫科學硏究所 1984 EMJ (Ewha medical journal) Vol.7 No.4

Thyrotropin releasing hormore(TRH) administered intracerebroventricularly (i.c.v) in microgram quantities to anesthetized rabbits, produces marked stimulation of colonic motility, transit and fluid accumulation. These effects depend on an intact vagal system. Atropine blocks hypermoti-lity but not the increased intestinal transit and fluid accumulation. The latter ef-fects are antagonized by antiserotonin compounds. In this study, we found that pretreatment of rabbits with naloxone(2.5㎎/㎏) or naltrexone(1.0㎎/㎏) attenuated or blocked the TRH-induced colonic transit and increase in luminal fluid, but not the hypermotility. In this respect the narcotic antagonist effects resemble those produce by the antiserotonine compounds or opiate agonists.

시각과 청각되먹임이 통증감소에 미치는 영향

배영숙,김순희,민경옥,Bae, Young-Sook,Kim, Soon-Hoe,Min, Kyung-Ok 대한물리치료과학회 2002 대한물리치료과학회지 Vol.9 No.1

This study set out to investigate what kind of effects the consistent visual stimuli and verbal and non verbal auditory stimuli have on pain alleviation, as well as to see the influence of joint application of visual and auditory stimuli at the same time on pain alleviation, according to lightness of 50lux and 200lux, ultimately providing basic data in setting up an environment in case of treating pain. The subject were comprised of 30 male and female adults with pain in the neck and back area. The subject were treated in their pain area with Transcutaneous Electrical Nerve Stimulator(TENS) 100HZ for 20 minutes in the research set where each visual, auditory, and joint visual and auditory stimuli was given. For analysis methods, Visual Analogue Scale(VAS) and McGill Pain Questionnaire were adopted to see the changes before and after treatment, and the electrocardiogram, systolic and diastolic pressure, number of heart rate and breathing frequence and endorphin were compared and analyzed using the Wilcoxon singed-rank test. And The Kreskal-walllis test was used to compare the two subgroups from each group. Wilcoxon singed-rank test and the Kreskal-walllis test was used to compare the two subgroups from each group. The results were as follows: 1. The group of 50lux and 200lux were compared given varying degrees of visual stimuli. The group of 200lux showed more reduction in pain points, average systolic and diastolic pressure and average endorphin. 2. The group of verbal and non verbal were compared given varying degrees of auditory stimuli. The group of non-verbal showed more reduction in average systolic and diastolic pressure. 3. The group of 200lux+verbal and 200lux+non verbal were compared given varying degrees of joint visual and auditory stimuli. There was found a statistical significance(p<0.05) in endorphin between the two groups, with more endorphin reduction for 200lux+non verbal group. And there was a statistically significant reduction in VAS and McGill before and after the treatment between the two groups.

