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      • 접착제(본드)흡입이 간장의 기능 및 조직변화에 미치는 영향

        김인수,손동렬,신인철 漢陽大學校 環境科學硏究所 1984 環境科學論文集 Vol.5 No.-

        접착제의 흡입으로 일어날 수 있는 유해작용에 대하여는 이미 많은 연구가 이루어져 왔으나 그 유해작용은 접착제 제조에 사용된 유기용매의 종류와 순수성에 따라 좌우되므로 만성독성으로 인한 신경장애에 대한 작용이외에 많은 연구들이 일치된 견해가 없고 각 나라마다 자국산의 접착제에 대하여 철저한 연구가 이루어져 왔으나 우리나라에선 거의 연구되어 있지 않는 실정이다. 따라서, 우리나라에서 생산되는 접착제의 흡입으로 일어날 수 있는 만성독성에 대한 연구가 필요하여 백서에 장기간 접착제를 흡입시켰을 때 특히 간 기능과 조직변화에 미치는 영향을 연구하였다. 접착제는 사용된 유기용매의 종류에 따라 toluene과 acetone이 주 용매인 Gt와 hexane과 acetone이 주 용매인 Gh 2 종류로 구분하였으며 실험동물은 체중 180g 내외의 웅성 백서를 대조군, Gt 흡입군과 Gh 흡입군 3군으로 나누었다. 1) 접착제를 10분간 흡입시키는 동안에는 약간의 흥분작용 이외에 별다른 증상을 볼 수 없었으나 40일간의 흡입에서 부터 흥분작용이 증가되어 공격적이며 적의심을 나타냈다. 이러한 중추신경에 대한 영향은 Gt 흡입군에서 더욱 심화하였고 흡입이 중단된지 60일이 경과되어도 정상으로 회복되지 않았다. 2) 혈청 GOT와 GPT는 10일에서 부터 증가되어 30∼40일에 최고의 증가치를 나타냈으나 흡입이 계속되고 있음에도 감소되였다. 혈청 alkaline phosphatase 수준은 20일에서부터 증가하여 50 일까지 지속되었으나(59.2%∼73.1%) 60일에서는 감소되었다. 총 bilirubin은 전 실험기간에서 별 변동이 없었으며 혈청효소의 변동은 흡입이 중단된 후 20일에서는 거의 정상수준으로 회복되었고 Gt와 Gh 흡입군에서 유의한 차이가 없었다. 3) 간의 무게를 체중비로 나타낸 결과 20일에서 부터 25% 증가되었고 60일에서는 50%의 증가를 나타냈으나, 흡입이 중단된 후 50일이 경과되어서는 정상으로 회복되는듯 하였다.(Gt 12.2%, Gh 16.3%) 4) 간의 병리 조직학적 소견으로는 20일에서 문맥주변부의 염증 세포 침윤, 충혈 및 간세포 종창이 관찰되었으나, 흡입이 계속되고 있음에도 더 이상 약화되지 않고 60일간 같은 변화를 보였다. 흡입이 중단된 후 40 일에서는 정상 조직상태를 나타냈으며 이러한 조직변화는 Gt와 Gh 흡입군에서 별 차이가 없었다. 이상의 결과로 보아 우리나라에서 생산되는 접착제의 만성흡입은 내성의 출현으로 인하여 특정적인 심한 간 손상을 유발하지 않는 것으로 판단되며 간 기능 손상은 조직변화에 선행되어 나타나고 간 기능 및 조직손상은 회복성이 있는 것으로 사료된다. 우리나라에서 생산되는 접착제는 비교적 장기간 백서에 흡입하여 다음과 같은 결론을 얻었다. 접착제의 만성흡입은 특징적인 심한 간 손상을 유발하지 않았으며 이는 내성의 출현으로 인한 것으로 판단되고 간 기능 손상은 조직 변화에 선행되어 나타나고 간 기능 및 조직 손상은 회복성이 있는 것으로 사료된다. There have been a number of studies on the acute and chronic toxicities induced by continuing, heavy exposure to glue or its solvents. However the reports besides on the neuronal damage are still controversial, for the toxic actions probably depend on the kind and purity of the solvents used in glue. The aim of the present study was to evaluate the effect of chronic exposure to the inhalation of glue on the functional and histological liver damages. 210 healthy Sprague-Dawely male rats weighing about 180g. were divided into 3 groups: 1)control group exposed to the inhalation of fresh air, 2) Gt group exposed to the inhalation of glue whose main solvents were toluene and acetone, 3) Gh group exposed to the inhalation of glue whose main solvents were hexane and acetone. The results obtained were as follows: 1) During 10 minutes exposure to the inhalation of glue, slight excitement was observed in all rats and in 40 days exposure, excitement was more profound and aggressiveness and hostility were found in Gt group rather than Gh group. The excitement was not subsided even 60 days after stopping inhalation. 2) Serum GOT and GPT levels were elevated in 10 days exposure and reached to the highest level in 30∼40 days exposure followed by decrease to normal ranges. Serum alkaline phosphatase level remained raised from 20 days to 50 days exposure (59.2%∼73.1%) and returned to almost normal level in 60 days exposure. Total bilirubin level were within normal limits in all experimental period. The serum enzyme levels were recovered to normal ranges 20 days after being exposed to the final inhalation and have no significant difference between Gt and group. 3) The relative liver weights were increased by 25% in 20 days exposure, and by 50% in 60 days exposure but it seemed to be returned to normal weight 50 days after stopping inhalation (Gt 12.2%, Gh 16.3%). 4) The histopathological changes induced by 20 days exposure to the inhalation of glues Gt and Gh were mononuclear cell infiltration in periportal zone, congestion and cellular swelling on the liver and were not enhanced even by increase in exposure time. These findings were completely subsided 40 days after receiving the final exposure. From these results, it may be concluded that the chronic inhalation of glues available in Korea fails to cause severe or characteristic liver disease, the functional damage is followed by the histological changes in liver and the functional and histological damages are reversible.

