정신분열증과 주요 우울장애에서 Natural Killer Cell 수와 백분율 변화NK cell

윤장봉,이재우,박두병 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.5

The purpose of this study was to compare the number and percentage of natural killer cell in schizophrenic and major depressive patients with those in normal healthy subjects 15 Schizophrenic patients, 15 major depressive patients and 16 healthy subjects were included in this study There was no statistical difference in the age and sex between patients and control subjects. All of these patients were drug-free for at lest two weeks before this study. The results of this study were as follows : 1) In schizophrenic patients, the number and percentage of natural killer cell of the group with below-mean score of general psychopathology were significantly lower than those of the group with above-mean score(p<.05). The number but not the percentage of natural killer cell of the group with below-mean BPRS score was significantly lower than that of the group with above-mean BPRS score(p<.05). 2) The number of natural killer cell showed statistically negative correlation with generalpsychopathology score or BPRS score(p<0.05). In conclusion, these findings suggest that the number and percentage of natural killer cell is not significantly changed in schizophrenia and major depressive disorder, but in schizophrenic patients, severe psychopathology in the rating scales is associated with suppression of the number and percentage of natural killer cell.

원형 탈모증과 안드로겐성 탈모증 여성의 정신적 특성에 관한 연구

박두병,진성남,민경준,노병인,Park, Doo-Byoung,Jin, Seong-Nam,Min, Kyung-Jun,Noh, Byung-In 한국정신신체의학회 2005 정신신체의학 Vol.13 No.1

연구목적 : 장기적인 탈모증의 심리적 영향에 대해 알아보기 위해 탈모증을 겪는 여성 환자에서의 불안, 우울, 감정 표현불능증, 성격 특성에 대해서 알아보았으며, 더불어 유전적 생물학적 원인이 크게 작용하는 안드로겐성 탈모증과 정신적 스트레스의 병인론적 역할에 대한 논란이 있는 원형 탈모증간에 심리적 특성에서 차이가 있는지 알아보았다. 방법: 여성 탈모증 환자를 대상으로 최소 1년 이상 치료를 받고 있는 원형탈모증 환자군(52명)과 안드로겐성 탈모증 환자군(33명), 그리고 정상대조군(54명)에서 다면적 인성검사(MMPI), 벡 우울척도(BDI), 상태불안척도(STAI-S), 특성불안척도(STAI-T), 토론토 감정표현불능증척도(TAS-20K)를 시행하여 각 군간의 차이를 비교 분석하였다. 결과: MMPI 결과는 F척도, Hs척도, D척도, Pd척도, Pa척도, Sc척도, Si척도에서 탈모증 환자군이 정상대조군보다 통계적으로 유의하게 높았고, Hy척도, Pt척도는 안드로겐성 탈모증 환자군에서 가장 높았다. BDI 점수, 상태불안척도, 특성불안척도에서 정상대조군에 비해 원형 탈모증과 안드로겐성 탈모증에서 점수가 높았으며, 특히 BDI 점수에서는 심한 우울증(23점 기준)에 해당하는 경우가 원형 탈모증 환자에서 94.2%(49명), 안드로겐 탈모증 환자의 97.0% (32명)로 나타났다. TAS-20K의 경우 총점에서는 환자군이 정상 대조군에 비해 유의하게 높았으며, Factor 3에서 안드로겐성 탈모증이 타 군에 비해 유의하게 높은 점수를 보였다. 또한 STAI-S 및 STAI-T에서도 환자군이 정상대조군에 비해 유의하게 높은 점수를 보였다. 결론: 여성 만성 탈모증 환자에서 우울감이 두드러지고 불안 수준이 높으며 감정표현불능증의 정도가 더 심한 것으로 나타났다. 특히 이러한 결과는 탈모의 병인론에 관련된 논란에도 불구하고, 두 종류의 탈모증에서 거의 모든 환자가 가지는 우울감에 대해서 적극적인 정신과적 개입이 필요하며, 환자의 성격적 측면과 심리적 대처기 전을 고려해야 함을 의미한다. Objectives : We have studied female patients with either alopecia areata or androgenetic alopecia to evaluate psychological aspects, such as anxiety, depression, alexithymia, and characteristic personalities. In addition, we tried to examine the differences in psychological characteristics between these two types of alopecia, where the alopecia areata has been cotroversial on the role of stress in its etiology and the androgenetic alopecia seems to be more influeced by genetic and biological factors. Methods : All participated patients were females with alopecia for more than 1 you. Among them, 52 were with alopecia areata and 33 were with androgenetic alopecia. They were compared with 54 normal healthy controls by using MMPI, BDI, STAI-S, STAI-T, and TAS-20K. Results The average scores of F, Hs, D, Pd, Pa, Sc, Si in MMPI of alopecia groups were significantly higher than that of normal controls, and the androgenetic alopecia group had highest Hy and Pt scores. The average scores of BDI, STAI-S, and STAI-T in alopecia groups were higher than the normal controls. 94.2% of alopecia areata patients and 97.0% of androgenetic alopecia patients had severe depression, who scored higher than 23 in BDI. In TAS-20K, the average total scores of alopecia groups were higher than the normal control group, and the average Factor 3 score in androgentic alopecia was higher than the other groups. The alopecia groups scored higher than normal control group in STAI-S and STAI-T. Conclusion : Females with chronic alopecia were more depressed, had higher levels of anxiety, and more alexithymic than normal healthy females. In spite of arguments about etiological role of stress to alopecia, psychiatric interventions are needed for depression, and considerations for personality and psychological defense mechanism were needed in both types of alopecia.

