주정 중독에 있어서의 ALDH Isoenzyme 형태에 관한 연구

백기청,서성원 국립서울정신병원 1988 臨床硏究論文集 Vol.1988 No.-

스트레스와 생활사건 : 방법론 및 정신질환과의 관련성을 중심으로 Its Relation on Psychiatric Illness

백기청 漢陽大學校 精神健康硏究 1991 精神健康硏究 Vol.10 No.-

스트레스와 정신분열병의 관계에 관한 연구

백기청,박영원 국립서울정신병원 1993 臨床硏究論文集 Vol.1993 No.-

한국인 알콜중독환자에서 Aldehyde Dehydrogenase Ⅰ 유전자 변이에 대한 연구

백기청 국립서울정신병원 1993 臨床硏究論文集 Vol.1993 No.-

韓國成人男子 알코올중독환자의 Aldehyde Dehydrogenase-I 遺傳子 變異에 따른 性格特性의 差異 比較

백기청 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.1

Objects : Since it has been supposed that unpleasant flushing reaction in Orientals after alcohol ingestion is probably arised from the deficiency of ALDH-I(aldehyde dehydrogenase-Ⅰ), the enzyme working on the 2nd step of alcohol metabolism, the deficiency of this enzyme are inclined to be aversive to alcohol beverage and have few chance of being alcoholics, But in the previous study done by the author and his colleagues. a few alcoholics in Korea are proven to have atypical ALDH-Ⅰ genotypes ie, to be deficient of this enzyme. And in many of them. life event stressor played a role as precipitator of being alcoholics. Also they were more of late onset type and had more tissue damages induced by alcohol and physical dependence and deteriorating course than those who had normal ALDO-I genotype. In this study, by comparing personality trait among different ALDO-Ⅰ genotype, the author wants to elucidate the necessity of the different approach especially in psychological aspect in the prevention and treatment of alcoholism in terms of ALDO-Ⅰ genotype. Methods : We analysed the ALDO-Ⅰ genotype with 102 admitted Korean adult male primary alcoholics by DAM Ⅲ-R criteria and compared the personality trait between different ALDH-Ⅰ genotypes, For the evaluation of the personality trait, five established scales were used : EPQ, Locus of Control, 16PF, TPQ and Spielberger's Trait Anxiety Scale. Results : In ALDH-Ⅰ genotype assay among 102 alcoholic subjects, 85 one(83.3%) had the usual NN type, 17 one (16.67%) had atypical ND type and no one(0.00%) had DD type, so we compared the personality trait between NN and ND type. As a result, those who have ND type compared to NN type were proven to had more introverted, dependent and serious character trait. Conclusion : Those who had atypical ND type ALDH-Ⅰ gene had introverted, dependent, serious personal character and lack of self confidence. So instead of confronting external stressor, they passively use alcohol as a more easily defense arms. We could say that it's similar to the Schuckit's ‘milieu limited’ ‘type 1’ ; in a sense that onset is late, it's external stress related, has more passive and evasive character triat, high psychological dependence. In this context, dealing with those who have atypical ALDH-Ⅰ genotype, we should consider this psychological aspect in the prevention and treatment of alcoholism.

서울지역 가정주부의 초기상실 경험과 생활 사건이 우울에 미치는 영향

사승언,양병환,백기청 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.2

For the purpose of unraveling whether early loss influences the later depression, 500 housewives in the Seoul area were sampled by the multi-stage probabilistic stratified sampling. The Beck Depression Inventory (BDI) and the Life Event Stress Rating Scale of Housewives (LERS) constructed by Yoo et al. (1994) were administered to all the subjects. Early loss was defined as the loss before 15 years of the subjects age. The early loss, as a whole or as in sperate age groups, proved to have no influence on the BDI score. In the younger groups under the 50 years of age, the early loss according to each area of recent life event stress did not affect BDI score. But, only in the elderly group over the age 50, the experience of recent life event stress was proved to have influence on the BDI score in the early loss group. The early loss group, compared to the loss-free group, was lower in the BDI score when they had no experience of stress factors "the economy and job" and "the change of life circumstance", but equivalent when they had experience of the above stresses. The early loss group was lower in the BDI score when they had no experience of stress factor "separation", but higher in the BDI score when they had experience of stress of recent separation. The above findings suggest that the early loss group, with no experience of recent stress, is less depressed in the elderly life than the loss-free group and the recent life event such as "the separation" possibly provokes depression in the early loss group.

