간장 재생기간중 phenobarbital이 흰쥐의 담취 외분비 기능에 미치는 영향

裵瑛淑,金源准,洪思奭 최신의학사 1974 最新醫學 Vol.17 No.12

Most drugs undergo metabolic transformation in the body. The main site of drug metabolism is the liver. The microsomal enzymes of liver cell may be stimulated by administration of a number of drugs, particularly phenobarbital which increases markedly the activity of the liver enzymes. Lee et al. claimed that daily administration of phenobarbital in rats significantly increased the activities of amylase and lipase in the pancreatobiliary juice, but the concentration of cholate in the bile was significantly lower in the treated group than that in the control group. In this experiment, the effect of phenobarbital on exocrine secretion of pancreas and liver was obtained in rats having partial hepatectomy. The results obtained are summarized as follows: 1. After partial hepatectomy in rats, final liver weight was proportionally increased in progress of the experimental period and phenobarbital treated group was more increased than control group. 2. In the early period after partial hepatectomy, volume and bilirubin concentration in pancreatobiliary juice were increased but cholate level was markedly decreased following phenobarbital treatment. 3. Lipase and amylase activities in the juice were slightly increased throughout the period but no difference was detectable between two groups. By the above results, it is felt that the effect of phenobarbital on exocrine function of liver and pancreas in rats following partial hepatectomy was not marked.

茵蔯蒿의 膽汁分泌 機轉에 관하여

裵玲淑,洪永淑 梨花女子大學校 韓國生活科學硏究院 1980 韓國生活科學硏究院 論叢 Vol.25 No.-

漢方 및 민간에서 흔히 黃疸 치료에 사용하는 菌蔯蒿를 家兎에 투여하여 다음과 같은 결론을 얻었다. 1) 담즙 분비량은 菌蔯蒿 투여군에서 대조군에 비해 별다른 변화가 없었다. 2) 담즙 biliverdin은 菌蔯蒿 투여군에서 상당히 증가된 치를 나타내었다. 3) 담즙 cholate 치는 菌蔯蒿 투여군이나 대조군이 비슷하였다. 4) 담즙 cholesterol 치는 菌蔯蒿 투여군이 대조군에 비해 별 변화가 없었다. 5) 간장 microsome 內 cytochrome p-450은 菌蔯蒿 투여군에서 상당히 높은 치를 나타냄을 볼 수 있었다. Artemisia was used as folk medicine for hyperbilirubinemia. Kiku Tanni(1968) claimed that administration of Artemisia in patient with acute hepatitis, significantly lowered the bilirubin index, S.G.O.T and S.G.P.T. And Yokawa(1929) reported that I.V injection of Artemisia in rabbits revealed the increased volume of biliary juice. Therefore, ws decided to determine the mechamism of biliary excretion atter I.V. injection of Artemisia in rabbit. The results of this experiment were as follows:, 1. After I.V injection of Artemisia in rabbits, biliary juice volume was not increased than that of control group. 2. Biliverdin concentration in bile juice of rabbits treated with Artemisia significantly increased than that of control group. 3. Cholate and cholesterol concentration in bile juice of rabbit treated with artemisia was not increased than those of control group. 4. Liver microsomal cytochrome P-450 was increased significantly following Artenisia treat-ment.

흰쥐의 신선조체 파괴에 따른 흑질의 형태학적 변화 및 행동양상

배영숙 梨花女子大學校 醫科大學 醫科學硏究所 1988 EMJ (Ewha medical journal) Vol.11 No.4

After unilateral lesion of the rat neostriatum, we have been studied the relation between the behavioral chages of the rat and structural chages of the substantia nigra. We could find that a great number of axon terminals with pleomorphic vesicles in the ipsilateral substantia nigra were degenerated after one site lesion of neostriatum. while the structure of contralateral site was entirely intact. Also, we have been investigated that the contralateral asymmetry of posture and turning bebavior of the rat with lesion in the neostriatum. By the above results, it can be concluded that the axon terminal with pleomorphic vesicles in the substantia nigra ending of strio-nigral fibers and the degeneration of these ending is a cause to bring the contralateral postural asymmetry and/or circle behavior.