원형 탈모증 환자에서의 감정표현불능증

박두병,전창무,손인기,민경준,김영돈,노병인 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.5

연구목적 : 감정표현불능증이 정신신체질환의 특징적인 성격 경향 인지에 대해 논란이 많이 있어 왔다. 이에 정신신체질환이면서 피부과 외래 환자의 다수를 차지하는 원형탈모증 환자에 있어서의 감정표현불능증에 대해 알아보았다. 방 법 : 원형탈모증 환자군(31명)과 연령, 성별을 대비시킨 정상대조군(31명)에서 MMPI, SCL-90-R, TAS-20K를 시행하였다. 정신신체질환 이외의 질환에 의한 영향을 배제하기 위해 다른 정신과 질환이 있다고 판단되는 경우는 제외시켰다. 집단간의 비교를 위해 paired t-검증을 실시하였다. 결 과 : 원형탈모증 환자군에서 MMPI 결과는 F 척도, K 척도, Hs 척도, D 척도, Hy 척도, Pd 척도, Pa 척도, Pt 척도, Sc 척도의 점수가 정상대조군에 비해 의미있는 차이를 보였고(p<0.05), SCL-90-R 점수에서는 SOM 척도, O-C 척도, I-S 척도, DEP 척도, ANX 척도, HOS 척도, PHOB 척도, PAR 척도, PSY 척도, GSI, PSDI, PST 점수가 정상대조군보다 유의하게 높은 점수를 보였다(p<0.05). 또한 TAS-20K 점수에서는 환자군이 정상대조군에 비해 Factor 1과 총점에서 유의하게 높은 점수를 보였다(p<0.05). 결 론 : 결론적으로, 원형 탈모증 환자군에서 정상 대조군에 비해 감정표현불능증이 더 심하고 특히 자신의 느낌을 잘 알지 못하는 것으로 나타났다 이는 원형탈모증 환자의 심리적인 대처기전을 세워 나가는데 좀더 주의를 기울이고, 더 많은 관심을 가져야 한다는 것을 의미한다. Objectives : Alexithymia has been regarded as the general personality of psychosomatic disease, but it's controversial. The object of the study is to find out the relationship between alexithymia and alopecia areata. Methods : Thirty one alopecia areata patients were compared to 31 normal healthy persons in alexithymic tendency using TAS-20K Also MMPI and SCL-90-R were checked in both groups. Psychiatric diseases were ruled out. Results : The scores of F, K, Hs, D, Hy, Pd, Pa, Pt and Sc of MMPI in alopecia areata patients were different from those in normal healthy persons. The scores of SOM, O-C, I-S, DEP, ANX, HOT, PHOB, PAR, PSY,GSI, PSDI, and PST of SCL-90-R in alopecia areata patients were significantly higher than those in normal healthy persons. In TAS-20K, the scores of Factor I and Total in alopecia areata patients were higher than those in normal healthy persons. Conclusion : Our results suggest that alopecia areata patients are more alexithymic than normal healthy persons.