개심술을 받은 환자에서 적용된 간호진단 분석

배영숙 성인간호학회 1994 성인간호학회지 Vol.6 No.1

This research was done for the improvement of practical appliance of Ng diagnosis and for the elevation of nursing quality(level). Ng students of the fourth grade of K university which is in Taegu cared for patients who were admitted for open heart surgery in the ICU. They practiced form march 5, 1992 to July 2, 1993, each for 3 weeks. After their practice, they reported on 31 cases which had a total of 204 Ng diagnoses. I analized the Ng diagnoses with 170 diagnoses used by NANDA and 34 diagnosis by non-NANDA through comparison diagnoses from NANDA. The general characteristics of the patients are as follow : by sex, men were 6 cases (19.4%) and women were 25 cases (80.6%). In age, 16∼39 were 9 cases (29.0%), 40∼49 were 11 cases (35.5%), and over 50 were 11 cases (35.5%). In diagnosis of the patients, AR & MR were 7 cases (22.6%), ASD were 2 cases (6.5%), MR were cases (54.8%), PS was 1 case (3.26%), Angina Pectoris (CABG) were 4 cases (12.9%). Ng students used all 204 Ng diagnoses. They used 170 NANDA in them, which means that one person used about 5.5 of NANDA's diagnoses. The diagnoses other than NANDA were 34(16.7%), which means one person used about 1.1 of non- NANDA's diagnoses. We think from this that non- NANDA's students do not have enough knowledge and experience in using diagnoses, and they tend to use their own diagnoses. All used NANDA's was 25 diagnoses in which the most popular diagnoses were ineffective air way clearance (48.4%), mobility, physical impairment, ineffective bleeding patterns, knowledge deficit, all of them were 41.9% in 31 cases. Kang showed self care deficit (27.7%), skin integrity (23.4%), tissue perfusion, alteration cerebral area (16.4%), and high risk for infection (0.6%), in her diagnosis analysis research of brain disease patients. Park(1987) showed the representative diagnosis of high risk for injury, altered nutrition less than body requirements, knowledge deficit, sleep pattern disturbance, knowledge deficit, sleep pattern disturbance, and fluid volume excess, in her evaluations, of the original and revelational research rate of five diagnosis in patients with CAAH or CAVH. When we consider the specifics of each patient we can determine how the Ng assessment reveals that patients problems differ according to their disease. Signs and symptoms are one thing, and nursing requests are another. The nursing diagnosis of 170 NANDAs according to age has 7.2 diagnoses per person in 40 through 49 years old. 5.5 diagnoses in those over 50. It is much more than 3.3 diagnoses in 16 through 39. The number of nursing diagnoses as medical diagnoses didn't have difference, in those 5.0 through 7.0. Nursing diagnoses as of the day of admission in the ICU was 6.6 diagnoses of NANDA person for 3 through 5 days. 31 patients were in the ICU after having open heart surgery, and it seems that nursing problems and requirements of patients were not different. The specific response-formal analysis in exchanging (52.0%), moving (12.0%), feeling (12.0%), knowing (8.0%) in 25 diagnoses, is similar with the research of Park, Lee (1989) who showed exchanging (43.7%), feeling (23.5%), moving (19.3%), perceiving (4.0%), knowing (3.8%). The related factors of ineffective air was clearance were painkillers or sedatives (53.3%), and secretion(40.0%). Using painkillers and sedatives I think must result in energy decrease or fatigue. The related factors of impaired physical mobility were due to pain and discomfort in NANDA. And attachment of instrument (30.8%) cannot be used as the related factor. The related factors of ineffective breathing pattern, heart failure (23.1%) can't be used as medical diagnoses, so it must be changed to energy decrease or fatigue. As the related factor of knowledge deficit, there was a perceiving deficit (53.8%) which is represented as a knowledge deficit in NANDA and which I think is more familiar using the word confusion. The relation of anxiety was in connection with the change of health situation (81.8%), and economical problem (9.1%). Another related factor is operation (9.1%) which doesn't belong to NANDA. Operation itself is the change of health situation which must be the related factor.

척추감압치료가 특발성 척추측만증에 미치는 효과

배영숙,엄기매,최원호 한국운동재활학회 2009 JER Vol.5 No.2

茵蔯蒿의 膽汁分泌 機轉에 관하여

裵玲淑,洪永淑 梨花女子大學校 韓國生活科學硏究院 1980 韓國生活科學硏究院 論叢 Vol.25 No.-

漢方 및 민간에서 흔히 黃疸 치료에 사용하는 菌蔯蒿를 家兎에 투여하여 다음과 같은 결론을 얻었다. 1) 담즙 분비량은 菌蔯蒿 투여군에서 대조군에 비해 별다른 변화가 없었다. 2) 담즙 biliverdin은 菌蔯蒿 투여군에서 상당히 증가된 치를 나타내었다. 3) 담즙 cholate 치는 菌蔯蒿 투여군이나 대조군이 비슷하였다. 4) 담즙 cholesterol 치는 菌蔯蒿 투여군이 대조군에 비해 별 변화가 없었다. 5) 간장 microsome 內 cytochrome p-450은 菌蔯蒿 투여군에서 상당히 높은 치를 나타냄을 볼 수 있었다. Artemisia was used as folk medicine for hyperbilirubinemia. Kiku Tanni(1968) claimed that administration of Artemisia in patient with acute hepatitis, significantly lowered the bilirubin index, S.G.O.T and S.G.P.T. And Yokawa(1929) reported that I.V injection of Artemisia in rabbits revealed the increased volume of biliary juice. Therefore, ws decided to determine the mechamism of biliary excretion atter I.V. injection of Artemisia in rabbit. The results of this experiment were as follows:, 1. After I.V injection of Artemisia in rabbits, biliary juice volume was not increased than that of control group. 2. Biliverdin concentration in bile juice of rabbits treated with Artemisia significantly increased than that of control group. 3. Cholate and cholesterol concentration in bile juice of rabbit treated with artemisia was not increased than those of control group. 4. Liver microsomal cytochrome P-450 was increased significantly following Artenisia treat-ment.

