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RISS 인기검색어
- 검색키워드
- 저자 : 玄悳燁 (검색결과 5 건)
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物質代謝에 미치는 Progesterone의 影響 및 Progesterone 前處置 家兎의 摘出循環器에 對한 Norepinephrine의 效果
玄德燁,申萬鍊 고려대학교 의과대학 1974 고려대 의대 잡지 Vol.11 No.2
In order to investigate the influence of progesterone on the metabolic effect, the author stuaied the changes of blood sugar, serum total cholesterol, serum Ca and Mg concentration, serum transaminase activities (GOT, GPT) and cardiac catecholamine contents of rabbits treated with progesterone for 2 or 10 days. In addition, the response of norepinephrine on the contraction of isolated auricle and aortic strip of rabbits pretreated with progesterone have been observed. The results were obtained as follows ; 1. The blood sugar concentration was increased by the treatment of progesterone. 2. The serum total cholesterol concentration was increased by the treatment of progesterone for 10 days. 3. The serum Ca concentration was decreased and serum Mg concentration was increased by the treatment of progesterone for 2 days. 4. The serum transaminase activities (GOT, GPT) were increased by the treatment of progesterone. 5. The cardiac catecholamine content was decreased by the treatment of progesterone. 6. The response of norepinephrine on the isolated auricle of rabbit was tended to increase by the pretreatment of progesterone but the isolated aortic strip was tended to decrease.
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Lithium Chloride의 循環器 및 腸管에 對한 作用
南在重,玄悳燁,洪權熹,金陽順 최신의학사 1973 最新醫學 Vol.16 No.11
Until 1949, lithium chloride was used as a substitute for sodium chloride in patients with congestive heart failure for whom sodium-free diet were prescribed. But it's clinical use was banned by the toxicity of the lithium ion. Since the mid-1950s, owing particularly to the efforts of Schou, lithium salts has been used extensively in the treatment of manic-depressive psychosis, and many studies have been made about it. In this paper the effect of lithium chloride on the blood pressure, contractile effect of the excised auricle and intestine, and catecholamine contents in heart muscle of the rabbits were investigated. The results obtained were summarized as follows: 1. Large dose (50mg/kg) of lithium chloride elevated blood pressure and inhibited norepinephrine response on the blood pressure. 2. Large dose (47.2mM) of lithium chloride increased contractile effect of the isolated auricle and inhibited epinephrine response on the isolated auricle. 3. Large dose (47. 2mM) of lithium chloride decreased contractility of the isolated intestine and inhibited epinephrine response on the isolated intestine. 4. Cardiac catecholamine contents were decreased by the treatment of lithium chloride(25mg/kg) for 5 days.
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알콜投與家兎의 血中알콜濃度, 血糖量 및 血淸 Transaminase 活性度에 미치는 人蔘水溶 액기스의 效果
李曾子,洪權憙,玄德燁,金陽順 中央醫學社 1973 中央醫學 Vol.25 No.6
In this paper, the influence of Panax ginseng on the alcohol metabolism and metabolic effects of alcohol were studied. Through the experiments, the alcohol concentration in blood, blood sugar levels and serum °ansaminase (GOT, GPT) activities in rabbits were measured. In experimental group, rabbits were pretreated with water extract of Panax ginseng 10 minutes, prior to alcohol administration. The results were obtained as follows; 1) The increased blood alcohol concentration after alcohol administration were inhibited by the pretreatment of ginseng extract. 2) The elevated blood sugar levels induced by alcohol administration were reduced by the pretreatment of ginseng extract. But the blood sugar levels which were not changed by alcohol administration for 2 weeks, were not influenced by the pretreatment of ginseng extract. 3) The increased S-GOT activities induced by alcohol administration were inhibited by the pretreatment of ginseng extract. But the S-GPT activities which were not changed by alcohol administration, were not influenced by the pretreatment of ginseng extract.
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Chlorpromazine 및 Reserpine의 血糖 및 血淸 Transaminase 活性度에 미치는 效果
申庚澈,朴貞仁,玄德燁,洪權熹 中央醫學社 1973 中央醫學 Vol.24 No.6
It is well known that both of chlorpromazine and reserpine liberate the catecholamine from various organs. But the liberating mechanism of catecholamine of each is different. So called, chlorpromazine inhibits the uptake of catecholamine and reserpine depletes the catecholamine from it's store site. The effect of chlorpromazine and reserpine on the metabolism is still not well known. So in this paper, the authors attempt to investigate the effect of those agents on the glucose metabolism and transaminase activities in rabbits. The results were obtained as follows 1. The blood sugar levels in rabbits treated with chlorpromazine and reserpine relatively tend to increase, but the increasing rate of blood sugar is marked in reserpine treated rabbits. 2. Both of chlorpromazine and reserpine have a tendency to increase the activities of serum transaminases in rabbits. The serum GOT activities in rabbits treated with reserpine prior to experiment 24 hours are markedly increased but the serum GPT activities are significantly increased in 1 hour after injection of both agents.
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