쵸서의 英語에 나타난 强變化 四類動詞의 硏究

朴兜秉 순천대학교 어학연구소 1998 어학연구 Vol.9 No.-

The purpose of this article is to prove two hypotheses. The first is that the strong verbs of class Ⅳ in Chaucer's English did not change to week verbs as in the other works of the same period and the second is that the forms of the same strong verbs are different in the same tenses, because Chaucer's English was transitional language and the spelling wasn't fixed. The results of investigation obtained through my reseach and analysis of the 17 strong verbs of class Ⅳ in The comlete works of Geoffrey Chaucer edited by F. N. Robinson are as follow. 1. In Chaucer's English there were 17 strong verbs of the class Ⅳ which 15 verbs(88%) had only strong forms and 2 verbs(12%) had only week forms. 2. This class kept more verbs that had only strong forms than the other classes of strong verbs in Chaucer's English. 3. The verbs of this class hsd never strong forms besides weak forms enen though the verbs of the other classes in Chaucer's Enghish hsd strong forms besides weak forms. 4. This class have showed that strong verbs had various forms in the same tenses. Now I hace proved the first hypothesis and also the second one. In short these facts have showed that the strong verbs of class Ⅳ in Charcer's English had retained very good ablaut series in Middle English.

가족력에 따른 알콜금단섬망의 임상적 고찰

박두병,정선호,민경준,이재광 중앙대학교 의과대학 의과학연구소 1995 中央醫大誌 Vol.20 No.3

It was suggested that the group of familial alcoholics ha more severe clinical pictures of alcoholim, more diagnosed as personality disorders, worse academic and social functioning, more severe physical complication and a family background of more psychopathology and lower socioeconomic status. Thus the authors intend to compare 62 patients of alcohol withdrawal delirium who had been admitted to department of psychiatry Chung Ang University Hospital (Pildong and Youngsan)from July 1st 1990 to June 30th 1995 according to their family history of alcoholism. And the familial alcoholics bagan their drinking at younger age, more frequently admitted through emergency service while shorter duration of admission. Of the clinical scales of MMPI Hy scale and Mf scale were significantly different according to family history of alcoholism.