지연성 근육통의 통증감소와 관절 가동범위 회복에 경피 신경전기자극 주파수의 효과비교

배영숙,엄기매 한국스포츠리서치 2006 한국 스포츠 리서치 Vol.17 No.6

노인이 지각한 사회적 지지와 자아통합감에 관한 연구

배영숙 성인간호학회 1993 성인간호학회지 Vol.5 No.1

This study was done to know the relationship between perceived social support and ego integrity in the Elderly. The subjects consisted of 173 active and communicable persons aged over 65 living in Kwang Ju. Data was collected through interview with questionnaire from July 10 to 29, 1992. The questionnaires were the Scale of Social Support and the Health Assessment Scale for the Elderly. Analysis of data were done by percentage, t-test, ANOVA, and Person Correlation. The results were summarized as follows: 1. The average score of ego integrity in the elderly were 93.9 of total 155, and related to religion(F=8.08, P<.01), educational level(F=5.90, P<.001), income(F=5.58, P<.001), perceived health status(F=6.50, P<.001), number of persons living with(F=6.64, P<.001), people who was living with(F=6.62, P<.01), social supporter(F=2.73, P<.001), satisfaction with social support(F=4.95, P<.001), frequency of social support(F=5.86, P<.001) and similarity of life style to supporter(F=6.64, P<.001). 2. The average score of perceived social support in the elderly was 139.5 of total 200. The subjects perceived significantly high social support in situation of living with their spouse(F=13.91, P<.001), having any educational level(F=2.78, P<.05), having only one or two family(F=7.42, P<.001) and spouse who was living with(F=5.79, P<.01). 3. Social support and ego integrity were positively related(r=.57979, P<.001). The more elderlies perceived social support, the higher the elderlies' ego integrity.

흰쥐에서 Handling과 주사에 의한 Stress로 야기된 고체온에 관하여

배영숙 梨花女子大學校 醫科大學 醫科學硏究所 1984 EMJ (Ewha medical journal) Vol.7 No.4

Experimental handling and colonic temperature measurement have been shown to cause stress and induce a long lasting rise in colonic temperature in the rat. Injection is also a type of stress to induce hyperthermia in the rats. In the pr-esent study, no difference was found between injection group and simple handling group.

측뇌실내 PCPA와 5,7-DHT 투여가 흰쥐 체온에 미치는 영향

배영숙,박혜영 梨花女子大學校 醫科大學 醫科學硏究所 1993 EMJ (Ewha medical journal) Vol.16 No.4

Simonic(1988) have investigated that hypothermic effect of oholinornimetics is mediated through an activation of muscarine cholinergic receptors. And also, Yamada(1987) injected trytamine into the lateral cerebroventricle in mice and observed hypothermic through 5-HT_1 receptor. We have previously reported that PCPA(a serotonin depletor), has reduced 5-HT contentsgradually, but had a marked reduction in Ach contents in the cortex and hippocampus. After injection of PCPA and 5,7-DHT, a serotonergic toxin into the cerebroventricle in rats,we observed the colonic body tempera狀re and Ach contents of cerebral cortex. The results of our study are as follows : 1) Ach contents in the cortex were decreased significantly on the 3rd day & 7th day afterPCPA i.c.v. injection. 2) Ach contents in the cortex were not changed on the 3rd day & 7th day after 5,7-DHTi.c.v. injection. 3) Increase in colonic body temperature was markedly observed in rats on 3rd day & 7thday after received intracerebral PCPA injection. During handling with rectal probe insertionthere is a small changes of colonic body temperature with time. 4) Increase in colonic body temperature was observed in rats on 3rd day after receivedintracerebral 5,7-DHT injection. During handling with rectal probe insertion there is a smallchanges of colonic body temperature with time. So, we concluded that serotonin depletion could cause a decrease in Ach contents of thecortex and also increase in colonic body temperature via cholinergic system iii the brain.