      • Robert Lowell의 Life Studies의 유기적 통일성

        신인철 동아대학교 인문과학대학 인문과학연구소 1994 인문과학연구 Vol.- No.-

        This paper aims at finding an organic unity in Robert Lowell's Life Studies. It is rare that a book of poems by a poet has an organic unity in it. However, going through Life Studies, I have come to conclude that there is an organic unity in it. The theme of "The Fall of the House of Lowell and the Poet's Breakthrough" permeates the whole book. The book is composed of four parts. ''Beyond the Alps," the first poem announces that Lowell has left Roman Catholicism and chosen to go to Paris to encounter lie's trials, that he may order chaos in his lie and world into poetry. The second deals with the historical figure, Marie de Medici, who is presented as a persona for his mother. The third, which, on the occasion of Eisenhauer's Inaugulation, contemplates the corrupt Administration of President Grant. The poem prepares for the appearance of Lowell's father who resigned the Navy. The fourth poem of Part I depicts ''a mad negro soldier confined at Munich," which foreshadows Lowell's life-long struggle with manic-depressive illness. So Part I is a historical prelude to the disintegration of Lowell's family and the world. Part Ⅱ is Lowell's reminiscence in prose of his childhood, wherein he probes the source of his madness. It is depicted through the eyes of young Lowell. Part Ⅲ is the portraits of four artists who have exiled themselves. Lowell might have shared their destinies because of his affinities with them. The fourth poem about Hart Crane, which is really "an epitaph for a fallen post", raises the question of madness and suicide. Part Ⅲ is Lowell's parabolic autobiography. Though the present paper does not deal with Part Ⅳ, mention must be made of it. Part Ⅳ is entitled "Life Studies Ⅰ, 11", which is the family portraits, beginning, with the death of Uncle De´vereux. The poems are arranged in the order of family members' deaths. "Life Studies I" deals chiefly with outward events, whereas "Life Studies Ⅱ" is related to to Lowell's inward world which is troubled with incarceration as a conscientions objector and mental case. The fourth poem, 'Skunk Hour', raising the question of madness and suicide, depicts the poet overcoming "the approach of a crisis of mental disorder" and suicide and born again as a true artist, invigorated at the sight of skunks scavenging filth, the refuse of civilization. Thus there runs through Life Studies the plot of "The Lowell Family Saga" which surmounts difficulties, achieving an organic unity (what was before reappearing afterward), which helps one read Life Studies as if he were reading a novel. In Life Studies Lowell has become a chronicler and historian of the Lowell family, writing his own version of history.

      • 실험동물 창상면에서의 수용성 지혈면 Satin-100의 지혈효과와 생체흡수성 및 조직재생효과에 대한 비교연구

        강주섭,이창호,신인철 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.2

        The absorbable stanching Satin-100 was made by a chemical denatured treatment of cotton fibrous styptic gauze and allowed it to be improved hemostatic efficacy and bioabsorbability. This study was undertaken to evaluate hemostatic efficacy of the Gelfoam, Beriplast-P, and Satin-100 when applied to bleeding surfaces after excision cortical region of the middle edge of the kidney and bioabsorbability of these agents after implantation of these agents in femoral muscular regions during 4 weeks in teh Sprague-Dawley rats. Satin-100 and Beriplast-P were showed the complete hemostatic efficacy and weak bleeding with no more agents, on the other hand, Gelfoam showed incomplete hemostatic efficacy and needed more agents or renal vessel ligation after 4 minutes in application of these agents in partially resected kidney. The hemostatic efficacy of Satin-100 and Beriplast-P significantly (p<0.05) showed better than Gelfoam. Over-all evaluation of the histopathological changes in the light microscopic fields of the femoral muscular regions of implantation of Satin-100 showed less inflammatory reaction, fewer phagocytes, better bioabsorbability and tissue regenerative effects than other agents. Therefore, we suggested that Satin-100 would become the good topical hemostatic material which has the following characteristics : high hemostatic action, In vivo biodegradability, minimal tissue reactivity.

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