만성 정신분열병 환자에서 다음증과 물중독 위험군의 임상적 특성-표준화 일중체중증가를 이용하여

김차식,김혜남,백기청 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

연구배경 : 만성 정신분열병 환자들에서 다음증과 물중독은 임상가의 인식부족 등의 이유로 흔히 간과되어 왔으며, 이들의 임상적 특성에 대해서는 논란이 되고 있다. 본 연구는 다음증과 물중독의 위험군을 검색하는 방법으로 경제적이고 간편하다고 알려진 표준화 일증체중증가를 이용하여 비정상적인 일중체중증가를 보이는 만성 정신분열병 환자들의 임상적 특성을 알아 보고자 하였다. 방법 : 1995년 7월에서 1995년 10월 사이에 국립서울정신병원에 입원한 2년 이상된 정신분열증 환자 156명을 대상으로 3주간 매주 1회씩 7 a. m.과 4 p.m.에 각각 체중을 측정하여 표준화 일중체중증가를 구하였다.표준화 일중체중증가는 오전 체중에 대한 오후 체중의 증가비율로서 4 a.m. 체중에서 7 p.m.체중을 뺀 후 100을 곱하였고 그 값을 7 p.m. 체중으로 나눈 값(%)인데, 비정상적 표준화 일중체중증가는 1.2% 이상을 기준으로 하였다. 이와 함께 향정신병 약물, 정신분열병의 예후예측변인 및 체형을 조사하여 비교하였다. 결과 : 대상 환자가운데 비정상적인 일중체중증가를 보이는 환자들은 35.9%를 차지하였고, 이들은 남자, 저역가 약물복용, 흡연, 장기간의 입원경력 및 상대적으로 마른 체형 등의 임상적 특성을 보였다. 결론 : 이상의 임상적 특성을 보이는 만성 정신분열병 환자들은 다음증과 물중독의 위험군이라 볼 수 있으며, 따라서 실제 임상에서 이러한 특성을 보이는 만성 정신분열병 환자들은 다음증 및 물중독의 위험에 관한 임상가의 인식이 필요하다. Objects : Polydipsia and water intoxication among chronic schizophrenic patients is poorly understood and underdiagnosed due to lack of awareness among clinicians, and their clinical characteristics are controversial issues at present. We attempted to identify clinical characteristics of chronic schizphrenic inpatients who had abnormal normalized diurnal weight gain, an economic and easy method for screening the risk group of polydipsia and water intoxication. We also assessed the factors that may contribute to abnormal normalized diurnal weight gain. Methods : One hundred fifty-six chronic schizophrenic inpatients(From July, 1995 to October,1995) at Seoul National Mental Hospital were studied. They were weighed at 7 a.m. and 4 p.m. weekly for 3 weeks. We normalized the diurnal weight gain as a percentage by substracting the 7 a.m. weight from the 4 p.m. weight, multiplying the difference by 100, and dividing the result by the 7 a.m. weight. We defined the abnormal normalized diurnal weight gain as above1.2%, according to the previous study of Davidson et al(1976). We estimated current psycho-tropic medication, prognostic factors of schizophrenia and body type, and compared those with normalized diurnal weight gain values. Results : About thirty-six percent of the subjects had abnormal normalized diurnal weight gain values. The chronic schizophrenic inpatients with abnormal normalized diurnal weight gain were clinically characterized by being male, using low potency antipsychotics, smoking, extended hospitalization and relatively low body mass index score. Conclusions : We suggest that the risk of polydipsia and water intoxication in chronic schigophrenic inpatients are increased, by being male, using low potency antipsychotics, smoking and having extended hospitalizations and relatively low body mass index score. Therefore in psychiatric practice, clinician's awareness about these correlations are warranted.

일반인과 정신과 환자 보호자들의 정신질환에 대한 인식과 태도에 관한 연구

박정우,곽영숙,백기청 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

This study was conducted to examine the knowledge and attitude toward mental illness in the lay people and the psychiatric patients' caretakers from December 1993 to October 1994. 242 lay people who were the parents of the students in an elementary school and 164 psychiatric patients' caretakers at Seoul National Mental Hospital were asked to answer a questionnaire about mental illness. In addition, parent Bonding Instrument(PBI) was used to determine the parental bonding style in 94 psychiatric patients' caretakers. And the results were as follows : 1) the primitive, supernatural concepts toward mental illness were significantly high in caretakers and in low educational group. 2) The psychological, environmental concepts toward mental illness were significantly high in female and in low educational group. 3) The negative attitudes toward the mentally ill were significantly high in female caretakers and in older age group and how educational group. 4) The caretakers' negative attitude toward the mentally ill were significantly associated with increased number of admissions. 5) The Mothers had more psychological, environmental concepts and more negative attitudes toward mental illness than the siblings in caretakers. 6) The negative attitudes toward the mentally ill were significantly associated with high level of parental overprotection and low level of parental care and the primitive, supernatural concepts toward mental illness were significantly associated with high level of paternal overprotection and low level of paternal care. We suggest that educational programs on the mental illness, especially for the primary caretakers, are necessary for early detection and treatment of illnesses, prevention of relapses- and rehabilitation.

회화요법에 있어서의 전이문제

백기청 韓國臨床藝術學會 1990 임상예술 Vol.6 No.-

韓國成人 男子 알코올 中毒 患者에서 Aldegyde Dehydrogenase-I遺傳子 變異에 따른 飮酒樣態의 差異 比較

白基淸,李定均,金容植,李澤重,白龍均 서울大學校 醫科大學 精神科學敎室 1992 精神 醫學 Vol.17 No.3