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杉山政則,白舜英,能美良作 한국산업미생물학회 1985 한국미생물·생명공학회지 Vol.13 No.1
Much of the progress in genetic engineering has been accomplished by employing Escherichia coli as the host organism. For many reasons, however, some other organisms have greater potential as alternatives to E. coli. In particular, streptomycetes are attractive organisms as hosts especially for the producation of various secondary metabolites such as antibiotics. In this article, therefore, we reviewed the techniques for development of vector system and expression of genes for antibiotic biosynthesis in streptomycete hosts.
항생물질생산균의 단백질합성계조해항생물질(蛋白質合成系阻害抗生物質)에 대한 자기내성기구와 생합성유전자
양한철,백순영,삼산정칙 한국농화학회 1988 Applied Biological Chemistry (Appl Biol Chem) Vol.31 No.4
Streptomycetes are attractive microorganisms for their production of various secondary metabolites such as antibiotics. Now, the development of gene manipulation in this microorganisms enables the cloning and analysis of the genes which coding for antibiotic biosynthesis and resistance to the drug. In this article, we reviewed the studies with respect to the mechanisms of self-protection and cloning of the genes cloning for antibiotic biosynthesis, particularly, in microorganisms which produce antibiotic inhibitors of protein synthesis.