흰쥐 측뇌실 내 PCPA 투여가 5-HT와 Ach량의 변동에 미치는 영향

배영숙 梨花女子大學校 醫科大學 醫科學硏究所 1993 EMJ (Ewha medical journal) Vol.16 No.4

PCPA is a drug which depletes serotonin by inhibiting tryptophan hydroxylase activity.Recent evidence indicates that the ascending cholinergic projection from the basal forebrainand ascending serotonergic projections from the brain stem exert a powerful control over thegeneralized electrical activity of the hippocampus formation and neocortex. Cross & Dentin(1985) reported that destruction of ascending cholinergic neurons by injection of ibotenic acidinto the basal forebrain results in a significant reduction in 5-HT_1 receptor in the denervatedcortex. Maura & Raiteri(1986) observed that the release of (^3H) Ach was concentration depenendently inhibited by exogenous 5-HT in rat hippocampus. So, we were interested in investigating whether PCPA which depletes the serotonin alsoaffects the cholinergic system. The brain(cortex area 3, 4, 17 and hippocampus) were exisedon the 3day and the 7day after single injection of PCPA 3mg/10μl into the cerebroventricle(Lateral ventricle AP+8.2mm ; L, 1.5mm ; DV+1.2mm). 5-HT ant 5-HIAA contents were measured by HPLC-ECD and acetylcholine was measuredby GC. The results are 1) 5-HT & 5-HIAA contents in the cortex & hippocampus were decreased gradually afterPCPA injection but not significant. 2) Ach contents in the cortex & hippocampus were decreased significantly on the 3rd day& 7th day after PCPA injection. 3) We observed that the cerebral cortex has small amount of vesicles or no vesicles andcoated vesicles in the axon terminals by electron microscope. So, these results suggest that PCPA treatment results in significant changes of cholinergicsystem in the brain.

사염화탄소, phenobarbital 및 인진호 투여가 담관계에 미치는 영향

裵玲淑 梨花女子大學校 醫科大學 醫科學硏究所 1983 EMJ (Ewha medical journal) Vol.6 No.1

After animals were treatd with CCl_4, histological changes were shown in the endoplasmic reticulum, and also microsomal activity was decreased and hepatic necrosis, lipid peroxidation in the liver were repoted. Repeated administration of phenobarbital results in the induction of enzyme that metabolize a number of drugs and, Roberts and Plaa reported that bilirubin output was increased significantly after administration of phenobarbital in rats. Artemisia. was used as folk medicine for the treatment of hyperbilirubinemia. Kiku Tanni(1968) claimed that administration of Artemisia. in patient with acu-te hepatitis, significantly lowered the bilirubin index, S.G.O.T. and S.G.P.T. The purpose of the this report was to study the effect of CCl_4, phenobarbital. Artemisia on biliary excretion. The results obtained are summarized as follows. 1) Volume of the bile juice was decreased in CCl_4 group but increased in ph-enobarbital and Artemisia. group. 2) Biliary output was slightly decreased in CCl_4 group but increased in pheno-barbital group. 3) Cholate output was decreased in CCl_4 group, but phenobarbital and Artemi-sia group was shown sighificant increase. 4) Cholesterol output was decreased in CCL_4 group, but increased in phenobar-bital group. By the above results, it is felt that after treated with phenobarbital and artemisis following liver damage with CCl_4, detoxication process was shown and the liver damage were protected.