중년과 노년기의 수면장애

박두병,민병근 중앙대부설한국의과학연구소 1988 한국의과학 Vol.20 No.2

流通 코스트를 節減하자

朴斗秉 한국마케팅연구원 1971 마케팅 Vol.5 No.4

쵸서의 영어에 나타난 어말 -e에 관한 연구

朴兜秉 한국영어영문학회 1991 영어 영문학 Vol.37 No.3

자기공명 영상을 이용한 기분장애 환자의 측두엽크기 측정

조인희,나철,이재우,박두병 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.5

목 적 : 본 연구는 기분장애 환자에서 측두엽의 신경해부학적 이상을 관찰하고자 수행되었다. 방 법 : 중앙대학교 부속 용산병원과 필동병원 신경정신과 입원 환자 중에서 DSM-Ⅲ-R에 의거하여 진단된 조증 환자 13명, 정신병적 삽화가 있는 우울증 환자 14명, 정신병적 삽화가 없는 우울증 환자 23명으로 구성된 기분장애 환자 50명과 성별과 연령에서 유의한 차이가 없었던 정상대조군 50명을 대상으로 측두엽이 포함된 뇌자기 공명 영상 6∼8개의 단면을 이용하여 측두엽의 면적과 용적을 측정 비교하였다. 결 과 : 대조군과 비교하여 환자군에서의 소견은 다음과 같다. 1) 전체 측두엽 및 우측 측두엽의 용적에서 환자군과 대조군사이에 유의한 차이가 없었다. 2) 기분장애 환자의 좌측 측두엽의 용적이 대조군보다 유의하게 적었다(p<0.05). 3) 기분 장애 환자를 조증과 우울증으로 나눈 뒤 대조군과 비교한 결과 우울증에서만 좌측 측두엽 용적에서 유의한 차이를 보였다(p<0.05). 4) 우울증을 다시 정신병적 삽화의 유무에 따라 두 군으로 나눈 후 대조군과 비교한 결과 정신병적 삽화를 동반한 우울증의 경우에서만 대조군에 비해 좌측 측두엽의 용적이 유의하게 적었다(p<0.05). 결 론 : 기분장애는 측두엽 용적에서 대조군과 큰 차이가 없었으나 본 연구에서 나타난 좌측 측두엽 용적의 감소는 정신병적 삽화를 동반한 우울증 환자군에 의해서 나타난 것으로 이 환자군은 기분장애의 다른 진단 아형들과 구분되어 정신분열증과 기분장애의 사이에 위치한 스펙트럼을 갖는 질환으로 구분될 수 있다는 이전의 가설들을 지지해 주며 기존의 기분장애와 좀 더 다른 진단적 구분을 고려해야 할 것이다. Objects : This study was performed to investigate neuroanatomical change in the temporal lobe in the patients with mood disorder. Methods : The study groups were consisted of 13 patients with major depressive disorder with psychotic feature, 23 patients with major depressive disorder without psychotic feature, 13 patients with bipolar disorder and 50 age-matched control group. We used DSM-Ⅲ-R criteria for classifying our patients. We estimated the area and volume of the left, right and total temporal lobe in selected 6-8 coronal MR images including the boundary of the temporal lobe. We compared the results of both patients with mood disorder and control group. Results : There was no significant difference in the volume of total and right temporal lobe between the patients with mood disorder and control group. But the average volume of the left temporal lobe was significantly smaller than that of the control group. After patients were divided according to subtype, the patient group was compared with control group. The average volume of the left temporal lobe in the patients with depressive disorder was smaller than that of control group, however there were no significant difference in between the patients with bipolar and control group. Among the subtype of depressive diseases, the patients with psychotic feature was significantly smaller than control subjects in the volume of left temporal lobe. Conclusion : Finally, we could find that there was significantly smaller volume in left temporal lobe only in the patients with major depressive disorder with psychotic feature. This findings support the previous hypothesis that in contrast to other subtype of mood disorder, major depressive disorder with psychotic feature should be classified to be the spectrum disease lying between schizophrenia and mood disorder.

소아의 수면 발달과 이상수면

박두병 大韓神經精神醫學會 1989 신경정신의학 Vol.28 No.5

In newborns, sleep and wakefulness are distributed evenly across the 24-hour day ; periods of sleep, 3 to 4 hours in length, are followed by 1-to 2-hour intervals of wakefulness. Gradually, these short episodes of sleep become consolidated into longer periods and shift to the nighttime hours, while the intervening episodes of wakefulness become briefer. The infant's ability to sustain long intervals of uninterrupted sleep dramatically increases from slightly less than 4 hours at 2 weeks of age to more than 7 hours by 5months of age. By the end of the first year, the child wakefulness is concentrated in the daytime and sleep at night; a diurnal pattern is well developed by 3 to 4 months of age. Parasomina(or dyssomnia) refers to a group of acute, episodic, physical phenomena generally seen during, or exacerbated by, nocturnal sleep. Under this classification are included somnambulism(sleep walking), night terrors, bruxism, nightmare and enuresis. Somnambulism, night terrors and perhaps enuresis are SWS disorders, while nightmares are REM sleep phenomena and bruxism occurs independent of sleep stage.