CHARLES BAUDELAIRE

배영숙 이화여자대학교 외국어교육과 1974 Foreign language teaching Vol.- No.7

측뇌실내 PCPA와 5,7-DHT 투여가 흰쥐 체온에 미치는 영향

배영숙,박혜영 이화여자대학교 생명과학연구소 1993 생명과학연구논문집 Vol.4 No.-

Simonic(1988) have investigated that hypothermic effect of cholinomimetics is mediated through an activation of muscarine cholinergic receptors. And also, Yamada(1987) injected tryptamine into the lateral cerebroventricle in mice and observed hypothermic through 5-HT_1 receptor. We have previously reported that PCPA(a serotonin depletor), has reduced 5-HT contents gradually, but had a marked reduction in Ach contents in the cortex and hippocampus. After injection of PCPA and 5.7-DHt, a serotonergic toxin into the cerebroventricle in rats, we observed the colonic body temperature and Ach contents of cerebral cortex. The results of our study are as follows: 1) Ach contents in the cortex were decreased significantly on the 3rd day & 7th day after PCPA i.c.v. injection. 2) Ach contents in the cortex were not changed on the 3rd day & 7th day after 5.7-DHT i.c.v. injection. 3) Increase in colonic body temperature was markedly observed in rats on 3rd day & 7th day after received intracerebral PCPA injection. During handling with rectal probe insertion there is a small changes of colonic body temperature with time. 4) Increase in colonic body temperature was observed in rats on 3rd day after received intracerebral 5.7-DHT injection. During handling with rectal probe insertion there is a small changes of colonic body temperature with time. So, we concluded that serotonin depletion could cause a decrease in Ach contents of the cortex and also increase in colonic body temperature via cholinergic system in the brain.

흰쥐에서 Handling과 주사에 의한 Stress로 야기된 고체온에 관하여

배영숙 梨花女子大學校 醫科大學 醫科學硏究所 1984 EMJ (Ewha medical journal) Vol.7 No.4

Experimental handling and colonic temperature measurement have been shown to cause stress and induce a long lasting rise in colonic temperature in the rat. Injection is also a type of stress to induce hyperthermia in the rats. In the pr-esent study, no difference was found between injection group and simple handling group.

흰쥐 측뇌실 내 PCPA 투여가 5-HT와 Ach량의 변동에 미치는 영향

배영숙 이화여자대학교 생명과학연구소 1993 생명과학연구논문집 Vol.4 No.-

PCPA is a drug which depletes serotonin by inhibiting tryptophan hydroxylase activity. Recent evidence indicates that the ascending cholinergic projection from the basal forebrain and ascending serotonergic projections from the brain stem exert a powerful control over the generalized electrical activity of the hippocampus formation and neocortex. Cross & Deakin(1985) reported that destruction of ascending cholinergic neurons by injection of ibotenic acid into the basal forebrain results in a significant reduction in 5-HT_1 receptor in the denervated cortex. Maura & Raiteri(1986) observed that the release of (^3H) Ach was concentration depenendently inhibited by exogenous 5-HT in rat hippocampus. So, we were interested in investigating whether PCPA which depletes the serotonin also affects the cholinergic system. The brain(cortex area 3, 4, 17 and hippocampus) were exised on the 3day and the 7day after single injection of PCPA 3mg/10㎕ into the cerebroventricle(Lateral ventricle AP+ 8.2mm: L. 1.5mm; DV+ 1.2mm). 5-Ht and 5-HIAA contents were measured by HPLC-ECD and acetylcholine was measured by GC. The results are 1) 5-HT & 5-HIAA contents in the cortex & hippocampus were decreased gradually after PCPA injection but not significant. 2) Ach contents in the cortex & hippocampus were decreased significantly on the 3rd day &7th day after PCPA injection. 3) We observed that the cerebral cortex has small amount of vesicles or no vesicles and coated vesicles in the axon terminals by electren microscope. So, these results suggest that PCPA treatment results in significant changes of cholinergic system in the brain.

개심술을 받은 환자에서 적용된 간호진단 분석

배영숙 성인간호학회 1994 성인간호학회지 Vol.6 No.1

This research was done for the improvement of practical appliance of Ng diagnosis and for the elevation of nursing quality(level). Ng students of the fourth grade of K university which is in Taegu cared for patients who were admitted for open heart surgery in the ICU. They practiced form march 5, 1992 to July 2, 1993, each for 3 weeks. After their practice, they reported on 31 cases which had a total of 204 Ng diagnoses. I analized the Ng diagnoses with 170 diagnoses used by NANDA and 34 diagnosis by non-NANDA through comparison diagnoses from NANDA. The general characteristics of the patients are as follow : by sex, men were 6 cases (19.4%) and women were 25 cases (80.6%). In age, 16∼39 were 9 cases (29.0%), 40∼49 were 11 cases (35.5%), and over 50 were 11 cases (35.5%). In diagnosis of the patients, AR & MR were 7 cases (22.6%), ASD were 2 cases (6.5%), MR were cases (54.8%), PS was 1 case (3.26%), Angina Pectoris (CABG) were 4 cases (12.9%). Ng students used all 204 Ng diagnoses. They used 170 NANDA in them, which means that one person used about 5.5 of NANDA's diagnoses. The diagnoses other than NANDA were 34(16.7%), which means one person used about 1.1 of non- NANDA's diagnoses. We think from this that non- NANDA's students do not have enough knowledge and experience in using diagnoses, and they tend to use their own diagnoses. All used NANDA's was 25 diagnoses in which the most popular diagnoses were ineffective air way clearance (48.4%), mobility, physical impairment, ineffective bleeding patterns, knowledge deficit, all of them were 41.9% in 31 cases. Kang showed self care deficit (27.7%), skin integrity (23.4%), tissue perfusion, alteration cerebral area (16.4%), and high risk for infection (0.6%), in her diagnosis analysis research of brain disease patients. Park(1987) showed the representative diagnosis of high risk for injury, altered nutrition less than body requirements, knowledge deficit, sleep pattern disturbance, knowledge deficit, sleep pattern disturbance, and fluid volume excess, in her evaluations, of the original and revelational research rate of five diagnosis in patients with CAAH or CAVH. When we consider the specifics of each patient we can determine how the Ng assessment reveals that patients problems differ according to their disease. Signs and symptoms are one thing, and nursing requests are another. The nursing diagnosis of 170 NANDAs according to age has 7.2 diagnoses per person in 40 through 49 years old. 5.5 diagnoses in those over 50. It is much more than 3.3 diagnoses in 16 through 39. The number of nursing diagnoses as medical diagnoses didn't have difference, in those 5.0 through 7.0. Nursing diagnoses as of the day of admission in the ICU was 6.6 diagnoses of NANDA person for 3 through 5 days. 31 patients were in the ICU after having open heart surgery, and it seems that nursing problems and requirements of patients were not different. The specific response-formal analysis in exchanging (52.0%), moving (12.0%), feeling (12.0%), knowing (8.0%) in 25 diagnoses, is similar with the research of Park, Lee (1989) who showed exchanging (43.7%), feeling (23.5%), moving (19.3%), perceiving (4.0%), knowing (3.8%). The related factors of ineffective air was clearance were painkillers or sedatives (53.3%), and secretion(40.0%). Using painkillers and sedatives I think must result in energy decrease or fatigue. The related factors of impaired physical mobility were due to pain and discomfort in NANDA. And attachment of instrument (30.8%) cannot be used as the related factor. The related factors of ineffective breathing pattern, heart failure (23.1%) can't be used as medical diagnoses, so it must be changed to energy decrease or fatigue. As the related factor of knowledge deficit, there was a perceiving deficit (53.8%) which is represented as a knowledge deficit in NANDA and which I think is more familiar using the word confusion. The relation of anxiety was in connection with the change of health situation (81.8%), and economical problem (9.1%). Another related factor is operation (9.1%) which doesn't belong to NANDA. Operation itself is the change of health situation which must be the related factor.